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Search Results to Stephanie R. Wesolowski

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Wesolowski, Stephanie

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My long-term goal is to understand how altered nutrient supply programs fetal metabolism and how these changes may persist after birth and increase susceptibility to adult metabolic disease. My primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. This is important in understanding why IUGR offspring have increased susceptibility to diabetes across their lifespan. I am also involved in projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of non-alcoholic fatty liver disease (NAFLD) and immune cell reprogramming. Current Projects in the lab with cellular metabolism, molecular biology, metabolic flux, and in vivo fetal physiology include: • Molecular mechanisms for early development of fetal hepatic insulin resistance on suppression of glucose production in fetuses with IUGR • Coordination of carbon and energy substrates (metabolic flux) within the liver and from other fetal organs and the placenta to support early activation of hepatic glucose production in IUGR fetus • Role of hypoxia versus hypoglycemia in the early activation of fetal hepatic glucose production • Effect of intrauterine exposures on fetal hepatic immune cell programming and function • Mechanisms for early development of steatosis and NAFLD risk following exposure to maternal obesity • Intrauterine intervention strategies to prevent later life metabolic disease risk

One or more keywords matched the following items that are connected to Wesolowski, Stephanie

Item Type	Name
Concept	Hypoxia
Concept	Fetal Hypoxia
Academic Article	Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.
Academic Article	Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
Grant	Chronic hypoxia, AMPK activation and uterine artery blood flow
Grant	Effect of hypoxia on glucose metabolism in IUGR fetal liver
Grant	Nutrient and Insulin Metabolic Actions in IUGR Fetal Liver
Academic Article	Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.
Grant	Glucose metabolism in the fetal liver during hypoxia
Academic Article	Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.
Academic Article	Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.
Academic Article	Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep.
Academic Article	Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.

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Hypoxia