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Search Results to Mario L Santiago

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Santiago, Mario

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Our laboratory studies the interplay between the innate and adaptive immune response against retroviruses to conceptually advance vaccine and cure strategies against HIV/AIDS. We are specifically interested in “restriction factors” – host proteins that could directly inhibit retroviruses but we discovered also play critical roles in shaping adaptive immune responses. These factors could be regulated by Type I interferons, thus highlighting possibilities for clinical translation.

One or more keywords matched the following items that are connected to Santiago, Mario

Item Type	Name
Academic Article	IFN-a treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.
Concept	Interferon-beta
Concept	Interferon-gamma
Concept	Receptor, Interferon alpha-beta
Concept	Interferon-alpha
Concept	Interferons
Concept	Interferon Regulatory Factor-7
Concept	Interferon Type I
Academic Article	Interferon-a Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.
Academic Article	Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.
Academic Article	T Cell Production of IFN? in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses.
Academic Article	Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.
Grant	Apobec3 and the Neutralizing Antibody Response Against Pathogenic Retroviruses
Grant	Innate Restriction Factor Modulation of Retrovirus-specific Humoral Immunity
Grant	HIV-Associated Interferon Effector Mechanisms in the GALT
Grant	Role of Type I IFNs in Mucosal HIV-1 Immunity and Pathogenesis
Academic Article	SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways.
Academic Article	A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis.
Academic Article	A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.
Concept	Interferon-Induced Helicase, IFIH1
Academic Article	Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFN? Production From Human Colonic ILC3s via Multiple Mechanisms.
Academic Article	Different Biological Activities of Specific Interferon Alpha Subtypes.
Academic Article	Diverse Immunomodulatory Effects of Individual IFNa Subtypes on Virus-Specific CD8+ T Cell Responses.
Academic Article	HIV infection does not alter interferon a/? receptor 2 expression on mucosal immune cells.
Academic Article	Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease.
Academic Article	Qualitative Differences Between the IFNa subtypes and IFN? Influence Chronic Mucosal HIV-1 Pathogenesis.
Academic Article	Interferon Resistance of Emerging SARS-CoV-2 Variants.
Academic Article	Specialized interferon action in COVID-19.
Academic Article	Interferon resistance of emerging SARS-CoV-2 variants.
Academic Article	SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.
Academic Article	Regulation of human interferon signaling by transposon exonization.

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Interferons