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Search Results to Eszter Katalin Vladar

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Vladar, Eszter

One or more keywords matched the following properties of Vladar, Eszter

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Cilia

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Website: http://cilialab.com/ Our lungs are constantly bombarded by inhaled pathogens, allergens, toxins and debris. The airway epithelium is the first line of defense against these contaminants. It accomplishes this by acting as a selective physical barrier, by participating in immune surveillance and response, and by the directional movement of cilia that sweep contaminants adhered to the mucus layer out of the lungs. Epithelial dysfunction underlies disease phenotypes and promotes disease progression in chronic inflammatory airway conditions like cystic fibrosis, asthma and COPD – however, current treatments do not directly target or reverse dysfunction. Our work focuses on the multiciliated cells, which each contain hundreds of motile cilia. We use mice and primary mouse and human cell culture to study how multiciliated cells adopt their cell fate, build cilia and orient the cilia for directional clearance. We investigate the pathways that drive these processes during normal development and regeneration and study how they are misregulated in human disease. Our research has the potential to develop novel biomarkers and therapeutics for individuals suffering from chronic airway diseases.

One or more keywords matched the following items that are connected to Vladar, Eszter

Item Type	Name
Academic Article	Deuterosome-mediated centriole biogenesis.
Academic Article	Molecular characterization of centriole assembly in ciliated epithelial cells.
Academic Article	Microtubules enable the planar cell polarity of airway cilia.
Academic Article	Myb promotes centriole amplification and later steps of the multiciliogenesis program.
Academic Article	Planar cell polarity signaling: the developing cell's compass.
Academic Article	Loss of primary cilia correlates with cytologic severity in dysplastic melanocytic nevi.
Academic Article	Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells.
Academic Article	Observing planar cell polarity in multiciliated mouse airway epithelial cells.
Academic Article	Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.
Academic Article	Dishevelled links basal body docking and orientation in ciliated epithelial cells.
Academic Article	Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps.
Academic Article	Cyclin-dependent kinase control of motile ciliogenesis.
Academic Article	Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models.
Academic Article	Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
Academic Article	Ciliation Index Is a Useful Diagnostic Tool in Challenging Spitzoid Melanocytic Neoplasms.
Academic Article	Noncanonical Wnt planar cell polarity signaling in lung development and disease.
Academic Article	Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Academic Article	Aberrant Multiciliogenesis in Idiopathic Pulmonary Fibrosis.
Academic Article	A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.

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Cilia