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Search Results to Lorna Grindlay Moore

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overview My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

One or more keywords matched the following items that are connected to Moore, Lorna

Item TypeName
Academic Article Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women.
Academic Article Hypoxic responses in infants. No known mechanism links hypoxia and sudden infant death syndrome.
Academic Article Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m.
Academic Article Human adaptation to high altitude: regional and life-cycle perspectives.
Academic Article Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle.
Academic Article Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado.
Academic Article Women at altitude: carbohydrate utilization during exercise at 4,300 m.
Academic Article Comparative aspects of high-altitude adaptation in human populations.
Academic Article Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries.
Academic Article Altitude and fetal growth: current knowledge and future directions.
Academic Article Intraocular pressure and acclimatization to 4300 M altitude.
Academic Article Oxygen transport in tibetan women during pregnancy at 3,658 m.
Academic Article Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade.
Academic Article Human genetic adaptation to high altitude.
Academic Article Circulatory responses to orthostasis during alpha1-adrenergic receptor blockade at high altitude.
Academic Article Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase.
Academic Article Analysis of the myoglobin gene in Tibetans living at high altitude.
Academic Article Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow.
Academic Article Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia.
Academic Article Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
Academic Article Influence of alpha-adrenergic blockade on the catecholamine response to exercise at 4,300 meters.
Academic Article Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review.
Academic Article Consensus statement on chronic and subacute high altitude diseases.
Academic Article Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro.
Academic Article Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents.
Academic Article Does chronic mountain sickness (CMS) have perinatal origins?
Academic Article Evidence that parent-of-origin affects birth-weight reductions at high altitude.
Academic Article Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.
Academic Article Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth.
Academic Article Evolutionary adaptation to high altitude: a view from in utero.
Academic Article Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.
Academic Article Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?
Academic Article Comparative human ventilatory adaptation to high altitude.
Academic Article Humans at high altitude: hypoxia and fetal growth.
Academic Article Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight.
Academic Article Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude.
Academic Article Women at altitude: ventilatory acclimatization at 4,300 m.
Academic Article Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.
Academic Article Role of cytokines in altitude-associated preeclampsia.
Academic Article Speech motor control and acute mountain sickness.
Academic Article Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians.
Academic Article Andean and Tibetan patterns of adaptation to high altitude.
Academic Article High altitude residence during pregnancy alters cytokine and catecholamine levels.
Academic Article Human physiological adaptation to pregnancy: inter- and intraspecific perspectives.
Academic Article The quest for riches, or how mining silver in Bolivia has enriched our knowledge of the mechanisms underlying reproductive success.
Academic Article Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m.
Academic Article ECG observations in Tibetan and Han residents of Lhasa.
Academic Article Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation.
Academic Article Women at altitude: energy requirement at 4,300 m.
Academic Article Catecholamine responses to alpha-adrenergic blockade during exercise in women acutely exposed to altitude.
Academic Article Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity.
Academic Article Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping.
Academic Article Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade.
Academic Article High-altitude ancestry protects against hypoxia-associated reductions in fetal growth.
Academic Article Medical recommendations for women going to altitude.
Academic Article Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude.
Academic Article An evolutionary model for identifying genetic adaptation to high altitude.
Academic Article Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?
Academic Article Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.
Academic Article High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.
Academic Article Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis).
Academic Article Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation.
Academic Article Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans.
Concept Altitude
Concept Altitude Sickness
Concept Severity of Illness Index
Academic Article Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity.
Academic Article Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.
Academic Article Graduated effects of high-altitude hypoxia and highland ancestry on birth size.
Academic Article Uterine artery blood flow, fetal hypoxia and fetal growth.
Academic Article Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitude (2013 Grover Conference series).
Academic Article Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction.
Academic Article Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy.
Academic Article Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2a) polymorphism lowers hemoglobin concentration in Tibetan highlanders.
Grant Genetic Regulation of Hypoxia-Induced IUGR
Grant Chronic hypoxia, AMPK activation and uterine artery blood flow
Grant Perinatal Origins of Chronic Mountain Sickness
Academic Article Maternal O2 transport and fetal growth in Colorado, Peru, and Tibet high-altitude residents.
Academic Article Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level.
Academic Article High altitude and hypertension during pregnancy.
Academic Article Measuring high-altitude adaptation.
Grant Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia
Academic Article Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.
Academic Article Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.
Academic Article Gestational Diabetes Prevalence at Moderate and High Altitude.
Academic Article Human Genetic Adaptation to High Altitude: Evidence from the Andes.
Academic Article High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy.
Academic Article Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction.
Academic Article High Altitude Continues to Reduce Birth Weights in Colorado.
Academic Article Effect of high altitude on human placental amino acid transport.
Academic Article Uteroplacental Ischemia Is Associated with Increased PAPP-A2.
Academic Article Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy.
Academic Article High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy.
Academic Article AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies.
Academic Article HYPOXIA AND REPRODUCTIVE HEALTH: Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being.
Academic Article High altitude regulates the expression of AMPK pathways in human placenta.

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