Item Type | Name |
Academic Article
|
A DNA architectural protein couples cellular physiology and DNA topology in Escherichia coli.
|
Academic Article
|
Multivalent mechanism of membrane insertion by the FYVE domain.
|
Academic Article
|
Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP.
|
Academic Article
|
Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch.
|
Academic Article
|
Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain.
|
Academic Article
|
Structural insights into histone demethylation by JMJD2 family members.
|
Academic Article
|
Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate.
|
Academic Article
|
Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling.
|
Academic Article
|
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
|
Academic Article
|
pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers.
|
Academic Article
|
The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.
|
Academic Article
|
NMR assignments and histone specificity of the ING2 PHD finger.
|
Academic Article
|
HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.
|
Academic Article
|
ING family of tumor suppressors.
|
Academic Article
|
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications.
|
Academic Article
|
PHD fingers: epigenetic effectors and potential drug targets.
|
Academic Article
|
Phosphatidylinositol 3-phosphate recognition by the FYVE domain.
|
Academic Article
|
Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
|
Academic Article
|
Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.
|
Academic Article
|
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.
|
Academic Article
|
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.
|
Academic Article
|
Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain.
|
Academic Article
|
Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.
|
Academic Article
|
Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.
|
Academic Article
|
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
|
Academic Article
|
Emerging methodologies to investigate lipid-protein interactions.
|
Academic Article
|
Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.
|
Academic Article
|
Multivalent recognition of histone tails by the PHD fingers of CHD5.
|
Academic Article
|
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.
|
Academic Article
|
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.
|
Academic Article
|
Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain.
|
Academic Article
|
Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate.
|
Academic Article
|
Structural mechanism of endosome docking by the FYVE domain.
|
Academic Article
|
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.
|
Academic Article
|
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.
|
Academic Article
|
Investigation of the binding geometry of a peripheral membrane protein.
|
Academic Article
|
Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes.
|
Academic Article
|
Molecular mechanism of membrane docking by the Vam7p PX domain.
|
Academic Article
|
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
|
Academic Article
|
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.
|
Academic Article
|
Membrane insertion of the FYVE domain is modulated by pH.
|
Academic Article
|
Structural insight into histone recognition by the ING PHD fingers.
|
Academic Article
|
Handpicking epigenetic marks with PHD fingers.
|
Academic Article
|
Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.
|
Academic Article
|
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression.
|
Academic Article
|
MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes.
|
Academic Article
|
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
|
Concept
|
Homeodomain Proteins
|
Concept
|
Adaptor Proteins, Signal Transducing
|
Concept
|
Proto-Oncogene Proteins c-myc
|
Concept
|
Vesicular Transport Proteins
|
Concept
|
Membrane Proteins
|
Concept
|
Monomeric Clathrin Assembly Proteins
|
Concept
|
DNA-Binding Proteins
|
Concept
|
Oncogene Proteins, Fusion
|
Concept
|
Nuclear Pore Complex Proteins
|
Concept
|
Escherichia coli Proteins
|
Concept
|
Green Fluorescent Proteins
|
Concept
|
ras Proteins
|
Concept
|
Recombinant Fusion Proteins
|
Concept
|
SNARE Proteins
|
Concept
|
Inhibitor of Apoptosis Proteins
|
Concept
|
Viral Nonstructural Proteins
|
Concept
|
Plant Proteins
|
Concept
|
Fungal Proteins
|
Concept
|
Saccharomyces cerevisiae Proteins
|
Concept
|
Carrier Proteins
|
Concept
|
Chromosomal Proteins, Non-Histone
|
Concept
|
Cell Cycle Proteins
|
Concept
|
Nuclear Proteins
|
Concept
|
Recombinant Proteins
|
Concept
|
Neoplasm Proteins
|
Concept
|
Drosophila Proteins
|
Concept
|
Proto-Oncogene Proteins p21(ras)
|
Concept
|
Intracellular Signaling Peptides and Proteins
|
Concept
|
Qc-SNARE Proteins
|
Concept
|
Adaptor Proteins, Vesicular Transport
|
Concept
|
Apoptosis Regulatory Proteins
|
Concept
|
Nucleocapsid Proteins
|
Concept
|
Proto-Oncogene Proteins
|
Concept
|
Proto-Oncogene Proteins c-abl
|
Concept
|
Nerve Tissue Proteins
|
Concept
|
Tumor Suppressor Proteins
|
Concept
|
RNA-Binding Proteins
|
Concept
|
Viral Proteins
|
Concept
|
Intercellular Signaling Peptides and Proteins
|
Concept
|
Repressor Proteins
|
Concept
|
Proteins
|
Concept
|
Microtubule-Associated Proteins
|
Concept
|
F-Box Proteins
|
Academic Article
|
Molecular basis for chromatin binding and regulation of MLL5.
|
Academic Article
|
Dido3 PHD modulates cell differentiation and division.
|
Academic Article
|
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
|
Academic Article
|
Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.
|
Academic Article
|
Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility.
|
Academic Article
|
Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.
|
Academic Article
|
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
|
Academic Article
|
Inhibition of histone binding by supramolecular hosts.
|
Academic Article
|
Towards understanding methyllysine readout.
|
Academic Article
|
Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.
|
Academic Article
|
O-GlcNAcylation of MLL5? is essential for MLL5?-AP-1 transcription complex assembly at the HPV16/18-long control region.
|
Academic Article
|
An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.
|
Academic Article
|
Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
|
Academic Article
|
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes.
|
Academic Article
|
Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
|
Academic Article
|
Regulation of Methyllysine Readers through Phosphorylation.
|
Academic Article
|
The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation.
|
Academic Article
|
G9a-mediated methylation of ERa links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.
|
Academic Article
|
The Taf14 YEATS domain is a reader of histone crotonylation.
|
Academic Article
|
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
|
Academic Article
|
Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers.
|
Academic Article
|
Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive.
|
Academic Article
|
Insights into newly discovered marks and readers of epigenetic information.
|
Academic Article
|
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
|
Academic Article
|
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
|
Academic Article
|
PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility.
|
Academic Article
|
Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
|
Grant
|
Membrane Targeting by PI-binding Domains
|
Grant
|
Epigenetic regulation by PHF1
|
Grant
|
STRUCTURE AND FUNCTION OF FYVE DOMAINS
|
Grant
|
Molecular analysis of methylated p53
|
Grant
|
Structural basis of signaling by ING2 PHD
|
Grant
|
Structure and Function of the Phox Domain
|
Grant
|
Molecular mechanism of chromatin targeting by BRPF1
|
Grant
|
Molecular analysis of CHD4
|
Academic Article
|
A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
|
Academic Article
|
Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
|
Academic Article
|
Architecture of PRC2 Holo Complexes.
|
Academic Article
|
Switching 53BP1 on and off via Tudors.
|
Academic Article
|
The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
|
Academic Article
|
Structural insights into the p-p-p stacking mechanism and DNA-binding activity of the YEATS domain.
|
Academic Article
|
Mechanism for autoinhibition and activation of the MORC3 ATPase.
|
Academic Article
|
Strategies for Generating Modified Nucleosomes: Applications within Structural Biology Studies.
|
Concept
|
Autophagy-Related Proteins
|
Concept
|
Polycomb-Group Proteins
|
Academic Article
|
MORC3 Is a Target of the Influenza A Viral Protein NS1.
|
Academic Article
|
Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.
|
Academic Article
|
E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair.
|
Academic Article
|
Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.
|
Academic Article
|
TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark.
|
Academic Article
|
Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2.
|
Academic Article
|
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
|
Academic Article
|
Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
|
Academic Article
|
Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
|
Academic Article
|
Molecular mechanism of the MORC4 ATPase activation.
|
Academic Article
|
Protocol for Biochemical Analysis and Structure Determination of the ZZ Domain of the E3?Ubiquitin Ligase HERC2.
|
Academic Article
|
Characterization of functional disordered regions within chromatin-associated proteins.
|
Academic Article
|
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
|
Academic Article
|
Structural and biophysical characterization of the nucleosome-binding PZP domain.
|
Academic Article
|
Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).
|
Academic Article
|
The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
|
Academic Article
|
PI3K-a/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron.
|
Academic Article
|
Taf2 mediates DNA binding of Taf14.
|
Academic Article
|
A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.
|
Academic Article
|
Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
|
Academic Article
|
Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4.
|
Academic Article
|
Dietary polyphenols link extracellular histones and nonhistone proteins.
|
Academic Article
|
Catching BETs by viruses.
|
Academic Article
|
Protocol to identify drug-binding sites in proteins using solution NMR spectroscopy.
|
Academic Article
|
Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein.
|
Academic Article
|
Atypical histone targets of PHD fingers.
|
Academic Article
|
Non-histone binding functions of PHD fingers.
|
Academic Article
|
Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
|
Academic Article
|
Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation.
|