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Search Results to Paul J Rozance

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overview Dr. Rozance is the Scientific Director of the Perinatal Research Center and the PI/PD of the NICHD funded T32 Training Program in Perinatal Biology and Medicine. His laboratory has been continuously funded from the NIH since 2009 when the focus was on nutrient sensing by the pancreatic islet, insulin secretion, and beta-cell – endothelial cell cross talk. While continuing this area of research, he has broadened the scope of his work in several ways. First, he is engaged in research to demonstrate the role of “fetal-derived” signals, like glucagon, in regulating placental function and maternal metabolism, thus challenging the current dogma of the fetus as a passive participant in the regulation of its own growth. Second, he uses novel genetic approaches in sheep to investigate the role of specific gene products, like placental lactogen (chorionic sommatomamotropin) and glucose transporters, on placental function and liver and pancreatic islet development. Third, he investigates the response of the pancreatic islet to a variety of perinatal insults including genetic manipulations using both sheep and mouse models. Finally, he utilizes mouse models to determine the long-term impact of perinatal insults on the developmental origins of diabetes and metabolic disease. His basic physiological studies have led to his work focused on perinatal glucose metabolism, neonatal hypoglycemia and neonatal hyperglycemia.

One or more keywords matched the following items that are connected to Rozance, Paul

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Academic Article Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect.
Academic Article Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells.
Academic Article Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Academic Article Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ?-cell mass in fetal sheep.
Academic Article An animal model of placental insufficiency-induced intrauterine growth restriction.
Academic Article Differential effects of chronic pulsatile versus chronic constant maternal hyperglycemia on fetal pancreatic ?-cells.
Academic Article Increased fetal insulin concentrations for one week fail to improve insulin secretion or ?-cell mass in fetal sheep with chronically reduced glucose supply.
Academic Article Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus.
Academic Article Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep.
Academic Article Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep.
Academic Article Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
Academic Article Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency.
Grant Nutrient coordination of pancreatic vasculature and B-cells
Academic Article Pulsatile hyperglycemia increases insulin secretion but not pancreatic ?-cell mass in intrauterine growth-restricted fetal sheep.
Academic Article A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ? Cells in Late-Gestation Sheep.
Academic Article Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.
Academic Article Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep.
Academic Article Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
Academic Article Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.
Academic Article Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
Grant Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretion
Grant Fetal glucagon links fetal metabolism with uterine blood flow and placental nutrient transfer by inhibiting placental lactogen secretion

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