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Wesolowski, Stephanie

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My long-term goal is to understand how altered nutrient supply programs fetal metabolism and how these changes may persist after birth and increase susceptibility to adult metabolic disease. My primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. This is important in understanding why IUGR offspring have increased susceptibility to diabetes across their lifespan. I am also involved in projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of non-alcoholic fatty liver disease (NAFLD) and immune cell reprogramming. Current Projects in the lab with cellular metabolism, molecular biology, metabolic flux, and in vivo fetal physiology include: • Molecular mechanisms for early development of fetal hepatic insulin resistance on suppression of glucose production in fetuses with IUGR • Coordination of carbon and energy substrates (metabolic flux) within the liver and from other fetal organs and the placenta to support early activation of hepatic glucose production in IUGR fetus • Role of hypoxia versus hypoglycemia in the early activation of fetal hepatic glucose production • Effect of intrauterine exposures on fetal hepatic immune cell programming and function • Mechanisms for early development of steatosis and NAFLD risk following exposure to maternal obesity • Intrauterine intervention strategies to prevent later life metabolic disease risk

One or more keywords matched the following items that are connected to Wesolowski, Stephanie

Item Type	Name
Academic Article	Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Academic Article	Insulin regulates hepatic leptin receptor expression in early lactating dairy cows.
Academic Article	Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.
Academic Article	A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.
Academic Article	Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques.
Academic Article	Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ?-cell mass in fetal sheep.
Academic Article	Prolonged infusion of amino acids increases leucine oxidation in fetal sheep.
Academic Article	Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin.
Academic Article	Increased fetal insulin concentrations for one week fail to improve insulin secretion or ?-cell mass in fetal sheep with chronically reduced glucose supply.
Concept	Glucose Tolerance Test
Concept	Glucose Clamp Technique
Concept	Blood Glucose
Concept	Glucose-6-Phosphatase
Concept	Glucose Intolerance
Concept	Glucose Transporter Type 2
Concept	Glucose
Academic Article	Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates.
Academic Article	Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus.
Academic Article	Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.
Academic Article	Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.
Academic Article	Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows.
Academic Article	Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.
Academic Article	Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.
Academic Article	Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production.
Academic Article	Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.
Grant	TISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUS
Grant	Effect of hypoxia on glucose metabolism in IUGR fetal liver
Grant	Mechanisms for Fetal Hepatic Programming during Intrauterine Growth Restriction
Grant	Nutrient and Insulin Metabolic Actions in IUGR Fetal Liver
Academic Article	Pulsatile hyperglycemia increases insulin secretion but not pancreatic ?-cell mass in intrauterine growth-restricted fetal sheep.
Academic Article	Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring.
Academic Article	Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.
Grant	Glucose metabolism in the fetal liver during hypoxia
Academic Article	Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.
Academic Article	Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates.
Academic Article	A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ? Cells in Late-Gestation Sheep.
Academic Article	Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.
Academic Article	Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep.
Academic Article	Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
Academic Article	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model.
Academic Article	Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.
Academic Article	Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
Academic Article	Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.

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