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Search Results to Christopher Silliman

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Silliman, Christopher

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Item Type	Name
Academic Article	Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure.
Academic Article	The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study.
Academic Article	Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.
Academic Article	Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils.
Academic Article	Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines.
Academic Article	Posthemorrhagic shock mesenteric lymph primes circulating neutrophils and provokes lung injury.
Academic Article	Age of transfused blood is an independent risk factor for postinjury multiple organ failure.
Academic Article	Blood transfusion and the two-insult model of post-injury multiple organ failure.
Academic Article	Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming.
Academic Article	Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1.
Academic Article	The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury.
Academic Article	Transfusion of the injured patient: proceed with caution.
Academic Article	Transfusion-related acute lung injury: definition and review.
Academic Article	Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury.
Academic Article	The two-event model of transfusion-related acute lung injury.
Academic Article	The transfusion of pre storage leukoreduced packed red blood cells to injured patients.
Academic Article	Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells.
Academic Article	Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill.
Academic Article	HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans.
Academic Article	Transfusion-related acute lung injury (TRALI): current concepts and misconceptions.
Academic Article	Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components.
Academic Article	Transfusion-related acute lung injury.
Academic Article	Female donors and transfusion-related acute lung injury: A case-referent study from the International TRALI Unisex Research Group.
Academic Article	Transfusion-related acute lung injury and granulocytes from stored packed RBCs.
Academic Article	Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury.
Academic Article	Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma.
Academic Article	Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes.
Academic Article	The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance.
Academic Article	Measures to prevent transfusion-related acute lung injury (TRALI).
Academic Article	Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor.
Academic Article	Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.
Academic Article	Isoflurane prevents acute lung injury?through ADP-mediated platelet inhibition.
Academic Article	Broken hearts and transfusion-related acute lung injury.
Academic Article	It's not your grandfather's field plasma.
Academic Article	Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.
Academic Article	Hyperosmolarity attenuates TNF-a-mediated proinflammatory activation of human pulmonary microvascular endothelial cells.
Academic Article	The injured child is resistant to multiple organ failure: a different inflammatory response?
Academic Article	Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
Academic Article	Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species.
Academic Article	Transfusion-related acute lung injury.
Academic Article	Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure.
Academic Article	Transfusion-related acute lung injury secondary to biologically active mediators.
Academic Article	Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.
Academic Article	Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Academic Article	Plasma and lipids from stored platelets cause acute lung injury in an animal model.
Academic Article	Transfusion-related acute lung injury.
Academic Article	The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury.
Academic Article	Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model.
Academic Article	The role of neutrophils in the pathogenesis of transfusion-related acute lung injury.
Academic Article	Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding.
Academic Article	A novel in vivo ovine model of transfusion-related acute lung injury (TRALI).
Academic Article	Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation.
Academic Article	Cross-transfusion of postshock mesenteric lymph provokes acute lung injury.
Academic Article	The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
Academic Article	Proteomic analyses of human plasma: Venus versus Mars.
Academic Article	Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis.
Academic Article	Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models.
Academic Article	Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI).
Academic Article	Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?
Academic Article	Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma.
Academic Article	Platelets are dominant contributors to hypercoagulability after injury.
Concept	Abdominal Injuries
Concept	Brain Injuries
Concept	Blast Injuries
Concept	Lung Injury
Concept	Reperfusion Injury
Concept	Acute Lung Injury
Concept	Injury Severity Score
Concept	Wounds and Injuries
Academic Article	The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal.
Academic Article	The authors reply.
Academic Article	Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy.
Academic Article	Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients.
Academic Article	Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.
Academic Article	Plasma first in the field for postinjury hemorrhagic shock.
Academic Article	Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.
Academic Article	Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo.
Academic Article	Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury.
Academic Article	Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.
Academic Article	Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients.
Academic Article	Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy.
Academic Article	Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury.
Academic Article	Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.
Academic Article	Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.
Academic Article	Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early.
Academic Article	Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock.
Academic Article	A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE.
Academic Article	a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2.
Academic Article	Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.
Academic Article	Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.
Academic Article	The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis.
Academic Article	Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
Academic Article	Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.
Academic Article	Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.
Academic Article	Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion.
Academic Article	LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils.
Academic Article	Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model.
Academic Article	Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury.
Academic Article	The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration.
Grant	Lyso-PCs activate PMNs and endothelium via PKC
Academic Article	Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes.
Academic Article	Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy.
Academic Article	Plasma succinate is a predictor of mortality in critically injured patients.
Academic Article	Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.
Academic Article	Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation.
Academic Article	Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.
Academic Article	Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion.
Academic Article	Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis.
Academic Article	14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.
Academic Article	All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
Academic Article	Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
Academic Article	The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model.
Academic Article	PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets.
Academic Article	Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.
Academic Article	Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium.
Academic Article	Empiric transfusion strategies during life-threatening hemorrhage.
Academic Article	Rotational thromboelastometry thresholds for patients at risk for massive transfusion.
Academic Article	Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
Academic Article	Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion.
Academic Article	Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays.
Academic Article	Severe traumatic brain injury is associated with a unique coagulopathy phenotype.
Academic Article	Trauma Resuscitation Consideration: Sex Matters.
Academic Article	Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.
Concept	Transfusion-Related Acute Lung Injury
Concept	Brain Injuries, Traumatic
Concept	Crush Injuries
Concept	Acute Kidney Injury
Academic Article	A consensus redefinition of transfusion-related acute lung injury.
Academic Article	Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy.
Academic Article	Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits.
Academic Article	Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy.
Academic Article	An update of the transfusion-related acute lung injury (TRALI) definition.
Academic Article	Obesity is associated with postinjury hypercoagulability.
Academic Article	Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update.
Academic Article	Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.
Academic Article	Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects.
Academic Article	Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation.
Academic Article	Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation.
Academic Article	Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients.
Academic Article	Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy.
Academic Article	Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion.
Academic Article	The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro.
Academic Article	A combat casualty relevant dismounted complex blast injury model in swine.
Academic Article	Zone 1 REBOA in a combat DCBI swine model does not worsen brain?injury.
Academic Article	SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE.
Academic Article	Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model.
Academic Article	BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY.
Academic Article	Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor.
Academic Article	OUTCOMES FOLLOWING ZONE 3 AND ZONE 1 AORTIC OCCLUSION FOR THE TREATMENT OF BLUNT PELVIC INJURIES.
Academic Article	A proposed clinical coagulation score for research in trauma-induced coagulopathy.
Academic Article	Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine.
Academic Article	A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation.
Academic Article	The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury.
Academic Article	Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.

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