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Search Results to Justin J Brumbaugh

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One or more keywords matched the following properties of Brumbaugh, Justin

keywords Stem Cell Biology
overview Development is extraordinary feat in complex organisms. Numerous cell types with highly specific functions arise from a single cell, the zygote. During this process, the embryo must strike a fine balance between replenishing stem cell populations (i.e., self-renewal) and appropriate induction of specialized cells (differentiation). Remarkably, all of these decisions take place largely without changing the genomic content of the cells involved, which underscores the importance of intricate and dynamic regulatory mechanisms in development. Understanding these mechanisms is crucial for both basic science and medicine. Our lab seeks to develop and apply novel and innovative tools to study the molecular determinants of cell fate.

One or more keywords matched the following items that are connected to Brumbaugh, Justin

Item TypeName
Concept Neoplastic Stem Cells
Concept Induced Pluripotent Stem Cells
Concept Embryonic Stem Cells
Concept Pluripotent Stem Cells
Academic Article A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.
Concept Mouse Embryonic Stem Cells
Academic Article Reprogramming: identifying the mechanisms that safeguard cell identity.
Award or Honor Receipt Next Generation Leader
Academic Article Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.
Academic Article Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.
Academic Article Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.
Academic Article Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.
Academic Article Small molecules facilitate rapid and synchronous iPSC generation.
Academic Article F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
Academic Article Phosphorylation regulates human OCT4.
Academic Article Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells.
Academic Article The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
Academic Article Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.
Academic Article Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Academic Article DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.
Academic Article Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells.
Academic Article Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage.
Academic Article NANOG is multiply phosphorylated and directly modified by ERK2 and CDK1 in vitro.
Academic Article Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation.
Academic Article Proteomics and pluripotency.
Academic Article Proteomic and phosphoproteomic comparison of human ES and iPS cells.
Academic Article Higher-energy collision-activated dissociation without a dedicated collision cell.

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