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Search Results to Charles A Dinarello

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Dinarello, Charles

One or more keywords matched the following items that are connected to Dinarello, Charles

Item Type	Name
Academic Article	Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.
Academic Article	Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta.
Academic Article	Interplay between redox status and inflammasome activation.
Academic Article	Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.
Academic Article	A signal for the caspase-1 inflammasome free of TLR.
Academic Article	Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Academic Article	Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity.
Academic Article	Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease.
Academic Article	Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans.
Academic Article	Inflammasome activation and IL-1? and IL-18 processing during infection.
Academic Article	NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1? processing via the NLRP1 inflammasome.
Academic Article	Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma.
Academic Article	Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Academic Article	The C3a receptor, caspase-1, and release of IL-1?.
Academic Article	IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis.
Academic Article	Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.
Academic Article	Inflammasome-independent regulation of IL-1-family cytokines.
Academic Article	Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra.
Academic Article	IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Academic Article	NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
Academic Article	Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.
Academic Article	IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation.
Academic Article	OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Academic Article	NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Academic Article	Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.
Concept	Inflammasomes
Academic Article	OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.
Academic Article	Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease.
Academic Article	Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma.
Academic Article	Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Academic Article	The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Academic Article	Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury.
Academic Article	The NLRP3 inflammasome inhibitor, OLT1177? , ameliorates experimental allergic asthma in mice.
Academic Article	Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers.
Academic Article	Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3.
Academic Article	Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions.
Academic Article	Pharmacologic inhibition of NLRP3 reduces the levels of a-synuclein and protects dopaminergic neurons in a model of Parkinson's disease.
Academic Article	NLRP3 and cancer: Pathogenesis and therapeutic opportunities.

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Inflammasomes