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Search Results to Peter M. Henson

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One or more keywords matched the following properties of Henson, Peter

overview I have a longstanding interest in myeloid cells, mononuclear phagocytes and inflammation. Over more than 50 years these interests have, and do, include mechanisms of induction of the inflammatory process and in particular of its regulation and resolution, as well as defects in this that are associated with longer-term sequelae such as tissue remodeling, fibrosis, persistent injury and enhanced or deranged immunological responses. An emphasis on mononuclear phagocyte (monocyte, macrophage and dendritic cell) participation in these processes demonstrated roles and mechanisms for recognition and removal of apoptotic cells and tissue debris after injury and inflammation. Cell removal also occurs in normal cell turnover and maintenance of tissue homeostasis - by mechanisms we termed "efferocytosis" and showed to involve recognition of phosphatidylserine (PS) exposed on apoptotic cells as a result loss of membrane phospholipid asymmetry. In general these cell removal processes were shown to be accompanied by inflammosuppressive mediators that minimize tissue responses and lead to resolution of inflammation as well as active contribution to tissue remodeling and ideally, return to normal structure and function. Equally important were related studies of monocyte/macrophage programing towards a variety of reparative, tissue-modifying and immunomodulatory functions. These in turn were shown to be major players resolution of inflammation and return of tissues to normal structure and function, but also can contribute to abnormal repair as in fibrosis. Thus our studies have consistently addressed mechanisms and signal pathways involved in vivo during inflammation and fibroproliferative responses especially in the respiratory tract. Our research and translational interests in this regard have included ARDS, COPD, Asthma, airways inflammation and interstitial lung diseases (ILD), especially IPF.

One or more keywords matched the following items that are connected to Henson, Peter

Item TypeName
Academic Article Neutrophil and platelet interactions in "allergic" and inflammatory reactions: a role for acetyl glyceryl ether phosphorylcholine (platelet-activating factor).
Academic Article Modulation of macrophage maturation by cytokines and lipid mediators: a potential role in resolution of pulmonary inflammation.
Academic Article Role of alveolar macrophages in endotoxin-induced neutrophilic alveolitis in rats.
Academic Article Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets.
Academic Article The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.
Academic Article Accumulation of platelets at sites of antigen-antibody-mediated injury: a possible role for IgE antibody and mast cells.
Academic Article Studies on the role of tumor necrosis factor in adult respiratory distress syndrome.
Academic Article The role of phosphatidylserine in recognition of apoptotic cells by phagocytes.
Academic Article Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms.
Academic Article Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor.
Academic Article Role of endogenously derived leukotrienes in the regulation of lysosomal enzyme expression in macrophages exposed to beta 1,3-glucan.
Academic Article Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis.
Academic Article Control of local blood flow in pulmonary inflammation: role for neutrophils, PAF, and thromboxane.
Academic Article Phagocytic clearance of apoptotic cells: role in lung disease.
Academic Article Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation.
Academic Article Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia.
Academic Article Role of prostaglandin synthesis in rabbit platelet activation induced by basophil-derived platelet-activating factor.
Academic Article Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement.
Academic Article Disparate role of the beta 2-integrin CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit.
Academic Article Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis.
Academic Article NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities.
Academic Article Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPK mitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis.
Academic Article Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil beta2 (DC18) integrins.
Academic Article A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.
Academic Article Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases.
Academic Article Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis.
Academic Article Retention of leukocytes in capillaries: role of cell size and deformability.
Academic Article Phospholipase A2 contamination of cobra venom factor preparations. Biologic role in complement-dependent in vivo reactions and inactivation with p-bromophenacyl bromide.
Academic Article Differential regulation of gene expression during macrophage activation with a polyribonucleotide. The role of endogenously derived IFN.
Academic Article Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
Academic Article Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts.
Grant Regulation of inflammation by pulmonary collectins
Grant Uptake of apoptotic cells
Grant Ether Lipids, Elcosanoids, and Lung Cell Pathophysiology
Grant Collectin-induced phagocytosis of apoptotic cells
Grant Regulation of Pulmonary Inflammation
Grant Neutrophil Nox2 controls mononuclear cell functions in inflammation; role in CGD
Grant Roles for interstitial and airspace macrophages in resolution of pulmonary inflammation

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