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Search Results to Paul J Rozance

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Rozance, Paul

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Dr. Rozance is the Scientific Director of the Perinatal Research Center and the PI/PD of the NICHD funded T32 Training Program in Perinatal Biology and Medicine. His laboratory has been continuously funded from the NIH since 2009 when the focus was on nutrient sensing by the pancreatic islet, insulin secretion, and beta-cell – endothelial cell cross talk. While continuing this area of research, he has broadened the scope of his work in several ways. First, he is engaged in research to demonstrate the role of “fetal-derived” signals, like glucagon, in regulating placental function and maternal metabolism, thus challenging the current dogma of the fetus as a passive participant in the regulation of its own growth. Second, he uses novel genetic approaches in sheep to investigate the role of specific gene products, like placental lactogen (chorionic sommatomamotropin) and glucose transporters, on placental function and liver and pancreatic islet development. Third, he investigates the response of the pancreatic islet to a variety of perinatal insults including genetic manipulations using both sheep and mouse models. Finally, he utilizes mouse models to determine the long-term impact of perinatal insults on the developmental origins of diabetes and metabolic disease. His basic physiological studies have led to his work focused on perinatal glucose metabolism, neonatal hypoglycemia and neonatal hyperglycemia.

One or more keywords matched the following items that are connected to Rozance, Paul

Item Type	Name
Academic Article	Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.
Academic Article	Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect.
Academic Article	Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells.
Academic Article	Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Academic Article	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Academic Article	Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus.
Academic Article	Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep.
Academic Article	Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.
Academic Article	Consequences of a compromised intrauterine environment on islet function.
Academic Article	Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep.
Academic Article	A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.
Academic Article	Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep.
Academic Article	Reductions in insulin concentrations and ?-cell mass precede growth restriction in sheep fetuses with placental insufficiency.
Academic Article	Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ?-cell mass in fetal sheep.
Academic Article	Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus.
Academic Article	An animal model of placental insufficiency-induced intrauterine growth restriction.
Academic Article	Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.
Academic Article	Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation.
Academic Article	Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus.
Academic Article	Prolonged infusion of amino acids increases leucine oxidation in fetal sheep.
Academic Article	Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep.
Academic Article	Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin.
Academic Article	Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic ?-cells.
Academic Article	Increased fetal insulin concentrations for one week fail to improve insulin secretion or ?-cell mass in fetal sheep with chronically reduced glucose supply.
Academic Article	Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas.
Concept	Sheep
Concept	Sheep, Domestic
Academic Article	Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted fetal sheep.
Academic Article	Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep.
Academic Article	A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia.
Academic Article	Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus.
Academic Article	Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep.
Academic Article	Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.
Academic Article	Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.
Academic Article	Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.
Academic Article	Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle.
Academic Article	Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.
Academic Article	Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.
Academic Article	Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep.
Academic Article	Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.
Academic Article	Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.
Grant	Nutrient coordination of pancreatic vasculature and B-cells
Academic Article	Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep.
Academic Article	Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep.
Academic Article	Pulsatile hyperglycemia increases insulin secretion but not pancreatic ?-cell mass in intrauterine growth-restricted fetal sheep.
Academic Article	A 1?week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep.
Academic Article	Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates.
Academic Article	Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.
Academic Article	Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.
Academic Article	Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb.
Academic Article	Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep.
Academic Article	Reduced Na+ K+ -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity.
Academic Article	A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ? Cells in Late-Gestation Sheep.
Academic Article	In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep.
Academic Article	Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.
Academic Article	Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization.
Academic Article	Impact of chorionic somatomammotropin RNA interference on uterine blood flow and placental glucose uptake in the absence of intrauterine growth restriction.
Academic Article	Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep.
Academic Article	IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.
Academic Article	Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth.
Academic Article	Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
Academic Article	Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency.
Academic Article	Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.
Academic Article	CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction.
Academic Article	Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep.
Academic Article	A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number.
Academic Article	Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.
Academic Article	In vivo investigation of ruminant placenta function and physiology-a review.
Academic Article	Uptake of Phosphate, Calcium, and Vitamin D by the Pregnant Uterus of Sheep in Late Gestation: Regulation by Chorionic Somatomammotropin Hormone.
Academic Article	Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.
Academic Article	Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep.
Academic Article	Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep.
Academic Article	Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
Academic Article	Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
Academic Article	Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.
Grant	Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretion

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