Item Type | Name |
Academic Article
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A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
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Academic Article
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Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
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Academic Article
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Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
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Academic Article
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Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
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Academic Article
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Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
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Academic Article
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Inescapable shock-induced potentiation of morphine analgesia.
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Academic Article
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Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.
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Academic Article
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Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
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Academic Article
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Implications of immune-to-brain communication for sickness and pain.
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Academic Article
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The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
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Academic Article
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The pain of being sick: implications of immune-to-brain communication for understanding pain.
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Academic Article
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Cholecystokinin antianalgesia: safety cues abolish morphine analgesia.
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Academic Article
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Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
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Academic Article
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A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
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Academic Article
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Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
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Academic Article
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Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
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Academic Article
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Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
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Academic Article
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Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing.
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Academic Article
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HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
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Academic Article
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Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
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Academic Article
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Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
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Academic Article
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Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
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Academic Article
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Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.
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Academic Article
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
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Academic Article
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Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
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Academic Article
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Glia: novel counter-regulators of opioid analgesia.
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Academic Article
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Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
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Academic Article
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Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
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Academic Article
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Mediation of chronic pain: not by neurons alone.
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Academic Article
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Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
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Academic Article
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Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
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Academic Article
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A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
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Academic Article
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Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
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Academic Article
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"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
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Academic Article
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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
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Academic Article
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Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
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Academic Article
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Pathological and protective roles of glia in chronic pain.
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Academic Article
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PEGylation of interleukin-10 for the mitigation of enhanced pain states.
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Academic Article
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Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
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Academic Article
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The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
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Academic Article
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Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
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Academic Article
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A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
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Academic Article
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Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
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Academic Article
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Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
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Academic Article
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Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
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Academic Article
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Toll-like receptor 4 in CNS pathologies.
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Academic Article
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Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders.
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Academic Article
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Below level central pain induced by discrete dorsal spinal cord injury.
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Academic Article
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Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
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Academic Article
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Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
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Academic Article
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Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
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Academic Article
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Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
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Academic Article
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Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain.
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Academic Article
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(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats.
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Academic Article
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Understanding chronic inflammatory and neuropathic pain.
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Academic Article
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Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
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Academic Article
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Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
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Academic Article
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Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
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Academic Article
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Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
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Academic Article
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Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
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Academic Article
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Acute and conditioned hyperalgesic responses to illness.
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Academic Article
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Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
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Academic Article
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Neurocircuitry of illness-induced hyperalgesia.
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Academic Article
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Immune regulation of central nervous system functions: from sickness responses to pathological pain.
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Academic Article
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Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences.
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Academic Article
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Central proinflammatory cytokines and pain enhancement.
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Academic Article
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Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
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Academic Article
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A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
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Academic Article
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Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
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Academic Article
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Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats.
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Academic Article
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Glia: a novel drug discovery target for clinical pain.
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Academic Article
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Glial activation and pathological pain.
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Academic Article
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
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Academic Article
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Spinal gap junctions: potential involvement in pain facilitation.
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Academic Article
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Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
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Academic Article
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An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
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Academic Article
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Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
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Academic Article
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Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
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Academic Article
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Chapter 22 Contribution of glia to pain processing in health and disease.
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Academic Article
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Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
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Academic Article
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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
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Academic Article
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Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
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Academic Article
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Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.
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Academic Article
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Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain.
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Academic Article
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The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.
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Academic Article
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Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
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Academic Article
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Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
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Academic Article
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Comment on: excessive opioid use and the development of chronic migraine.
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Academic Article
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Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
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Academic Article
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Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
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Academic Article
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Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
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Academic Article
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An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo.
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Academic Article
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Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages".
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Academic Article
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Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
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Academic Article
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Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
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Academic Article
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Toll-like receptors in chronic pain.
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Academic Article
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Tetracyclines and pain.
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Academic Article
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Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing.
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Academic Article
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Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.
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Concept
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Facial Pain
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Concept
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Pain Measurement
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Concept
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Pain
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Concept
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Pain Threshold
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Concept
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Pain, Intractable
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Concept
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Pain, Postoperative
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Academic Article
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Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
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Academic Article
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Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
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Academic Article
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Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
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Academic Article
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Pathological pain and the neuroimmune interface.
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Academic Article
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Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
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Academic Article
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Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
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Academic Article
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR? mechanisms.
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Academic Article
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Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
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Academic Article
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Prior voluntary wheel running attenuates neuropathic pain.
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Academic Article
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Nitroxidative Signaling Mechanisms in Pathological Pain.
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Academic Article
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Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
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Grant
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PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
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Grant
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ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
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Grant
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Pain facilitation via neuron-to-glia signaling
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Grant
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Pain control via spinal interleukin-10 gene therapy
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Grant
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Immune and Gilia Regulation of Pain & Analgesic Actions
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Grant
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Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
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Grant
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Spinal adenosine modulator: enduring anti-inflammatory action in neuropathic pain
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Grant
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Optoid Analgesics: Modulation of Trigeminal &Spinal Glial Activation
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Grant
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Targeting toll like receptor 4 (TLR4) and TLR2 to resolve EAE-associated paralysis, pain and cognitive deficits: efficacy of a clinically-relevant blood brain barrier permeable TLR4/TLR2 antagonist
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Grant
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Models and mechanisms for the transition of acute-to-chronic orofacial pain
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Grant
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Spinal glia activation in human chronic pain
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Grant
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Targeting neuropathic pain prevention: Modulating the neuroimmunology of peripheral nerve injury
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Grant
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Immune /Glial Mediation of Exaggerated Pain States
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Grant
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Methods Development for Studying Dorsal Spinal Cord Glia
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Grant
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Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions
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Academic Article
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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
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Academic Article
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Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
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Academic Article
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Toll-like receptors and their role in persistent pain.
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Academic Article
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
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Academic Article
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Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
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Academic Article
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Repeated Morphine Prolongs Postoperative Pain in Male Rats.
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Academic Article
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MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
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Grant
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Enduring reversal of chronic pain by adenosine 2a agonism
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Grant
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Enduring enhancement of neuropathic pain by early post-trauma morphine
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Concept
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Chronic Pain
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Concept
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Pain Management
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Academic Article
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Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
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Academic Article
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Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
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Academic Article
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Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
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Academic Article
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Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
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Academic Article
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Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
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Academic Article
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Spatial summation in human thermal pain perception: comparison within and between dermatomes.
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Academic Article
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Comparison of human pain sensation and flexion withdrawal evoked by noxious radiant heat.
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Academic Article
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Autoimmune regulation of chronic pain.
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Academic Article
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Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
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Academic Article
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Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats.
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Academic Article
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Involvement of TLR2-TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis.
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Academic Article
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Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
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Academic Article
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Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
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