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Proenza, Catherine

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The central goal of my research program is to understand the molecular basis of pacemaking in the sinoatrial node of the heart. Projects irange from ion channel biophysics to whole animal physiology. Information about the molecular mechanisms that govern cardiac pacemaking is critical for the development of novel and specific therapies to control heart rate. My group has extensive experience in patch clamp recordings from isolated sinoatrial node myocytes, transfected cell lines and iPSC-derived cardiomyocytes. We have also pioneered other methods for study of the sinoatrial node, including ECG recordings from unanesthetized mice, biochemistry using mouse sinoatrial node samples, immunocytochemistry, and computational approaches.

One or more keywords matched the following items that are connected to Proenza, Catherine

Item Type	Name
Concept	Myocytes, Cardiac
Concept	Muscle Cells
Academic Article	Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate.
Academic Article	PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.
Academic Article	Culture and adenoviral infection of sinoatrial node myocytes from adult mice.
Academic Article	High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Academic Article	Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes.
Academic Article	Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes.
Grant	Regulation of excitability in sinoatrial myocytes
Academic Article	Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice.
Academic Article	Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes.
Academic Article	Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.
Academic Article	ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials.

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Muscle Cells