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Search Results to Christopher Silliman

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One or more keywords matched the following items that are connected to Silliman, Christopher

Item TypeName
Academic Article Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure.
Academic Article Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release.
Academic Article Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils.
Academic Article Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity.
Academic Article Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines.
Academic Article Hypertonic saline resuscitation abrogates neutrophil priming by mesenteric lymph.
Academic Article Age of transfused blood is an independent risk factor for postinjury multiple organ failure.
Academic Article Secretory phospholipase A2 activity correlates with postinjury multiple organ failure.
Academic Article Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming.
Academic Article Increased rate of infection associated with transfusion of old blood after severe injury.
Academic Article Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1.
Academic Article Transfusion of the injured patient: proceed with caution.
Academic Article The transfusion of pre storage leukoreduced packed red blood cells to injured patients.
Academic Article Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells.
Academic Article HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans.
Academic Article Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma.
Academic Article Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes.
Academic Article Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.
Academic Article Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.
Academic Article It's not your grandfather's field plasma.
Academic Article Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.
Academic Article The injured child is resistant to multiple organ failure: a different inflammatory response?
Academic Article Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
Academic Article Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species.
Academic Article Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation.
Academic Article Secretory phospholipase A2 cleavage of intravasated bone marrow primes human neutrophils.
Academic Article Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure.
Academic Article Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything.
Academic Article Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction.
Academic Article Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.
Academic Article Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Academic Article Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin.
Academic Article The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
Academic Article Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models.
Academic Article Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?
Academic Article Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma.
Academic Article Platelets are dominant contributors to hypercoagulability after injury.
Concept Trauma Centers
Concept Trauma Severity Indices
Concept Multiple Trauma
Concept Wounds and Injuries
Academic Article The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal.
Academic Article The authors reply.
Academic Article Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy.
Academic Article Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients.
Academic Article Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.
Academic Article Plasma first in the field for postinjury hemorrhagic shock.
Academic Article Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.
Academic Article Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.
Academic Article Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients.
Academic Article Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy.
Academic Article Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury.
Academic Article Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.
Academic Article Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.
Academic Article Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early.
Academic Article Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock.
Academic Article Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.
Academic Article Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.
Academic Article Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation.
Academic Article The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis.
Academic Article Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
Academic Article Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.
Academic Article Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.
Academic Article Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.
Academic Article Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.
Academic Article Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research.
Academic Article Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion.
Academic Article Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes.
Academic Article Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy.
Academic Article Plasma succinate is a predictor of mortality in critically injured patients.
Academic Article Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.
Academic Article Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.
Academic Article Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion.
Academic Article Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis.
Academic Article 14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.
Academic Article All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
Academic Article Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
Academic Article Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.
Academic Article Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium.
Academic Article Empiric transfusion strategies during life-threatening hemorrhage.
Academic Article Rotational thromboelastometry thresholds for patients at risk for massive transfusion.
Academic Article Rapid TEG efficiently guides hemostatic resuscitation in trauma patients.
Academic Article Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
Academic Article Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial.
Academic Article Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion.
Academic Article Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays.
Academic Article Severe traumatic brain injury is associated with a unique coagulopathy phenotype.
Academic Article Trauma Resuscitation Consideration: Sex Matters.
Academic Article Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy.
Academic Article Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits.
Academic Article Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy.
Grant Resuscitation Strategies for Achieving Thrombo-inflammatory Homeostasis
Academic Article Obesity is associated with postinjury hypercoagulability.
Academic Article Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.
Academic Article Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects.
Academic Article Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation.
Academic Article Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients.
Academic Article Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy.
Academic Article Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion.
Academic Article The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro.

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