Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.


Search Results to Lorna Grindlay Moore

This is a "connection" page, showing the details of why an item matched the keywords from your search.


One or more keywords matched the following properties of Moore, Lorna

overview My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

One or more keywords matched the following items that are connected to Moore, Lorna

Item TypeName
Academic Article Chronic hypoxia diminishes pregnancy-associated DNA synthesis in guinea pig uteroplacental arteries.
Academic Article Oxygen transport in tibetan women during pregnancy at 3,658 m.
Academic Article Human genetic adaptation to high altitude.
Academic Article Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia.
Academic Article Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
Academic Article Evidence that parent-of-origin affects birth-weight reductions at high altitude.
Academic Article Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.
Academic Article Evolutionary adaptation to high altitude: a view from in utero.
Academic Article Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?
Academic Article Comparative human ventilatory adaptation to high altitude.
Academic Article Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude.
Academic Article Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.
Academic Article Human physiological adaptation to pregnancy: inter- and intraspecific perspectives.
Academic Article High-altitude ancestry protects against hypoxia-associated reductions in fetal growth.
Academic Article Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude.
Academic Article An evolutionary model for identifying genetic adaptation to high altitude.
Academic Article Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?
Academic Article High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.
Concept Fetal Growth Retardation
Academic Article Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth.
Grant Chronic hypoxia, AMPK activation and uterine artery blood flow
Grant Perinatal Origins of Chronic Mountain Sickness
Academic Article Maternal uterine vascular remodeling during pregnancy.
Grant Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia
Academic Article Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction.
Academic Article Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction?.
Academic Article Effect of high altitude on human placental amino acid transport.
Academic Article Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy.
Academic Article AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies.
Academic Article AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.
Academic Article Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Academic Article Is Maternal Cardiovascular Performance Impaired in Altitude-Associated Fetal Growth Restriction?
Academic Article Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.

Search Criteria
  • Intrauterine Growth Restriction

Copyright © 2023 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)