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Search Results to Andrew M Thorburn

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Thorburn, Andrew

One or more keywords matched the following items that are connected to Thorburn, Andrew

Item Type	Name
Academic Article	An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells.
Academic Article	Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen.
Academic Article	Mediation of the DCC apoptotic signal by DIP13 alpha.
Academic Article	A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells.
Academic Article	Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.
Academic Article	Induction of apoptosis by tumor cell-targeted toxins.
Academic Article	Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity.
Academic Article	Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice.
Academic Article	Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs).
Academic Article	The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation.
Academic Article	Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5.
Academic Article	Fatty acid synthase: a novel target for antiglioma therapy.
Academic Article	Autophagy in cancer: good, bad, or both?
Academic Article	Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death.
Academic Article	TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.
Academic Article	Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms.
Academic Article	BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Academic Article	Autophagy and metastasis: another double-edged sword.
Academic Article	Apoptosis induced by overexpression of hMSH2 or hMLH1.
Academic Article	Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.
Academic Article	The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
Academic Article	TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.
Academic Article	Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents.
Academic Article	Targeting autophagy during cancer therapy to improve clinical outcomes.
Academic Article	Interleukin-1a mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells.
Academic Article	Measurement of caspase activity in individual cells reveals differences in the kinetics of caspase activation between cells.
Academic Article	Targeting chaperone-mediated autophagy in cancer.
Academic Article	Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Academic Article	Inhibition of autophagy impairs tumor cell invasion in an organotypic model.
Academic Article	On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics.
Academic Article	Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.
Academic Article	Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer.
Academic Article	Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein.
Academic Article	N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1.
Academic Article	Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells.
Academic Article	The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
Academic Article	Apoptosis and anthracycline cardiotoxicity.
Academic Article	Caspase- and serine protease-dependent apoptosis by the death domain of FADD in normal epithelial cells.
Academic Article	Diphtheria toxin-epidermal growth factor fusion protein and Pseudomonas exotoxin-interleukin 13 fusion protein exert synergistic toxicity against human glioblastoma multiforme cells.
Academic Article	Death receptor-induced cell killing.
Academic Article	Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.
Academic Article	Regulation of HMGB1 release by autophagy.
Academic Article	EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins.
Academic Article	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling.
Academic Article	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding.
Academic Article	TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis.
Academic Article	Autophagy regulates selective HMGB1 release in tumor cells that are destined to die.
Academic Article	Autophagy and cancer therapy.
Academic Article	Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli.
Academic Article	Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Academic Article	The vitamin E analogue a-TEA stimulates tumor autophagy and enhances antigen cross-presentation.
Academic Article	Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
Academic Article	Modulation of pediatric brain tumor autophagy and chemosensitivity.
Academic Article	Apoptotic pathway manipulation.
Academic Article	Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer.
Concept	Central Nervous System Neoplasms
Concept	Tumor Burden
Concept	Brain Neoplasms
Concept	Lung Neoplasms
Concept	Uterine Neoplasms
Concept	Tumor Suppressor Protein p53
Concept	Prostatic Neoplasms
Concept	Neoplasm Metastasis
Concept	Urinary Bladder Neoplasms
Concept	Receptors, Tumor Necrosis Factor, Type I
Concept	Biomarkers, Tumor
Concept	Ovarian Neoplasms
Concept	Mammary Neoplasms, Animal
Concept	Neoplasms, Experimental
Concept	Colorectal Neoplasms
Concept	Neoplasm Proteins
Concept	Neoplasm Staging
Concept	Tumor Escape
Concept	Kidney Neoplasms
Concept	Drug Resistance, Neoplasm
Concept	Neoplasm Transplantation
Concept	Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Concept	Breast Neoplasms
Concept	Tumor Stem Cell Assay
Concept	Antibodies, Neoplasm
Concept	Tumor Cells, Cultured
Concept	Head and Neck Neoplasms
Concept	Neoplasms, Glandular and Epithelial
Concept	Tumor Necrosis Factor-alpha
Concept	Neoplasms
Concept	Receptors, Tumor Necrosis Factor
Concept	Colonic Neoplasms
Concept	Cell Line, Tumor
Concept	Tumor Suppressor Proteins
Concept	Endometrial Neoplasms
Academic Article	STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.
Academic Article	Autophagy and cancer therapy.
Academic Article	Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Academic Article	Inhibiting autophagy by shRNA knockdown: cautions and recommendations.
Academic Article	Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.
Academic Article	Targeting autophagy in breast cancer.
Academic Article	Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
Academic Article	Autophagy and its effects: making sense of double-edged swords.
Academic Article	Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors.
Academic Article	Targeting Autophagy in BRAF-Mutant Tumors.
Academic Article	Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.
Academic Article	Autophagy in malignant transformation and cancer progression.
Academic Article	Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics.
Academic Article	Recent insights into cell death and autophagy.
Academic Article	Casein kinase 1a-dependent feedback loop controls autophagy in RAS-driven cancers.
Academic Article	The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Academic Article	Measuring Autophagy in the Context of Cancer.
Academic Article	Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
Academic Article	Autophagy RIPs into cell death.
Academic Article	Therapeutic Targeting of Autophagy.
Academic Article	Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells.
Academic Article	A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.
Academic Article	Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.
Grant	Nuclear Signaling by TRADD
Grant	Therapeutic targeting of autophagy-dependent cancer
Grant	Autophagy regulation of prostate tumor development
Grant	Apoptosis Induction by Nuclear-localized TRADD
Grant	FADD Signaling in Cancer Cells
Grant	Prostate Cell Apoptosis by Androgen Receptor Cleavage
Grant	TRAIL Receptor Signaling in Human Tumors
Grant	Predoctoral Training Grant in Pharmacology
Academic Article	Targeting autophagy in cancer.
Academic Article	A caspase-independent way to kill cancer cells.
Academic Article	Targeting the Lysosome for Cancer Therapy.
Academic Article	Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.
Academic Article	Autophagy inhibition improves anti-cancer drugs via FOXO3a activation.
Academic Article	Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.
Grant	Changing the mechanism of cancer therapeutics
Academic Article	Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Concept	Tumor Microenvironment
Concept	Triple Negative Breast Neoplasms
Academic Article	Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.
Academic Article	Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations.
Academic Article	Circumventing autophagy inhibition.
Academic Article	Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients.
Academic Article	Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy.
Academic Article	Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
Academic Article	Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications.
Academic Article	A new mechanism for autophagy regulation of anti-tumor immune responses.
Academic Article	Autophagy and organelle homeostasis in cancer.
Academic Article	Enhancing anti-tumor immunity by autophagy inhibition.

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Neoplasms