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Search Results to Dennis R Roop

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Roop, Dennis

One or more keywords matched the following items that are connected to Roop, Dennis

Item Type	Name
Academic Article	Proto-oncogene expression during two-stage carcinogenesis in mouse skin.
Academic Article	Evidence that deoxyribonucleic acid sequences flanking the ovalbumin gene are not transcribed.
Academic Article	Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture.
Academic Article	Definition of the 5' and 3' ends of transcripts of the ovalbumin gene.
Academic Article	Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens.
Academic Article	Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas.
Academic Article	Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.
Academic Article	Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.
Academic Article	Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion.
Academic Article	Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors.
Academic Article	Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Academic Article	Multiple defects and perinatal death in mice deficient in follistatin.
Academic Article	Dissecting molecular carcinogenesis: development of transgenic mouse models by epidermal gene targeting.
Academic Article	Epidermis: an attractive target tissue for gene therapy.
Academic Article	Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.
Academic Article	Heterogeneous initiation regions for transcription of the chicken ovomucoid gene.
Academic Article	Multistage skin carcinogenesis in transgenic mice.
Academic Article	Structure and expression of a chicken gene coding for U1 RNA.
Academic Article	Keratin gene expression in mouse epidermis and cultured epidermal cells.
Academic Article	The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.
Academic Article	Definition of the transcription unit of the natural ovalbumin gene.
Academic Article	Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.
Academic Article	Development of transgenic mouse models of skin carcinogenesis: potential applications.
Academic Article	Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.
Academic Article	Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene.
Academic Article	Transgenic models of skin diseases.
Academic Article	The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression.
Academic Article	Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Academic Article	Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Academic Article	Transduction of a preselected population of human epidermal stem cells: consequences for gene therapy.
Academic Article	Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Academic Article	Characterization of loricrin regulation in vitro and in transgenic mice.
Academic Article	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.
Academic Article	Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains.
Academic Article	Delayed wound healing in keratin 6a knockout mice.
Academic Article	Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders.
Academic Article	An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy.
Academic Article	Immunological gene therapy approaches for malignant melanoma. 1. Tumor-immunological background.
Academic Article	Immunological gene therapy approaches for malignant melanoma. 2. Preclinical studies and clinical strategies.
Academic Article	Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors.
Academic Article	In utero activation of K5.CrePR1 induces gene deletion.
Academic Article	Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.
Academic Article	Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.
Academic Article	Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox.
Academic Article	The ovalbumin gene: organization, structure, transcription, and regulation.
Academic Article	p63 is the molecular switch for initiation of an epithelial stratification program.
Academic Article	p63 and epithelial appendage development.
Academic Article	Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes.
Academic Article	p63 is a p53 homologue required for limb and epidermal morphogenesis.
Academic Article	Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Academic Article	The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.
Academic Article	p63 induces key target genes required for epidermal morphogenesis.
Academic Article	Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function.
Academic Article	An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Academic Article	Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.
Academic Article	Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.
Academic Article	The malignant conversion step of mouse skin carcinogenesis.
Academic Article	Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
Academic Article	Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Academic Article	The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression.
Academic Article	Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression.
Academic Article	Regulation of keratin gene expression during differentiation of epidermal and vaginal epithelial cells.
Academic Article	Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.
Academic Article	Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis.
Academic Article	SKI knockdown inhibits human melanoma tumor growth in vivo.
Academic Article	In situ hybridization analysis of keratin gene expression in human ameloblastomas.
Academic Article	Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis.
Academic Article	Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis.
Academic Article	Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.
Academic Article	Structure of a gene for the human epidermal 67-kDa keratin.
Academic Article	Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo.
Academic Article	Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Academic Article	Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.
Academic Article	The ovalbumin gene: transcriptional regulation by estrogen.
Academic Article	Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium.
Academic Article	A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.
Academic Article	Aurora kinase-A deficiency during skin development impairs cell division and stratification.
Academic Article	The expression and modulation of IL-1 alpha in murine keratinocytes.
Academic Article	Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene.
Academic Article	Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing.
Academic Article	Retinoic acid suppression of loricrin expression in reconstituted human skin cultured at the liquid-air interface.
Academic Article	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy.
Academic Article	Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network.
Academic Article	Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Academic Article	Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3.
Academic Article	IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Academic Article	Development of transgenic mice that inducibly express an active form of c-Src in the epidermis.
Academic Article	Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.
Academic Article	Inducible mouse models for inherited skin diseases: implications for skin gene therapy.
Academic Article	Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Academic Article	Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
Academic Article	Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
Academic Article	Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid.
Academic Article	Adenovirus-mediated ex vivo immunogene and in vivo combination gene therapy strategies induce a systemic anti-tumor immune defense in the mouse B16 melanoma model.
Academic Article	Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.
Academic Article	Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.
Academic Article	Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.
Academic Article	The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.
Academic Article	p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Academic Article	Down-regulation of p63 is required for epidermal UV-B-induced apoptosis.
Academic Article	Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders.
Academic Article	Keratin 6 is not essential for mammary gland development.
Academic Article	Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Academic Article	Regulated cutaneous gene delivery: the skin as a bioreactor.
Academic Article	The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes.
Academic Article	Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line.
Academic Article	The role of p63 in development and differentiation of the epidermis.
Academic Article	Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease.
Academic Article	Plasma membrane assays and three-compartment image cytometry for high content screening.
Academic Article	Double-inducible gene activation system for caspase 3 and 9 in epidermis.
Academic Article	TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis.
Academic Article	p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.
Academic Article	Genetically engineered mouse models for skin research: taking the next step.
Academic Article	IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
Academic Article	The molecular biology of intermediate filaments.
Academic Article	Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene.
Academic Article	Nrf2 links epidermal barrier function with antioxidant defense.
Academic Article	ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.
Academic Article	Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.
Academic Article	Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.
Academic Article	Molecular and cellular biology of intermediate filaments.
Academic Article	The gene for mouse epidermal filaggrin precursor. Its partial characterization, expression, and sequence of a repeating filaggrin unit.
Academic Article	Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors.
Concept	Genes, Regulator
Concept	Genomic Library
Concept	Transgenes
Concept	DNA, Recombinant
Concept	Genes, Reporter
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Profiling
Concept	Genes, Lethal
Concept	Gene Amplification
Concept	Multigene Family
Concept	Genes, Tumor Suppressor
Concept	Oncogenes
Concept	Gene Expression
Concept	Polymorphism, Single Nucleotide
Concept	Proto-Oncogenes
Concept	Genes, Dominant
Concept	Sequence Homology
Concept	Gene Knock-In Techniques
Concept	Gene Targeting
Concept	Nuclear Localization Signals
Concept	Open Reading Frames
Concept	Genes
Concept	Amino Acid Sequence
Concept	Lac Operon
Concept	Genes, fos
Concept	Genes, myc
Concept	Gene Expression Regulation, Neoplastic
Concept	Sequence Homology, Nucleic Acid
Concept	Genes, bcl-2
Concept	Molecular Structure
Concept	Gene Deletion
Concept	Gene Silencing
Concept	Base Sequence
Concept	Alleles
Concept	Genes, Recessive
Concept	Gene Knockdown Techniques
Concept	Gene Transfer Techniques
Concept	Molecular Sequence Data
Concept	Gene Expression Regulation, Developmental
Concept	Genes, ras
Concept	Repetitive Sequences, Nucleic Acid
Concept	Gene Expression Regulation
Concept	Genes, p53
Concept	RNA Splice Sites
Academic Article	Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.
Academic Article	XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer.
Academic Article	MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells.
Academic Article	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Academic Article	A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.
Academic Article	Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
Academic Article	Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for?the Loss of Loricrin.
Academic Article	Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
Academic Article	Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease.
Grant	REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
Grant	The consequences of loricrin deficiency on epidermal barrier function
Grant	INDUCIBLE MOUSE MODELS FOR SKIN AND HEAD AND NECK CANCER
Grant	TESTING GENE THERAPY FOR EPIDERMOLYSIS BULLOSA SIMPLEX
Grant	Regulation and Function of Keratins in the Epidermis
Grant	Targeting Oncogene Expression to Skin in Transgenic Mice
Grant	TARGETING HUMAN PAPILLOMA VIRUS GENE EXPRESSION IN MICE
Grant	Molecular Mechanisms of Skin and Appendage Development
Grant	Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
Grant	REGULATION AND FUNCTION OF A MAJOR CELL ENVELOPE PROTEIN
Concept	Transcriptome
Grant	Exploring Alternative iPS Cell Therapies for Recessive Dystrophic Epidermolysis Bullosa
Academic Article	Ancestral patterns of recessive dystrophic epidermolysis bullosa mutations in Hispanic populations suggest sephardic ancestry.

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