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Search Results to Mario L Santiago

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Santiago, Mario

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Our laboratory studies the interplay between the innate and adaptive immune response against retroviruses to conceptually advance vaccine and cure strategies against HIV/AIDS. We are specifically interested in “restriction factors” – host proteins that could directly inhibit retroviruses but we discovered also play critical roles in shaping adaptive immune responses. These factors could be regulated by Type I interferons, thus highlighting possibilities for clinical translation.

One or more keywords matched the following items that are connected to Santiago, Mario

Item Type	Name
Academic Article	The origins of acquired immune deficiency syndrome viruses: where and when?
Academic Article	Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Ta? Forest, C?te d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2.
Academic Article	Chimpanzee reservoirs of pandemic and nonpandemic HIV-1.
Academic Article	Effective activation alleviates the replication block of CCR5-tropic HIV-1 in chimpanzee CD4+ lymphocytes.
Academic Article	Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.
Academic Article	Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.
Academic Article	Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution.
Academic Article	Distinct evolutionary pressures underlie diversity in simian immunodeficiency virus and human immunodeficiency virus lineages.
Academic Article	Origin of AIDS: contaminated polio vaccine theory refuted.
Academic Article	Molecular epidemiology of HIV-1 infection in the Philippines, 1985 to 1997: transmission of subtypes B and E and potential emergence of subtypes C and F.
Academic Article	SIVcpz in wild chimpanzees.
Academic Article	Amplification of a complete simian immunodeficiency virus genome from fecal RNA of a wild chimpanzee.
Academic Article	Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.
Academic Article	Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Academic Article	Lentivirus restriction by diverse primate APOBEC3A proteins.
Concept	HIV Seropositivity
Concept	HIV-1
Concept	HIV Antibodies
Concept	HIV-2
Concept	HIV Reverse Transcriptase
Concept	HIV Envelope Protein gp120
Concept	HIV
Concept	HIV Core Protein p24
Concept	HIV Infections
Academic Article	Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo.
Academic Article	Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains.
Academic Article	Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain.
Academic Article	Interferon-a Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.
Academic Article	Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection.
Academic Article	Tetherin/BST-2: Restriction Factor or Immunomodulator?
Academic Article	Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.
Academic Article	A chimeric human APOBEC3A protein with a three amino acid insertion confers differential HIV-1 and adeno-associated virus restriction.
Academic Article	Encyclopedia of AIDS (eds. Hope TJ, Stevenson M, Richman D)
Academic Article	Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation.
Academic Article	The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria.
Grant	Apobec3 and the Neutralizing Antibody Response Against Pathogenic Retroviruses
Grant	Innate Restriction Factor Modulation of Retrovirus-specific Humoral Immunity
Grant	APOBEC3/Rfv3 and Immunoglobulin Somatic Hypermutation
Grant	HIV-Associated Interferon Effector Mechanisms in the GALT
Grant	Immunological impact of Tetherin retrovirus restriction
Academic Article	Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1.
Academic Article	Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies.
Grant	Role of Type I IFNs in Mucosal HIV-1 Immunity and Pathogenesis
Academic Article	SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways.
Academic Article	A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis.
Academic Article	Different Biological Activities of Specific Interferon Alpha Subtypes.
Academic Article	HIV infection does not alter interferon a/? receptor 2 expression on mucosal immune cells.
Grant	Gut Cytotoxic CD4 T cells in HIV-1 Pathogenesis
Academic Article	Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1.
Academic Article	Qualitative Differences Between the IFNa subtypes and IFN? Influence Chronic Mucosal HIV-1 Pathogenesis.
Academic Article	Quantifying HIV-1-Mediated Gut CD4+ T Cell Deathin the Lamina Propria Aggregate Culture (LPAC) Model.
Academic Article	Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection.
Academic Article	Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection.
Academic Article	SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.
Academic Article	Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles.

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