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Wesolowski, Stephanie

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My long-term goal is to understand how altered nutrient supply programs fetal metabolism and how these changes may persist after birth and increase susceptibility to adult metabolic disease. My primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. This is important in understanding why IUGR offspring have increased susceptibility to diabetes across their lifespan. I am also involved in projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of non-alcoholic fatty liver disease (NAFLD) and immune cell reprogramming. Current Projects in the lab with cellular metabolism, molecular biology, metabolic flux, and in vivo fetal physiology include: • Molecular mechanisms for early development of fetal hepatic insulin resistance on suppression of glucose production in fetuses with IUGR • Coordination of carbon and energy substrates (metabolic flux) within the liver and from other fetal organs and the placenta to support early activation of hepatic glucose production in IUGR fetus • Role of hypoxia versus hypoglycemia in the early activation of fetal hepatic glucose production • Effect of intrauterine exposures on fetal hepatic immune cell programming and function • Mechanisms for early development of steatosis and NAFLD risk following exposure to maternal obesity • Intrauterine intervention strategies to prevent later life metabolic disease risk

One or more keywords matched the following items that are connected to Wesolowski, Stephanie

Item Type	Name
Academic Article	Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin.
Concept	Oxygen Consumption
Academic Article	Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.
Academic Article	Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production.
Academic Article	Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.
Grant	Interrupting the Vicious Cycle of Obesity and Metabolic Syndrome
Grant	TISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUS
Grant	Effect of hypoxia on glucose metabolism in IUGR fetal liver
Grant	Mechanisms for Fetal Hepatic Programming during Intrauterine Growth Restriction
Grant	Nutrient and Insulin Metabolic Actions in IUGR Fetal Liver
Academic Article	Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.
Academic Article	Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb.
Academic Article	Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.
Academic Article	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model.
Grant	Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non Human Primates
Academic Article	Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.

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