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Search Results to Andrew M Thorburn

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Thorburn, Andrew

One or more keywords matched the following items that are connected to Thorburn, Andrew

Item Type	Name
Academic Article	An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells.
Academic Article	Mediation of the DCC apoptotic signal by DIP13 alpha.
Academic Article	Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.
Academic Article	Induction of apoptosis by tumor cell-targeted toxins.
Academic Article	Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs).
Academic Article	The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation.
Academic Article	Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5.
Academic Article	Fatty acid synthase: a novel target for antiglioma therapy.
Academic Article	Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death.
Academic Article	TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.
Academic Article	Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms.
Academic Article	BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Academic Article	Apoptosis induced by overexpression of hMSH2 or hMLH1.
Academic Article	Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.
Academic Article	TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro.
Academic Article	Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents.
Academic Article	Autophagy and apoptosis: what is the connection?
Academic Article	Measurement of caspase activity in individual cells reveals differences in the kinetics of caspase activation between cells.
Academic Article	On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics.
Academic Article	Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein.
Academic Article	Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells.
Academic Article	The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
Academic Article	Apoptosis and anthracycline cardiotoxicity.
Academic Article	Activation of caspase pathways during iron chelator-mediated apoptosis.
Academic Article	Caspase- and serine protease-dependent apoptosis by the death domain of FADD in normal epithelial cells.
Academic Article	Death receptor-induced cell killing.
Academic Article	Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.
Academic Article	Apoptosis and autophagy: regulatory connections between two supposedly different processes.
Academic Article	EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins.
Academic Article	Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.
Academic Article	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling.
Academic Article	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding.
Academic Article	TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis.
Academic Article	Autophagy and cancer therapy.
Academic Article	Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli.
Academic Article	Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Academic Article	The vitamin E analogue a-TEA stimulates tumor autophagy and enhances antigen cross-presentation.
Academic Article	Apoptotic pathway manipulation.
Concept	X-Linked Inhibitor of Apoptosis Protein
Concept	Apoptosis
Concept	CASP8 and FADD-Like Apoptosis Regulating Protein
Concept	Apoptosis Regulatory Proteins
Concept	Receptors, TNF-Related Apoptosis-Inducing Ligand
Concept	TNF-Related Apoptosis-Inducing Ligand
Academic Article	STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.
Academic Article	Autophagy and cell death.
Academic Article	Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Academic Article	Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Academic Article	Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.
Academic Article	RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis.
Academic Article	Recent insights into cell death and autophagy.
Academic Article	The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Academic Article	Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
Academic Article	Autophagy complexes cell death by necroptosis.
Academic Article	Autophagy RIPs into cell death.
Academic Article	Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells.
Academic Article	A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.
Grant	Nuclear Signaling by TRADD
Grant	Apoptosis Induction by Nuclear-localized TRADD
Grant	FADD Signaling in Cancer Cells
Grant	Prostate Cell Apoptosis by Androgen Receptor Cleavage
Grant	TRAIL Receptor Signaling in Human Tumors
Grant	Autophagy regulation of apoptosis and necroptosis within cell populations
Academic Article	A caspase-independent way to kill cancer cells.
Academic Article	Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.
Academic Article	FOXO3 links autophagy to apoptosis.
Academic Article	Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms.
Grant	Changing the mechanism of cancer therapeutics
Academic Article	Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients.
Academic Article	Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy.
Academic Article	Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications.

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Apoptosis