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Search Results to Kurt R Stenmark

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Stenmark, Kurt

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Item Type	Name
Academic Article	Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.
Academic Article	Hypoxia selectively induces proliferation in a specific subpopulation of smooth muscle cells in the bovine neonatal pulmonary arterial media.
Academic Article	Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension.
Academic Article	Diethylcarbamazine inhibits acute and chronic hypoxic pulmonary hypertension in awake rats.
Academic Article	Progressive loss of vasodilator responsive component of pulmonary hypertension in neonatal calves exposed to 4,570 m.
Academic Article	Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries.
Academic Article	Leukotriene C4 and D4 in neonates with hypoxemia and pulmonary hypertension.
Academic Article	Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension.
Academic Article	Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension.
Academic Article	Hypoxia stimulates proliferation of a unique cell population isolated from the bovine vascular media.
Academic Article	Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities.
Academic Article	Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung.
Academic Article	Hypoxic growth of bovine pulmonary artery smooth muscle cells: dependence on synergy, heterogeneity, and injury-induced phenotypic change.
Academic Article	Hypoxia induces cell-specific changes in gene expression in vascular wall cells: implications for pulmonary hypertension.
Academic Article	Myocyte cytoskeletal disorganization and right heart failure in hypoxia-induced neonatal pulmonary hypertension.
Academic Article	Unique growth properties of neonatal pulmonary vascular cells: importance of time- and site-specific responses, cell-cell interaction, and synergy.
Academic Article	Hypoxia-induced pulmonary vascular remodeling: contribution of the adventitial fibroblasts.
Academic Article	Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases.
Academic Article	Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties.
Academic Article	Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells.
Academic Article	Bromodeoxyuridine labeling and DNA content of pulmonary arterial medial cells from hypoxia-exposed and nonexposed healthy calves.
Academic Article	Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells.
Academic Article	Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.
Academic Article	Lung endothelial cell proliferation in normal and pulmonary hypertensive neonatal calves.
Academic Article	Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression.
Academic Article	Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.
Academic Article	Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
Academic Article	Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension.
Academic Article	Hypoxia, leukocytes, and the pulmonary circulation.
Academic Article	Neonatal calves develop airflow limitation due to chronic hypobaric hypoxia.
Academic Article	Determination of transforming growth factor-beta mRNA levels in pulmonary arteries from normal and hypoxic calves.
Academic Article	Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
Academic Article	Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation.
Academic Article	Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling.
Academic Article	Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.
Academic Article	Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1.
Academic Article	Role of the adventitia in pulmonary vascular remodeling.
Academic Article	Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
Academic Article	Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling.
Academic Article	Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.
Academic Article	Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.
Academic Article	Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
Academic Article	Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension.
Academic Article	Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration.
Academic Article	Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.
Academic Article	Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Academic Article	Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia.
Academic Article	Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGF? receptor-JNK1 signalling.
Academic Article	Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Academic Article	MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
Academic Article	Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension.
Academic Article	Leukotriene C4 production during hypoxic pulmonary vasoconstriction in isolated rat lungs.
Academic Article	Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
Academic Article	Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C.
Academic Article	Distensibility of the normal human lung circulation during exercise.
Academic Article	Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia.
Academic Article	Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes.
Academic Article	Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia.
Academic Article	Pulmonary vascular impedance and wave reflections in the hypoxic calf.
Academic Article	Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Academic Article	Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase.
Academic Article	Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.
Academic Article	Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal?
Academic Article	Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling.
Academic Article	Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.
Academic Article	Alpha-skeletal actin messenger RNA increases in acute right ventricular hypertrophy.
Academic Article	PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.
Academic Article	Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia.
Academic Article	Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
Academic Article	Leukotrienes and prostaglandins in fetal lung liquid.
Academic Article	Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves.
Academic Article	Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells.
Academic Article	Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
Academic Article	Response of lobar vessels to hypoxic pulmonary hypertension.
Academic Article	Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m.
Academic Article	Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.
Academic Article	Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Academic Article	Vascular remodeling in neonatal pulmonary hypertension. Role of the smooth muscle cell.
Academic Article	[Inhibition of hypoxic pulmonary vasoconstriction by leukotriene blockade].
Concept	Hypoxia
Concept	Hypoxia-Inducible Factor 1
Concept	Hypoxia-Inducible Factor 1, alpha Subunit
Concept	Cell Hypoxia
Academic Article	High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization.
Academic Article	Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
Academic Article	Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.
Academic Article	Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.
Academic Article	Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction.
Academic Article	The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.
Academic Article	Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.
Academic Article	The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.
Academic Article	Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension.
Academic Article	Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.
Academic Article	Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.
Grant	Crosstalk Between Metabolism and Inflammation in Pulmonary Hypertension
Grant	Adaptation to Hypoxia
Grant	LUNG LIPIDS IN NEONATAL PULMONARY HYPERTENSIVE DISEASES
Academic Article	A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.
Academic Article	TGF-? activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.
Academic Article	Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.
Academic Article	Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.
Academic Article	Hypoxia-induced pulmonary hypertension and chronic lung disease: caveolin-1 dysfunction an important underlying feature.
Concept	Hypoxia-Inducible Factor-Proline Dioxygenases
Academic Article	An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.
Academic Article	Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.
Academic Article	Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
Academic Article	Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.
Academic Article	Pluripotent hematopoietic stem cells augment a-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Academic Article	Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
Academic Article	Platelet activation contributes to hypoxia-induced inflammation.
Academic Article	Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects.
Academic Article	Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.
Academic Article	The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension.
Academic Article	Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia.
Academic Article	Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia.
Academic Article	HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury.
Academic Article	The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.
Academic Article	Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model.
Academic Article	Pericytes contribute to pulmonary vascular remodeling via HIF2a signaling.

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