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Search Results to Mamuka Kvaratskhelia

This is a "connection" page, showing the details of why an item matched the keywords from your search.


One or more keywords matched the following items that are connected to Kvaratskhelia, Mamuka

Item TypeName
Concept HIV Integrase
Concept Integrases
Concept HIV Integrase Inhibitors
Concept Integrase Inhibitors
Academic Article A new class of multimerization selective inhibitors of HIV-1 integrase.
Academic Article TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.
Academic Article The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Academic Article HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
Academic Article Structure of the Brd4 ET domain bound to a C-terminal motif from ?-retroviral integrases reveals a conserved mechanism of interaction.
Academic Article Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.
Academic Article The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Academic Article Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.
Academic Article HIV-1 Integrase-DNA Recognition Mechanisms.
Academic Article The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article Allosteric inhibition of HIV-1 integrase activity.
Academic Article BET proteins promote efficient murine leukemia virus integration at transcription start sites.
Academic Article Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.
Academic Article Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.
Academic Article HIV-1 integrase multimerization as a therapeutic target.
Academic Article The FACT Complex Promotes Avian Leukosis Virus DNA Integration.
Academic Article A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
Academic Article Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Academic Article Molecular mechanisms of retroviral integration site selection.
Academic Article Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Academic Article Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.
Academic Article Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.
Academic Article A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Academic Article Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.
Academic Article FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.
Academic Article Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.
Academic Article Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes.
Academic Article Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.
Academic Article An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.
Academic Article HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Academic Article Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.
Academic Article Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.
Academic Article Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.
Grant Multimeric HIV-1 Integrase Inhibitors
Grant Cellular Cofactors of Murine Leukemia Virus Integrase
Grant Structure and function of HIV-1 integrase
Grant Novel Assay for HIV-1 Integrase Inhibitors
Grant HIV-1 Integrase Structure and Function as a Therapeutic Target
Academic Article HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
Academic Article Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Academic Article An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Grant Multimeric HIV-1 Integrase Inhibitors
Academic Article HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Academic Article Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.
Academic Article Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Academic Article A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
Academic Article HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.

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