Item Type | Name |
Academic Article
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Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein.
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Academic Article
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Moesin, and not the murine functional homologue (Crry/p65) of human membrane cofactor protein (CD46), is involved in the entry of measles virus (strain Edmonston) into susceptible murine cell lines.
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Academic Article
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Mouse Crry/p65. Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAF.
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Academic Article
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Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induced apoptosis.
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Academic Article
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Induction of peri-insulitis but not diabetes in islet transplants expressing a single foreign antigen. A multi-stage model of disease.
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Academic Article
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Resting B cells from New Zealand Black mice demonstrate a defect in apoptosis induction following surface IgM ligation.
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Academic Article
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The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function.
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Academic Article
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Characterization of C3 receptors on cultured rat glomerular endothelial cells.
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Academic Article
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Characterization of C3-binding proteins on mouse neutrophils and platelets.
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Academic Article
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Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells.
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Academic Article
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EBV binds to lymphocytes of transgenic mice that express the human CR2 gene.
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Academic Article
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Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor.
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Academic Article
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Macrophage-colony-stimulating factor regulates expression of the integrins alpha 4 beta 1 and alpha 5 beta 1 by murine bone marrow macrophages.
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Academic Article
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Characterization of rat complement receptors and regulatory proteins. CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1.
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Academic Article
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Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules.
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Academic Article
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Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.
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Academic Article
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Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury.
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Academic Article
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Expression of the murine complement regulatory protein crry by glial cells and neurons.
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Academic Article
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Phenotypes of complement knockouts.
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Academic Article
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Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure.
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Academic Article
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Inhibiting the complement system does not reduce injury in renal ischemia reperfusion.
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Academic Article
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Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein.
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Academic Article
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Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice.
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Academic Article
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The serum resistance of malaria-infected erythrocytes.
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Academic Article
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Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice.
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Academic Article
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Arthritis critically dependent on innate immune system players.
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Academic Article
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Analysis of Epstein-Barr virus-binding sites on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides. At least two distinct sites are necessary for ligand-receptor interaction.
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Academic Article
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Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice.
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Academic Article
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Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice.
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Academic Article
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Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury.
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Academic Article
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Inhibition of complement activation decreases airway inflammation and hyperresponsiveness.
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Academic Article
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Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.
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Academic Article
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Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis.
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Academic Article
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Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
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Academic Article
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A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice.
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Academic Article
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Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects.
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Academic Article
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Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.
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Academic Article
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Complement receptors and the shaping of the natural antibody repertoire.
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Academic Article
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B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens.
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Academic Article
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Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.
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Academic Article
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Innate autoimmunity.
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Academic Article
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Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.
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Academic Article
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Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.
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Academic Article
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Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
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Academic Article
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Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.
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Academic Article
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Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury.
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Academic Article
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Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis.
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Academic Article
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Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice.
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Academic Article
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The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita.
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Academic Article
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Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissues.
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Academic Article
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Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway.
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Academic Article
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Complement is an essential component of the immune response to adeno-associated virus vectors.
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Academic Article
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Antibodies to citrullinated proteins: pathogenic and diagnostic significance.
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Academic Article
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Evidence for non-traditional activation of complement factor C3 during murine liver regeneration.
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Academic Article
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Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens.
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Academic Article
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The spectrum of complement alternative pathway-mediated diseases.
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Academic Article
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Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies.
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Academic Article
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A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury.
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Academic Article
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Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice.
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Academic Article
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Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.
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Academic Article
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Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice.
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Academic Article
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Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion.
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Academic Article
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The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.
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Academic Article
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Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B.
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Academic Article
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N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
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Academic Article
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Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.
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Academic Article
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Mice expressing human CR1/CD35 have an enhanced humoral immune response to T-dependent antigens but fail to correct the effect of premature human CR2 expression.
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Academic Article
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Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli.
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Academic Article
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Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.
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Academic Article
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CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants.
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Academic Article
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Identification of a central role for complement in osteoarthritis.
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Academic Article
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Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.
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Academic Article
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Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice.
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Academic Article
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Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice.
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Academic Article
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Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.
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Academic Article
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Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1.
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Academic Article
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A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis.
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Academic Article
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IgM contributes to glomerular injury in FSGS.
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Academic Article
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Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.
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Academic Article
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Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y.
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Academic Article
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Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation.
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Academic Article
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Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2.
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Academic Article
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Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo.
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Academic Article
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Mouse Crry/p65 is a regulator of the alternative pathway of complement activation.
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Academic Article
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Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.
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Academic Article
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Anti-C1q autoantibodies amplify pathogenic complement activation in systemic lupus erythematosus.
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Academic Article
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Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway.
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Academic Article
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Complement component c5a is integral to the febrile response of mice to lipopolysaccharide.
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Academic Article
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An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2, CD21) gene.
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Academic Article
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Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response.
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Academic Article
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Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
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Academic Article
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A prototype pathogen bound ex vivo to human erythrocyte complement receptor 1 via bispecific monoclonal antibody complexes is cleared to the liver in a mouse model.
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Academic Article
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A critical role for murine complement regulator crry in fetomaternal tolerance.
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Academic Article
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Complement receptors.
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Academic Article
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Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function.
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Academic Article
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Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure.
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Academic Article
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Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation.
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Academic Article
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Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction.
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Academic Article
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A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation.
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Academic Article
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Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice.
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Academic Article
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A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.
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Academic Article
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Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.
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Academic Article
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Structural requirements for C3d,g/Epstein-Barr virus receptor (CR2/CD21) ligand binding, internalization, and viral infection.
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Academic Article
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Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire.
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Academic Article
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The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
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Academic Article
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Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.
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Academic Article
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Effects of complement factor D deficiency on the renal disease of MRL/lpr mice.
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Academic Article
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CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE.
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Academic Article
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Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3.
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Academic Article
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The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy.
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Academic Article
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Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.
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Academic Article
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A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.
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Academic Article
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Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling.
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Academic Article
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C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion.
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Academic Article
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Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development.
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Academic Article
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Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice.
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Academic Article
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Cutting edge: Complement (C3d)-linked antigens break B cell anergy.
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Academic Article
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Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells.
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Academic Article
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Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).
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Academic Article
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Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury.
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Academic Article
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Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists.
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Academic Article
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Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
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Academic Article
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Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II.
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Academic Article
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A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.
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Academic Article
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B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion.
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Academic Article
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Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.
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Academic Article
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The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization.
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Academic Article
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The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.
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Academic Article
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A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice.
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Academic Article
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Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization.
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Academic Article
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Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.
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Academic Article
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Human peripheral blood monocytes display surface antigens recognized by monoclonal antinuclear antibodies.
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Academic Article
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Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice.
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Academic Article
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Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.
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Academic Article
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Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis.
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Academic Article
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Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE).
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Academic Article
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Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE.
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Academic Article
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Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.
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Academic Article
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Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.
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Academic Article
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Detection of complement activation using monoclonal antibodies against C3d.
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Concept
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Mice, Inbred CBA
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred AKR
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Concept
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Mice, Inbred MRL lpr
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Concept
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Mice, Knockout
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Concept
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Mice, Inbred C3H
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Concept
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Mice, Inbred Strains
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Concept
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Mice, Inbred NZB
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Concept
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Mice
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Concept
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Mice, Inbred DBA
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Concept
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Mice, Mutant Strains
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Transgenic
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Academic Article
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Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury.
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Academic Article
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Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression.
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Academic Article
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A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease.
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Academic Article
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Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.
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Academic Article
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A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA.
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Academic Article
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IgM exacerbates glomerular disease progression in complement-induced glomerulopathy.
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Academic Article
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Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.
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Academic Article
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Annexin A2 Enhances Complement Activation by Inhibiting Factor H.
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Academic Article
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Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.
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Academic Article
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Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
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Academic Article
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Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing.
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Academic Article
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Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
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Grant
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Mouse Membrane RCA Proteins in the Immune Response
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Grant
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Disconnecting CR2/CD21 from Its C3d Ligand to Ameliorate Lupus
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Grant
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Denver Autoimmunity Center of Excellence
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Academic Article
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Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.
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Academic Article
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Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.
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Academic Article
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A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.
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Academic Article
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Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.
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Academic Article
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Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.
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Academic Article
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The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.
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Academic Article
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Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.
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Academic Article
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Complement in the Initiation and Evolution of Rheumatoid Arthritis.
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Academic Article
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Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis.
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Academic Article
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Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.
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Academic Article
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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis.
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Academic Article
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
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Academic Article
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Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus.
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Academic Article
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Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D.
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Academic Article
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Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF.
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Academic Article
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C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice.
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Academic Article
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A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury.
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Academic Article
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Complement component factor B has thrombin-like activity.
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Academic Article
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A Potential New Mouse Model of Axial Spondyloarthritis Involving the Complement System.
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Academic Article
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Marginal zone B cells acquire dendritic cell functions by trogocytosis.
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Academic Article
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Factor H related proteins modulate complement activation on kidney cells.
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Academic Article
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Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum.
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Academic Article
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Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop.
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Academic Article
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Noninvasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent Imaging Probe.
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Academic Article
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Complement therapeutics are coming of age in rheumatology.
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Academic Article
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Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury.
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Academic Article
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Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins.
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