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Search Results to Lori Gail Sussel

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Sussel, Lori

One or more keywords matched the following items that are connected to Sussel, Lori

Item Type	Name
Academic Article	Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
Academic Article	The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.
Academic Article	Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine.
Academic Article	Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.
Academic Article	ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.
Concept	Cell Movement
Concept	Cell Dedifferentiation
Concept	Cell Death
Concept	Somatostatin-Secreting Cells
Concept	Pancreatic Polypeptide-Secreting Cells
Concept	Epithelial Cells
Concept	Cell Lineage
Concept	HeLa Cells
Concept	Cell Division
Concept	COS Cells
Concept	Enterochromaffin Cells
Concept	Cell Survival
Concept	Glucagon-Secreting Cells
Concept	Cell Cycle
Concept	Cell Transdifferentiation
Concept	Schwann Cells
Concept	NIH 3T3 Cells
Concept	Induced Pluripotent Stem Cells
Concept	Stem Cell Transplantation
Concept	Cell Line
Concept	Enteroendocrine Cells
Concept	Multipotent Stem Cells
Concept	Cell Differentiation
Concept	Pluripotent Stem Cells
Concept	Cell Line, Tumor
Concept	Insulin-Secreting Cells
Concept	Cells, Cultured
Concept	Stem Cells
Concept	Cell Hypoxia
Concept	Cell Proliferation
Concept	Cell Count
Academic Article	Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.
Academic Article	Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.
Academic Article	Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Academic Article	Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.
Academic Article	Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.
Academic Article	Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.
Academic Article	Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
Academic Article	Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Academic Article	The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
Academic Article	Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.
Academic Article	Engineering islets: lessons from stem cells and embryonic development.
Academic Article	A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo.
Academic Article	FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Academic Article	Gata6 is an important regulator of mouse pancreas development.
Academic Article	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Academic Article	Nkx2.2 regulates beta-cell function in the mature islet.
Academic Article	Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
Academic Article	Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine.
Academic Article	Ghrelin is dispensable for embryonic pancreatic islet development and differentiation.
Academic Article	Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
Academic Article	GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2.
Academic Article	Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.
Academic Article	Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
Academic Article	A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.
Academic Article	Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
Academic Article	Nkx2.2 repressor complex regulates islet ?-cell specification and prevents ?-to-a-cell reprogramming.
Academic Article	Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology.
Academic Article	Advances in pancreas development: generation informs regeneration.
Academic Article	Pancreatic ? cell dedifferentiation as a mechanism of diabetic ? cell failure.
Academic Article	Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.
Academic Article	Human ? cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Academic Article	Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population.
Academic Article	Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.
Academic Article	The endocrine pancreas: insights into development, differentiation, and diabetes.
Academic Article	Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas.
Academic Article	Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.
Academic Article	?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article	?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article	Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.
Academic Article	Noncoding RNAs in ? cell biology.
Academic Article	Epigenetic modifications and long noncoding RNAs influence pancreas development and function.
Academic Article	The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.
Academic Article	Pancreatic islet cell development and regeneration.
Academic Article	Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential.
Academic Article	Unique functions of Gata4 in mouse liver induction and heart development.
Academic Article	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.
Academic Article	?linc1 encodes a long noncoding RNA that regulates islet ?-cell formation and function.
Academic Article	The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.
Academic Article	Pancreatic ? cell identity requires continual repression of non-? cell programs.
Academic Article	LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ? cells.
Academic Article	Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.
Academic Article	Heterogeneity of the Pancreatic Beta Cell.
Grant	Single Cell Resolution Omics Analysis of T1D islets
Grant	The role of Gata 4 in exocrine pancreas development
Grant	Regulation of exocrine pancreas formation
Grant	Transcriptional regulation of exocrine development
Grant	Regulation of pancreatic islet cell fate
Grant	Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fate
Grant	Nkx2.2 and Gata6: regulation of islet development
Grant	Epigenetic events underlying Type I diabetes
Grant	GENETIC ANALYSIS OF MOUSE NKX-21 AND NKX-22 GENES
Grant	Long non-coding RNAs in Islet Cell Biology
Academic Article	Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells.
Academic Article	Gotta Have GATA for Human Pancreas Development.
Grant	Intersection of signaling pathways and transcription factors regulating islet development
Academic Article	Notch signaling dynamically regulates adult ? cell proliferation and maturity.
Academic Article	FISHing for ? Cells.
Concept	Human Embryonic Stem Cells
Concept	Neural Stem Cells
Concept	Single-Cell Analysis
Concept	Acinar Cells
Concept	HEK293 Cells
Academic Article	? Cell dysfunction during progression of metabolic syndrome to type 2 diabetes.
Academic Article	Murine Perinatal ?-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.
Academic Article	The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function.
Academic Article	A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development.
Grant	UC Denver Diabetes Research Center
Academic Article	Animal Models of Pancreas Development, Developmental Disorders, and Disease.
Academic Article	Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
Academic Article	Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ? cell specification.
Academic Article	An Ultradian Notch in Beta-Cell Development.
Grant	PTPN2 mutations affect islet beta cell susceptibility in T1D
Academic Article	Pancreatic ? cell regeneration: To ? or not to ?.
Academic Article	mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic ? Cell Function.
Academic Article	Groucho co-repressor proteins regulate ? cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.
Academic Article	Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ?-Cells.
Academic Article	Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
Academic Article	Islet Regeneration: Endogenous and Exogenous Approaches.
Academic Article	Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility.
Academic Article	From the dish to humans: A stem cell recipe for success.
Academic Article	Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes.
Academic Article	Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration.
Academic Article	Not the second fiddle: a cell development, identity, and function in health and diabetes.
Academic Article	Major ? cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.
Academic Article	Modulation of insulin secretion by RBFOX2-mediated alternative splicing.
Academic Article	PTPN2 Regulates Metabolic Flux to Affect ?-Cell Susceptibility to Inflammatory Stress.

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