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Cree, Melanie

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I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	Insulin resistance in type 2 diabetic youth.
Academic Article	Etiology of insulin resistance in youth with type 2 diabetes.
Concept	Adolescent Medicine
Concept	Adolescent
Academic Article	The StatStrip glucose monitor is suitable for use during hyperinsulinemic euglycemic clamps in a pediatric population.
Academic Article	Method for controlled mitochondrial perturbation during phosphorus MRS in children.
Academic Article	Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes.
Academic Article	Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes.
Academic Article	Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance.
Academic Article	Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids.
Academic Article	Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined.
Academic Article	Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes.
Academic Article	Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes.
Academic Article	Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children.
Academic Article	Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study.
Academic Article	Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.
Academic Article	Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction.
Academic Article	Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood.
Academic Article	Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers.
Academic Article	The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes.
Academic Article	Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.
Academic Article	Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.
Academic Article	Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies.
Academic Article	Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.
Academic Article	Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome.
Academic Article	Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity.
Academic Article	Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.
Academic Article	Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay.
Academic Article	Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children.
Academic Article	Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury.
Academic Article	Recovery of labeled CO2 from acetate in severely burned children.
Academic Article	Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate.
Academic Article	Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Academic Article	Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Academic Article	Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
Academic Article	Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.
Academic Article	A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.
Academic Article	Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report.
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp.
Academic Article	Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes.
Academic Article	Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test.
Academic Article	Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity.
Academic Article	Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).
Academic Article	Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.
Academic Article	Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.
Academic Article	Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.
Academic Article	Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity.
Academic Article	Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota.
Academic Article	Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.
Academic Article	Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome.
Academic Article	Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents.
Academic Article	Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes.
Academic Article	Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome.
Academic Article	Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers.
Academic Article	Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index.
Academic Article	?-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults.
Academic Article	Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome.
Academic Article	Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes.
Academic Article	Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes.
Academic Article	Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome.
Academic Article	Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome.
Academic Article	Precision and accuracy of hyperglycemic clamps in a multicenter study.
Academic Article	Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic.
Academic Article	Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity.
Academic Article	Weight Management in Adolescents with Polycystic Ovary Syndrome.
Academic Article	Differential loss of ?-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study.
Academic Article	In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome.
Academic Article	Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity.
Academic Article	11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome.
Academic Article	Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity.
Academic Article	11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity.
Academic Article	Youth-onset type 2 diabetes mellitus: an urgent challenge.
Academic Article	Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study.
Grant	The presentation and medical course of PCOS in adolescents across the United States

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Adolescents