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Search Results to Robert Kuchta

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Kuchta, Robert

One or more keywords matched the following items that are connected to Kuchta, Robert

Item Type	Name
Academic Article	Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate.
Academic Article	Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination.
Academic Article	Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.
Academic Article	Calf thymus DNA polymerase alpha-primase: "communication" and primer-template movement between the two active sites.
Academic Article	Isotopic assays of viral polymerases and related proteins.
Academic Article	Interactions of calf thymus DNA polymerase alpha with primer/templates.
Academic Article	Arabinofuranosyl nucleotides are not chain-terminators during initiation of new strands of DNA by DNA polymerase alpha-primase.
Academic Article	3'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations.
Academic Article	Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection.
Academic Article	Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit.
Academic Article	Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase alpha during the synthesis of new DNA strands.
Academic Article	Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase.
Academic Article	Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells.
Academic Article	Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I).
Academic Article	Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.
Academic Article	Mechanism of DNA polymerase alpha inhibition by aphidicolin.
Academic Article	Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-).
Academic Article	Optimization of fragmentation conditions for microarray analysis of viral RNA.
Academic Article	Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates.
Academic Article	Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.
Academic Article	Interaction of herpes primase with the sugar of a NTP.
Academic Article	Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha.
Academic Article	Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha.
Academic Article	Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.
Academic Article	DNA primase. Processivity and the primase to polymerase alpha activity switch.
Academic Article	Mechanism and evolution of DNA primases.
Academic Article	Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment.
Academic Article	Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides.
Academic Article	Introduction to cancer chemotherapeutics.
Academic Article	Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation.
Academic Article	High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo.
Academic Article	Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase.
Academic Article	Photoinitiator nucleotide for quantifying nucleic Acid hybridization.
Academic Article	Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology.
Academic Article	Eukaryotic DNA primase.
Academic Article	Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs.
Academic Article	The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.
Academic Article	The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication.
Academic Article	Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase.
Academic Article	Herpes simplex virus-1 primase: a polymerase with extraordinarily low fidelity.
Academic Article	Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alpha.
Academic Article	DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity.
Academic Article	Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds.
Academic Article	A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues.
Academic Article	Inhibition of DNA primase by 9-beta-D-arabinofuranosyladenosine triphosphate.
Academic Article	Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates.
Academic Article	Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.
Academic Article	ConFind: a robust tool for conserved sequence identification.
Academic Article	Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase.
Academic Article	Real-time quantification of RNA polymerase activity using a "broken beacon".
Academic Article	Diagnostic microarray for influenza B viruses.
Academic Article	Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.
Academic Article	Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase.
Academic Article	Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates.
Academic Article	Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.
Academic Article	Kinetic and structural investigations of the replicative fidelity of the Klenow fragment.
Academic Article	B family DNA polymerases asymmetrically recognize pyrimidines and purines.
Academic Article	Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity.
Academic Article	Kinetic mechanism of DNA polymerase I (Klenow).
Concept	DNA, Viral
Concept	DNA, Bacterial
Concept	DNA Topoisomerases
Concept	DNA-Binding Proteins
Concept	DNA Polymerase II
Concept	DNA Helicases
Concept	RNA-Directed DNA Polymerase
Concept	DNA Damage
Concept	DNA-Directed DNA Polymerase
Concept	DNA Polymerase III
Concept	DNA
Concept	DNA Replication
Concept	DNA, Circular
Concept	DNA Primers
Concept	DNA-Directed RNA Polymerases
Concept	DNA Polymerase I
Concept	DNA Repair
Concept	DNA Polymerase beta
Concept	DNA, Single-Stranded
Concept	DNA Primase
Academic Article	The DNA helicase-primase complex as a target for herpes viral infection.
Academic Article	Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities.
Academic Article	Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated.
Academic Article	Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.
Academic Article	Nucleotide Analogues as Probes for DNA and RNA Polymerases.
Academic Article	Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach.
Grant	Mechanism of Herpes DNA Replication
Grant	A High-Throughput Assay for Influenza Replicase/RNA Polymerase Inhibitors
Grant	Development of Novel Nucleoside Triphosphate Prodrugs
Grant	Mechanism and Inhibition of Herpes Replication
Grant	DEVELOPMENT OF NOVEL GLYCOSYLATION INHIBITORS
Grant	Interaction of DNA Polymerase alpha with Novel Base-Pairs
Grant	Mechanism of DNA Polymerase Alpha-Primase
Academic Article	Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase.
Concept	DNA, B-Form
Concept	DNA Polymerase gamma

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