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Search Results to Lori Walker

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One or more keywords matched the following properties of Walker, Lori

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overview My work is focused on two distinct aspects of cardiac function. The first project focuses on the dedifferentiation of adult cardiac myocytes. We have recently identified a novel protein that induces adult myocytes to dedifferentiate to a neonatal, proliferative phenotype. Elucidating the signaling pathways involved and identifying inhibitors of this process promise to significantly advance our understanding of the pathogenesis of cardiac dysfunction. The second project in my laboratory is aimed at elucidating the effects of cannabis on cardiac health. We have recently shown that cannabis users are protected from death following MI. However, a prospective project examining the effects of cannabis consumption on cardiac rate and rhythm suggests that people with pre-existing cardiac disease may have an increased risk of arrhythmias following cannabis use. We have an ongoing clinical study as well as basic science efforts into the mechanisms of cannabis induced changes in vascular and cardiac contractility. I will be serving as a cardiology mentor for the 2018-2019 academic year.

One or more keywords matched the following items that are connected to Walker, Lori

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Academic Article Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support.
Academic Article Depressed cardiac myofilament function in human diabetes mellitus.
Academic Article Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils.
Concept Myocytes, Smooth Muscle
Concept Myocytes, Cardiac
Academic Article Enhanced myofilament responsiveness upon ?-adrenergic stimulation in post-infarct remodeled myocardium.
Academic Article Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.
Academic Article Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium.
Academic Article Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure.
Academic Article The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function.
Academic Article Receptor-activated increases in intracellular calcium and protein tyrosine phosphorylation in vascular smooth muscle cells.
Academic Article Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells.
Academic Article Differential Tissue-Specific Function of Adora2b in Cardioprotection.
Academic Article High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Academic Article Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model.
Academic Article The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation.
Academic Article Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy.

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