Item Type | Name |
Academic Article
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Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure.
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Academic Article
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The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study.
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Academic Article
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Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.
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Academic Article
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Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils.
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Academic Article
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Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines.
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Academic Article
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Posthemorrhagic shock mesenteric lymph primes circulating neutrophils and provokes lung injury.
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Academic Article
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Age of transfused blood is an independent risk factor for postinjury multiple organ failure.
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Academic Article
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Blood transfusion and the two-insult model of post-injury multiple organ failure.
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Academic Article
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Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming.
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Academic Article
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Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1.
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Academic Article
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The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury.
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Academic Article
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Transfusion of the injured patient: proceed with caution.
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Academic Article
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Transfusion-related acute lung injury: definition and review.
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Academic Article
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Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury.
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Academic Article
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The two-event model of transfusion-related acute lung injury.
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Academic Article
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The transfusion of pre storage leukoreduced packed red blood cells to injured patients.
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Academic Article
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Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells.
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Academic Article
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Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill.
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Academic Article
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HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans.
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Academic Article
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Transfusion-related acute lung injury (TRALI): current concepts and misconceptions.
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Academic Article
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Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components.
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Academic Article
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Transfusion-related acute lung injury.
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Academic Article
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Female donors and transfusion-related acute lung injury: A case-referent study from the International TRALI Unisex Research Group.
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Academic Article
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Transfusion-related acute lung injury and granulocytes from stored packed RBCs.
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Academic Article
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Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury.
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Academic Article
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Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma.
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Academic Article
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Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes.
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Academic Article
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The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance.
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Academic Article
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Measures to prevent transfusion-related acute lung injury (TRALI).
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Academic Article
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Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor.
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Academic Article
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Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.
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Academic Article
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Isoflurane prevents acute lung injury?through ADP-mediated platelet inhibition.
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Academic Article
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Broken hearts and transfusion-related acute lung injury.
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Academic Article
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It's not your grandfather's field plasma.
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Academic Article
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Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.
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Academic Article
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Hyperosmolarity attenuates TNF-a-mediated proinflammatory activation of human pulmonary microvascular endothelial cells.
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Academic Article
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The injured child is resistant to multiple organ failure: a different inflammatory response?
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Academic Article
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Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
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Academic Article
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Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species.
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Academic Article
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Transfusion-related acute lung injury.
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Academic Article
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Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure.
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Academic Article
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Transfusion-related acute lung injury secondary to biologically active mediators.
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Academic Article
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Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.
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Academic Article
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Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
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Academic Article
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Plasma and lipids from stored platelets cause acute lung injury in an animal model.
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Academic Article
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Transfusion-related acute lung injury.
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Academic Article
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The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury.
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Academic Article
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Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model.
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Academic Article
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The role of neutrophils in the pathogenesis of transfusion-related acute lung injury.
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Academic Article
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Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding.
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Academic Article
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A novel in vivo ovine model of transfusion-related acute lung injury (TRALI).
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Academic Article
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Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation.
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Academic Article
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Cross-transfusion of postshock mesenteric lymph provokes acute lung injury.
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Academic Article
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The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
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Academic Article
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Proteomic analyses of human plasma: Venus versus Mars.
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Academic Article
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Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis.
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Academic Article
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Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models.
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Academic Article
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Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI).
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Academic Article
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Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?
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Academic Article
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Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma.
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Academic Article
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Platelets are dominant contributors to hypercoagulability after injury.
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Concept
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Abdominal Injuries
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Concept
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Brain Injuries
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Concept
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Blast Injuries
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Concept
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Lung Injury
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Concept
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Reperfusion Injury
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Concept
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Acute Lung Injury
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Concept
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Injury Severity Score
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Concept
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Wounds and Injuries
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Academic Article
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The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal.
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Academic Article
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The authors reply.
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Academic Article
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Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy.
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Academic Article
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Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients.
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Academic Article
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Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.
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Academic Article
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Plasma first in the field for postinjury hemorrhagic shock.
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Academic Article
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Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.
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Academic Article
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Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo.
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Academic Article
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Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury.
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Academic Article
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Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.
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Academic Article
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Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients.
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Academic Article
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Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy.
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Academic Article
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Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury.
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Academic Article
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Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.
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Academic Article
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Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.
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Academic Article
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Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early.
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Academic Article
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Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock.
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Academic Article
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A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE.
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Academic Article
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a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2.
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Academic Article
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Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.
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Academic Article
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Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.
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Academic Article
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The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis.
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Academic Article
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Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
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Academic Article
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Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.
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Academic Article
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Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.
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Academic Article
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Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion.
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Academic Article
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LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils.
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Academic Article
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Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model.
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Academic Article
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Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury.
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Academic Article
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The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration.
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Grant
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Lyso-PCs activate PMNs and endothelium via PKC
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Academic Article
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Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes.
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Academic Article
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Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy.
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Academic Article
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Plasma succinate is a predictor of mortality in critically injured patients.
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Academic Article
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Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.
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Academic Article
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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation.
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Academic Article
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Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.
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Academic Article
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Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion.
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Academic Article
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Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis.
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Academic Article
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14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.
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Academic Article
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All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
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Academic Article
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Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
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Academic Article
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The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model.
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Academic Article
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PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets.
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Academic Article
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Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.
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Academic Article
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Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium.
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Academic Article
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Empiric transfusion strategies during life-threatening hemorrhage.
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Academic Article
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Rotational thromboelastometry thresholds for patients at risk for massive transfusion.
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Academic Article
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Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
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Academic Article
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Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion.
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Academic Article
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Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays.
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Academic Article
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Severe traumatic brain injury is associated with a unique coagulopathy phenotype.
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Academic Article
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Trauma Resuscitation Consideration: Sex Matters.
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Academic Article
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Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.
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Concept
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Transfusion-Related Acute Lung Injury
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Concept
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Brain Injuries, Traumatic
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Concept
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Crush Injuries
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Concept
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Acute Kidney Injury
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Academic Article
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A consensus redefinition of transfusion-related acute lung injury.
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Academic Article
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Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy.
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Academic Article
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Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits.
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Academic Article
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Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy.
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Academic Article
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An update of the transfusion-related acute lung injury (TRALI) definition.
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Academic Article
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Obesity is associated with postinjury hypercoagulability.
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Academic Article
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Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update.
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Academic Article
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Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.
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Academic Article
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Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects.
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Academic Article
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Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation.
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Academic Article
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Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation.
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Academic Article
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Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients.
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Academic Article
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Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy.
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Academic Article
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Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion.
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Academic Article
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The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro.
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Academic Article
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A combat casualty relevant dismounted complex blast injury model in swine.
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Academic Article
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Zone 1 REBOA in a combat DCBI swine model does not worsen brain?injury.
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Academic Article
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SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE.
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Academic Article
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Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model.
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Academic Article
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BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY.
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Academic Article
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Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor.
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Academic Article
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OUTCOMES FOLLOWING ZONE 3 AND ZONE 1 AORTIC OCCLUSION FOR THE TREATMENT OF BLUNT PELVIC INJURIES.
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Academic Article
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A proposed clinical coagulation score for research in trauma-induced coagulopathy.
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Academic Article
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Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine.
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Academic Article
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A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation.
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Academic Article
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The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury.
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Academic Article
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Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.
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