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Search Results to Robert Corwine Roach Jr.

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Roach Jr., Robert

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My research focuses on the broad area of human responses to hypoxia. Current research is focused on three major areas: cerebrovascular hemodynamics in hypoxia and exercise; transcriptomic prediction of human responses to hypoxia; and the integration of systems biology with integrative, whole body physiology to understand the molecular and cellular mechanisms of oxygen sensing in humans. Cerebrovascular Hemodynamics: We have recently shown that hypoxia impairs cerebral autoregulation; research is underway to begin to understand the importance of this finding and its possible mechanisms. Prediction of Human Responses to Hypoxia: We found that a gene expression signature from a blood sample collected in Denver predicted >95% of those who later developed acute mountain sickness. A recent validation study at lower altitudes in a more diverse population confirmed these findings. Studies are underway to examine the physiological links of these transcriptomic markers and pathways that lead to susceptibility to altitude illness. Systems biology and human integrative physiological responses to hypoxia: We are undertaking studies to link a comprehensive ‘omics’ pathway of oxygen sensing (transcriptomics, epigenetics, proteomics, metabolomics) to physiological responses that serve to improve oxygen transport during acute and chronic hypoxia. At the Altitude Research Center I have mentored 17 junior researchers, ranging from research fellows in Emergency Medicine, Neurology and Pulmonary Medicine to medical students, postdoctoral fellows and undergraduate students. I am active on the Department of Emergency Medicine research council, and mentor an additional six junior faculty on hypoxia research-related topics.

One or more keywords matched the following items that are connected to Roach Jr., Robert

Item Type	Name
Academic Article	Acute mountain sickness and acetazolamide. Clinical efficacy and effect on ventilation.
Academic Article	Clove cigarettes and high-altitude pulmonary edema.
Academic Article	Body fluid alterations during head-down bed rest in men at moderate altitude.
Academic Article	Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria.
Academic Article	Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia.
Academic Article	Hypoxia and the cardiovascular response to dynamic knee-extensor exercise.
Academic Article	Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans.
Academic Article	Effects of prolonged head-down bed rest on physiological responses to moderate hypoxia.
Academic Article	Effects of acid-base status on acute hypoxic pulmonary vasoconstriction and gas exchange.
Academic Article	Frontiers of hypoxia research: acute mountain sickness.
Academic Article	Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men.
Academic Article	The influence of PaO2, pH and SaO2 on maximal oxygen uptake.
Academic Article	Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema.
Academic Article	Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise.
Academic Article	Operation Everest II: ventilatory adaptation during gradual decompression to extreme altitude.
Academic Article	Hypoxemia and acute mountain sickness: which comes first?
Academic Article	Genomic analysis of high altitude adaptation: innovations and implications.
Academic Article	Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same.
Academic Article	Does cerebral oxygen delivery limit incremental exercise performance?
Academic Article	Dexamethasone for prevention and treatment of acute mountain sickness.
Academic Article	High-altitude pulmonary edema. Characteristics of lung lavage fluid.
Academic Article	Abnormal control of ventilation in high-altitude pulmonary edema.
Academic Article	Acute mountain sickness, antacids, and ventilation during rapid, active ascent of Mount Rainier.
Academic Article	Acute ventilatory response to simulated altitude, normobaric hypoxia, and hypobaria.
Academic Article	Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives.
Academic Article	Role of hypobaria in fluid balance response to hypoxia.
Academic Article	Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia.
Academic Article	Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m.
Academic Article	Acute hypoxia impairs dynamic cerebral autoregulation: results from two independent techniques.
Academic Article	Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance.
Academic Article	Pulmonary edema induced by cerebral hypoxic insult in a canine model.
Academic Article	Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation.
Academic Article	Effects of hypobaric hypoxia on cerebral autoregulation.
Academic Article	Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia.
Academic Article	The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema.
Academic Article	Medical therapy of altitude illness.
Academic Article	High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure.
Concept	Hypoxia, Brain
Concept	Hypoxia
Concept	Hypoxia-Inducible Factor 1, alpha Subunit

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Hypoxia