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Search Results to Melanie G. Cree

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Cree, Melanie

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Type 2 Diabetes Mellitus

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I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	The interplay of autoimmunity and insulin resistance in type 1 diabetes.
Academic Article	Insulin resistance in type 2 diabetic youth.
Academic Article	Etiology of insulin resistance in youth with type 2 diabetes.
Concept	Diabetes Mellitus, Type 1
Concept	Diabetes Mellitus, Type 2
Academic Article	Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes.
Academic Article	Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes.
Academic Article	Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance.
Academic Article	Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined.
Academic Article	Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes.
Academic Article	Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes.
Academic Article	Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study.
Academic Article	Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction.
Academic Article	The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes.
Academic Article	Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.
Grant	Skeletal muscle diacylglycerol and sphingolipids: Impact of localization and species on insulin resistance in humans
Academic Article	Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies.
Academic Article	Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.
Academic Article	Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.
Grant	Intermuscular adipose tissue (IMAT): protagonist in sarcopenia and insulin resistance in humans
Academic Article	Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.
Academic Article	Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
Academic Article	Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.
Academic Article	Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes.
Academic Article	Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes.
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp.
Academic Article	Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
Academic Article	Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ?-Cell Function: Comparison of Responses In Youth And Adults.
Academic Article	Lack of Durable Improvements in ?-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test.
Academic Article	Impact of Gastric Banding Versus Metformin on ?-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes.
Academic Article	Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes.
Academic Article	?-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults.
Academic Article	Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes.
Grant	Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
Academic Article	Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes.
Academic Article	Obstructive Sleep Apnea, Glucose Tolerance, and ?-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study.
Academic Article	Precision and accuracy of hyperglycemic clamps in a multicenter study.
Academic Article	Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.
Academic Article	Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity.
Academic Article	Weight Management in Adolescents with Polycystic Ovary Syndrome.
Academic Article	Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ?-Cell Function.
Academic Article	Differential loss of ?-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study.
Academic Article	Youth-onset type 2 diabetes mellitus: an urgent challenge.
Academic Article	Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study.
Grant	Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)

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type 1 diabetes