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Search Results to Paul J Rozance

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Rozance, Paul

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Dr. Rozance is the Scientific Director of the Perinatal Research Center and the PI/PD of the NICHD funded T32 Training Program in Perinatal Biology and Medicine. His laboratory has been continuously funded from the NIH since 2009 when the focus was on nutrient sensing by the pancreatic islet, insulin secretion, and beta-cell – endothelial cell cross talk. While continuing this area of research, he has broadened the scope of his work in several ways. First, he is engaged in research to demonstrate the role of “fetal-derived” signals, like glucagon, in regulating placental function and maternal metabolism, thus challenging the current dogma of the fetus as a passive participant in the regulation of its own growth. Second, he uses novel genetic approaches in sheep to investigate the role of specific gene products, like placental lactogen (chorionic sommatomamotropin) and glucose transporters, on placental function and liver and pancreatic islet development. Third, he investigates the response of the pancreatic islet to a variety of perinatal insults including genetic manipulations using both sheep and mouse models. Finally, he utilizes mouse models to determine the long-term impact of perinatal insults on the developmental origins of diabetes and metabolic disease. His basic physiological studies have led to his work focused on perinatal glucose metabolism, neonatal hypoglycemia and neonatal hyperglycemia.

One or more keywords matched the following items that are connected to Rozance, Paul

Item Type	Name
Academic Article	Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.
Academic Article	Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect.
Academic Article	Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells.
Academic Article	Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Academic Article	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Academic Article	Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep.
Academic Article	Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.
Academic Article	Continuous glucose monitoring for diagnosis and treatment of neonatal hypoglycemia.
Academic Article	Glucose metabolism in the preterm infant.
Academic Article	Neonatal hypoglycemia--answers, but more questions.
Academic Article	A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.
Academic Article	Reductions in insulin concentrations and ?-cell mass precede growth restriction in sheep fetuses with placental insufficiency.
Academic Article	Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ?-cell mass in fetal sheep.
Academic Article	Hypoglycemia in newborn infants: Features associated with adverse outcomes.
Academic Article	An animal model of placental insufficiency-induced intrauterine growth restriction.
Academic Article	Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction.
Academic Article	Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation.
Academic Article	Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus.
Academic Article	Describing hypoglycemia--definition or operational threshold?
Academic Article	Prolonged infusion of amino acids increases leucine oxidation in fetal sheep.
Academic Article	Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin.
Academic Article	Increased fetal insulin concentrations for one week fail to improve insulin secretion or ?-cell mass in fetal sheep with chronically reduced glucose supply.
Concept	Glucose Transporter Type 3
Concept	Glucose Transporter Type 1
Concept	Glucose Clamp Technique
Concept	Glucose Transport Proteins, Facilitative
Concept	Blood Glucose
Concept	Glucose-6-Phosphatase
Concept	Blood Glucose Self-Monitoring
Concept	Glucose
Academic Article	Update on neonatal hypoglycemia.
Academic Article	Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus.
Academic Article	Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.
Academic Article	Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management.
Academic Article	Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children.
Academic Article	Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.
Academic Article	A Sweet Addition for the Treatment of Neonatal Hypoglycemia.
Academic Article	50 Years Ago in The Journal of Pediatrics: Perinatal Stress and the Premature Neonate. II. Effect of Fluid and Calorie Deprivation on Blood Glucose.
Academic Article	Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction.
Academic Article	Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.
Academic Article	Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.
Academic Article	Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.
Academic Article	Does dextrose gel prevent treatment failure in infants with neonatal hypoglycaemia?
Academic Article	50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy.
Academic Article	Searching for the Best Oral Treatment for Hypoglycemic Newborns.
Academic Article	Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group.
Academic Article	Reply to the Letter to the Editor "The Postnatal Glucose Concentration Nadir Is Not Abnormal and Does Not Need to Be Treated".
Academic Article	Pulsatile hyperglycemia increases insulin secretion but not pancreatic ?-cell mass in intrauterine growth-restricted fetal sheep.
Academic Article	A 1?week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep.
Academic Article	Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'.
Academic Article	Alert Newborn Infants Are Ready to Feed and Raise Their Glucose Concentration.
Academic Article	Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.
Academic Article	Hypoglycemia in the Newborn.
Academic Article	Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.
Academic Article	Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal ?-Cell Development in C57BL/6 Mice.
Academic Article	A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ? Cells in Late-Gestation Sheep.
Academic Article	The GLOW Study does not light up the true Pediatric Endocrine Society recommendations for management of hypoglycemia in newborns.
Academic Article	Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.
Academic Article	Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.
Academic Article	Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization.
Academic Article	Impact of chorionic somatomammotropin RNA interference on uterine blood flow and placental glucose uptake in the absence of intrauterine growth restriction.
Academic Article	Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep.
Academic Article	Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
Academic Article	Real-time continuous glucose monitoring in preterm infants (react): An International, open-label, randomised, controlled trial.
Academic Article	CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction.
Academic Article	Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.
Academic Article	Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.
Academic Article	Re-examination of the estimated average requirement for carbohydrate intake during pregnancy: Addition of placental glucose consumption.
Academic Article	Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
Academic Article	Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
Academic Article	Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.
Academic Article	Metabolic and fecal microbial changes in adult fetal growth restricted mice.

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