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Search Results to Mario L Santiago

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Santiago, Mario

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Our laboratory studies the interplay between the innate and adaptive immune response against retroviruses to conceptually advance vaccine and cure strategies against HIV/AIDS. We are specifically interested in “restriction factors” – host proteins that could directly inhibit retroviruses but we discovered also play critical roles in shaping adaptive immune responses. These factors could be regulated by Type I interferons, thus highlighting possibilities for clinical translation.

One or more keywords matched the following items that are connected to Santiago, Mario

Item Type	Name
Academic Article	Noninvasive detection of Simian immunodeficiency virus infection in a wild-living L'Hoest's monkey (Cercopithecus Ihoesti).
Academic Article	Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees.
Academic Article	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.
Academic Article	Humoral immunity in the Friend retrovirus infection model.
Academic Article	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.
Academic Article	Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee.
Academic Article	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
Academic Article	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.
Academic Article	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.
Academic Article	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.
Academic Article	A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.
Academic Article	IFN-a treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.
Concept	Retroviridae Infections
Concept	Endogenous Retroviruses
Concept	Retroviridae
Concept	Retroviridae Proteins
Academic Article	Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
Academic Article	Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.
Academic Article	Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.
Academic Article	Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.
Academic Article	The role of the APOBEC3 family of cytidine deaminases in innate immunity, G to A hypermutation, and evolution of retroviruses. In: The Origin and Evolution of Viruses, E. Domingo, C. Parish, J.L. Holland (eds.)
Academic Article	Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.
Academic Article	Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer.
Academic Article	Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Academic Article	Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.
Grant	Apobec3 and the Neutralizing Antibody Response Against Pathogenic Retroviruses
Grant	Innate Restriction Factor Modulation of Retrovirus-specific Humoral Immunity
Grant	APOBEC3/Rfv3 and Immunoglobulin Somatic Hypermutation
Grant	HIV-Associated Interferon Effector Mechanisms in the GALT
Grant	Immunological impact of Tetherin retrovirus restriction
Academic Article	A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.
Academic Article	Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.
Academic Article	Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease.
Academic Article	SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.

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Retroviridae