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Search Results to Melanie G. Cree

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Cree, Melanie

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Insulin Resistance

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I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	The interplay of autoimmunity and insulin resistance in type 1 diabetes.
Academic Article	Insulin resistance in type 2 diabetic youth.
Academic Article	Etiology of insulin resistance in youth with type 2 diabetes.
Academic Article	The StatStrip glucose monitor is suitable for use during hyperinsulinemic euglycemic clamps in a pediatric population.
Academic Article	Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes.
Academic Article	Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes.
Academic Article	Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance.
Academic Article	Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids.
Academic Article	Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes.
Academic Article	Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes.
Academic Article	Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.
Academic Article	Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction.
Academic Article	Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood.
Academic Article	Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers.
Academic Article	The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes.
Academic Article	Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.
Academic Article	Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.
Grant	Skeletal muscle diacylglycerol and sphingolipids: Impact of localization and species on insulin resistance in humans
Academic Article	Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies.
Academic Article	Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome.
Academic Article	Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.
Grant	Intermuscular adipose tissue (IMAT): protagonist in sarcopenia and insulin resistance in humans
Academic Article	Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome.
Academic Article	Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity.
Academic Article	Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.
Academic Article	Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Intramuscular and liver triglycerides are increased in the elderly.
Academic Article	Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
Academic Article	Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay.
Academic Article	Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children.
Academic Article	Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides.
Academic Article	Insulin resistance, secretion and breakdown are increased 9 months following severe burn injury.
Academic Article	Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury.
Academic Article	Postburn trauma insulin resistance and fat metabolism.
Academic Article	Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment.
Academic Article	Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance.
Academic Article	Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate.
Academic Article	Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Academic Article	Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Academic Article	Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
Academic Article	A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.
Academic Article	Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report.
Grant	Do alterations in testosterone concentrations mediate improvements in insulin sensitivity and hepatic health via microbiota taxa abundance changes?
Grant	Do alterations in serum testosterone mediate systemic insulin sensitivity and hepatic health via the gut microbiota
Grant	Mechanism of insulin resistance in girls with polycystic ovary disease
Grant	The role of branched chain amino acid metabolism in muscle insulin resistance in youth with obesity and Polycystic ovarian syndrome
Grant	Role of androgens and obesity in insulin resistance and cardiovascular disease in PCOS
Grant	Modeling hepatic and adipose insulin sensitivity with stable isotope tracers during an oral glucose load
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp.
Academic Article	Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
Academic Article	Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ?-Cell Function: Comparison of Responses In Youth And Adults.
Academic Article	Lack of Durable Improvements in ?-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test.
Academic Article	Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).
Academic Article	Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.
Academic Article	Impact of Gastric Banding Versus Metformin on ?-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes.
Academic Article	Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome.
Academic Article	Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.
Academic Article	Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.
Academic Article	Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents.
Academic Article	Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers.
Grant	Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
Academic Article	Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration.
Academic Article	Weight Management in Adolescents with Polycystic Ovary Syndrome.
Academic Article	Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ?-Cell Function.
Academic Article	Differential loss of ?-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study.
Academic Article	In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome.
Academic Article	Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity.
Academic Article	Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model.
Academic Article	Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.
Academic Article	Estimating insulin sensitivity and ?-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model.
Academic Article	Insulin sensitivity, body composition and bone mineral density after testosterone treatment in transgender youth with and without prior GnRH agonist therapy.

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Insulin Sensitivity