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Search Results to Dennis R Roop

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Roop, Dennis

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Item Type	Name
Academic Article	Proto-oncogene expression during two-stage carcinogenesis in mouse skin.
Academic Article	Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments.
Academic Article	Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.
Academic Article	Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.
Academic Article	Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.
Academic Article	Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.
Academic Article	Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion.
Academic Article	Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors.
Academic Article	Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development.
Academic Article	Multiple defects and perinatal death in mice deficient in follistatin.
Academic Article	Epidermis: an attractive target tissue for gene therapy.
Academic Article	Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.
Academic Article	Loricrin immunoreactivity in human skin: localization to specific granules (L-granules) in acrosyringia.
Academic Article	Multistage skin carcinogenesis in transgenic mice.
Academic Article	Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14.
Academic Article	The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.
Academic Article	A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis.
Academic Article	Langerhans cells in the TGF beta 1 null mouse.
Academic Article	A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma.
Academic Article	Development of transgenic mouse models of skin carcinogenesis: potential applications.
Academic Article	Differentiation and tumor response to retinobenzoic acid RE-80 in a malignant conversion model.
Academic Article	Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.
Academic Article	Transgenic models of skin diseases.
Academic Article	Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Academic Article	A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens.
Academic Article	Transduction of a preselected population of human epidermal stem cells: consequences for gene therapy.
Academic Article	Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Academic Article	Full-thickness skin grafts from flaky skin mice to nude mice: maintenance of the psoriasiform phenotype.
Academic Article	Characterization of loricrin regulation in vitro and in transgenic mice.
Academic Article	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.
Academic Article	NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
Academic Article	Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders.
Academic Article	An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy.
Academic Article	Changes in photo-aged human skin following topical application of all-trans retinoic acid.
Academic Article	Immunological gene therapy approaches for malignant melanoma. 1. Tumor-immunological background.
Academic Article	Immunological gene therapy approaches for malignant melanoma. 2. Preclinical studies and clinical strategies.
Academic Article	Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors.
Academic Article	Early expression of type I K13 keratin in the progression of mouse skin papillomas.
Academic Article	Interaction between dermal papilla and bulge: the rhino mouse mutation as a model system.
Academic Article	Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.
Academic Article	Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.
Academic Article	p63 is the molecular switch for initiation of an epithelial stratification program.
Academic Article	Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function.
Academic Article	Mechanisms regulating epithelial stratification.
Academic Article	An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Academic Article	Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.
Academic Article	The malignant conversion step of mouse skin carcinogenesis.
Academic Article	Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita.
Academic Article	Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
Academic Article	Hedgehog in Wnterland.
Academic Article	Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Academic Article	Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression.
Academic Article	A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.
Academic Article	DeltaNp63 knockdown mice: A mouse model for AEC syndrome.
Academic Article	Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.
Academic Article	Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis.
Academic Article	p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation.
Academic Article	Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.
Academic Article	Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Academic Article	Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.
Academic Article	Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma.
Academic Article	Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.
Academic Article	Myoepitheliomas in inbred laboratory mice.
Academic Article	A fitness model for melanoma-initiating cells.
Academic Article	Aurora kinase-A deficiency during skin development impairs cell division and stratification.
Academic Article	Retinoic acid suppression of loricrin expression in reconstituted human skin cultured at the liquid-air interface.
Academic Article	TGF alpha and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas.
Academic Article	Altered distribution of keratinization markers in epidermolytic hyperkeratosis.
Academic Article	Relationship between the expression of differentiation-specific keratins 1 and 10 and cell proliferation in epidermal tumors.
Academic Article	Inducible mouse models for inherited skin diseases: implications for skin gene therapy.
Academic Article	Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Academic Article	Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function.
Academic Article	Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
Academic Article	Identification of sporadic mutations in the helix initiation motif of keratin 6 in two pachyonychia congenita patients: further evidence for a mutational hot spot.
Academic Article	Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.
Academic Article	Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.
Academic Article	Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.
Academic Article	Down-regulation of p63 is required for epidermal UV-B-induced apoptosis.
Academic Article	Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders.
Academic Article	Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Academic Article	Regulated cutaneous gene delivery: the skin as a bioreactor.
Academic Article	An unexpected role for keratin 10 end domains in susceptibility to skin cancer.
Academic Article	Conflicting roles for p63 in skin development and carcinogenesis.
Academic Article	Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease.
Academic Article	Asymmetric cell division in skin development: a new look at an old observation.
Academic Article	p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.
Academic Article	Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.
Academic Article	Treasure or artifact: a decade of p63 research speaks for itself.
Academic Article	Aberrant differentiation in mouse skin carcinogenesis.
Academic Article	Genetically engineered mouse models for skin research: taking the next step.
Academic Article	Sorting out the p63 signaling network.
Academic Article	An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue.
Academic Article	Abnormal expression and processing of keratins in pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice.
Academic Article	Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies.
Academic Article	Keratin expression in mouse epidermal tumors.
Academic Article	Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones.
Academic Article	The effect of c-myc on stem cell fate influences skin tumor phenotype.
Academic Article	Are stem cell niches shared for skin cancers?
Academic Article	Altering cell fate: from thymus epithelium to skin stem cells.
Academic Article	Nrf2 links epidermal barrier function with antioxidant defense.
Academic Article	Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance.
Academic Article	ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.
Academic Article	Aberrant expression during two-stage mouse skin carcinogenesis of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia.
Academic Article	Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.
Academic Article	Cultivation of murine hair follicles as organoids in a collagen matrix.
Concept	Skin Physiological Phenomena
Concept	Skin Diseases
Concept	Skin Pigmentation
Concept	Skin Diseases, Genetic
Concept	Skin Aging
Concept	Skin Diseases, Vesiculobullous
Concept	Skin Abnormalities
Concept	Skin Neoplasms
Concept	Skin
Concept	Skin Transplantation
Academic Article	Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.
Academic Article	Isolation and characterization of squamous cell carcinoma-derived stem-like cells: role in tumor formation.
Academic Article	Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice.
Academic Article	Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.
Academic Article	MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.
Academic Article	Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
Academic Article	Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
Academic Article	Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection.
Grant	REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
Grant	The consequences of loricrin deficiency on epidermal barrier function
Grant	INDUCIBLE MOUSE MODELS FOR SKIN AND HEAD AND NECK CANCER
Grant	TESTING GENE THERAPY FOR EPIDERMOLYSIS BULLOSA SIMPLEX
Grant	Regulation and Function of Keratins in the Epidermis
Grant	Targeting Oncogene Expression to Skin in Transgenic Mice
Grant	Molecular Mechanisms of Skin and Appendage Development
Grant	EPITHELIAL DIFFERENTIATION/KERATINIZATION GORDON CONFER
Grant	2015 Barrier Function of Mammalian Skin Gordon Research Conference
Grant	Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
Grant	Training in Translational Research of Skin Diseases
Grant	REGULATION AND FUNCTION OF A MAJOR CELL ENVELOPE PROTEIN
Grant	The Denver Network of the NHLBI Progenitor Cell Biology Consortium
Academic Article	INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma.
Academic Article	Repigmentation of Human Vitiligo Skin by NBUVB Is Controlled by Transcription of GLI1 and Activation of the ?-Catenin Pathway in the Hair Follicle Bulge Stem Cells.
Academic Article	Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte?Lipid Envelope.
Grant	Exploring Alternative iPS Cell Therapies for Recessive Dystrophic Epidermolysis Bullosa
Academic Article	Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging.
Academic Article	NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy.
Academic Article	Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling.
Academic Article	"Structural imprinting" of the cutaneous immune effector function.
Grant	Study of the Safety, Tolerability, and Efficacy of an iPS Cell-based Therapy for Recessive Dystrophic Epidermolysis Bullosa Delivered with a Spray on Skin Device
Grant	Defining the role of innate immune cells in the early stages of immune surveillance of skin cancer by using a novel model that allows in vivo imaging of the immunoediting process.
Academic Article	The Development of an Advanced Model for Multilayer Human Skin Reconstruction In Vivo.

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