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Wesolowski, Stephanie

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My long-term goal is to understand how altered nutrient supply programs fetal metabolism and how these changes may persist after birth and increase susceptibility to adult metabolic disease. My primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. This is important in understanding why IUGR offspring have increased susceptibility to diabetes across their lifespan. I am also involved in projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of non-alcoholic fatty liver disease (NAFLD) and immune cell reprogramming. Current Projects in the lab with cellular metabolism, molecular biology, metabolic flux, and in vivo fetal physiology include: • Molecular mechanisms for early development of fetal hepatic insulin resistance on suppression of glucose production in fetuses with IUGR • Coordination of carbon and energy substrates (metabolic flux) within the liver and from other fetal organs and the placenta to support early activation of hepatic glucose production in IUGR fetus • Role of hypoxia versus hypoglycemia in the early activation of fetal hepatic glucose production • Effect of intrauterine exposures on fetal hepatic immune cell programming and function • Mechanisms for early development of steatosis and NAFLD risk following exposure to maternal obesity • Intrauterine intervention strategies to prevent later life metabolic disease risk

One or more keywords matched the following items that are connected to Wesolowski, Stephanie

Item Type	Name
Academic Article	Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.
Academic Article	A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.
Concept	Placental Insufficiency
Academic Article	Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.
Academic Article	Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production.
Academic Article	Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep.
Grant	Effect of hypoxia on glucose metabolism in IUGR fetal liver
Academic Article	Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.
Academic Article	Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates.
Academic Article	Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb.
Academic Article	Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep.
Academic Article	Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth.
Academic Article	Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses.
Academic Article	Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency.
Academic Article	Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep.
Academic Article	Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.

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Placental Insufficiency