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Search Results to Kenneth Norman MacLean

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MacLean, Kenneth

One or more keywords matched the following items that are connected to MacLean, Kenneth

Item Type	Name
Academic Article	The human cystathionine beta-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms.
Academic Article	Plasma albumin cysteinylation is regulated by cystathionine beta-synthase.
Academic Article	Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.
Academic Article	Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase.
Academic Article	Integrated stress response modulates cellular redox state via induction of cystathionine ?-lyase: cross-talk between integrated stress response and thiol metabolism.
Academic Article	Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Academic Article	Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae.
Academic Article	Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.
Academic Article	The dominant role of Sp1 in regulating the cystathionine beta-synthase -1a and -1b promoters facilitates potential tissue-specific regulation by Kruppel-like factors.
Academic Article	High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations.
Academic Article	Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding.
Academic Article	A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.
Academic Article	Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria.
Concept	Cystathionine beta-Synthase
Concept	Cystathionine
Concept	Cystathionine gamma-Lyase
Academic Article	Altered hepatic sulfur metabolism in cystathionine ?-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.
Academic Article	Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.
Academic Article	Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Grant	Phase 1/2 of Taurine in Cystathionine Beta-Synthase Deficient Homocystinuria
Academic Article	Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Academic Article	Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ?-synthase-deficient homocystinuria.
Academic Article	Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ?-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.
Academic Article	Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium.
Academic Article	Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Academic Article	Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis.
Academic Article	Analysis of differential neonatal lethality in cystathionine ?-synthase deficient mouse models using metabolic profiling.

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