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Search Results to Mamuka Kvaratskhelia

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Kvaratskhelia, Mamuka

One or more keywords matched the following items that are connected to Kvaratskhelia, Mamuka

Item Type	Name
Concept	HIV Seropositivity
Concept	HIV Integrase
Concept	gag Gene Products, Human Immunodeficiency Virus
Concept	HIV Integrase Inhibitors
Concept	HIV-1
Concept	HIV Reverse Transcriptase
Concept	Ribonuclease H, Human Immunodeficiency Virus
Concept	HIV Infections
Concept	Anti-HIV Agents
Academic Article	A new class of multimerization selective inhibitors of HIV-1 integrase.
Academic Article	TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.
Academic Article	The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Academic Article	LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.
Academic Article	Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase.
Academic Article	HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
Academic Article	Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins.
Academic Article	Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells.
Academic Article	Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.
Academic Article	Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.
Academic Article	The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Academic Article	Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch.
Academic Article	Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.
Academic Article	HIV-1 Integrase-DNA Recognition Mechanisms.
Academic Article	Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase.
Academic Article	The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article	Allosteric inhibition of HIV-1 integrase activity.
Academic Article	Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.
Academic Article	Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article	Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.
Academic Article	Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.
Academic Article	HIV-1 integrase multimerization as a therapeutic target.
Academic Article	A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
Academic Article	Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Academic Article	Molecular mechanisms of retroviral integration site selection.
Academic Article	Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Academic Article	Interactions of HIV-1 Gag with assembly cofactors.
Academic Article	Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.
Academic Article	A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Academic Article	Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.
Academic Article	FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.
Academic Article	Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.
Academic Article	Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.
Academic Article	An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.
Academic Article	HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Academic Article	Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.
Academic Article	Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.
Academic Article	Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.
Grant	HIV-1 Gag structure as a therapeutic target
Grant	Multimeric HIV-1 Integrase Inhibitors
Grant	Cellular Cofactors of Murine Leukemia Virus Integrase
Grant	Structure and function of HIV-1 integrase
Grant	Novel Assay for HIV-1 Integrase Inhibitors
Grant	HIV-1 Integrase Structure and Function as a Therapeutic Target
Academic Article	N6-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production.
Academic Article	HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
Academic Article	Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Academic Article	Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Academic Article	An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Academic Article	HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1.
Grant	Multimeric HIV-1 Integrase Inhibitors
Academic Article	HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Academic Article	Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.
Academic Article	Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.
Academic Article	Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Grant	Ultra-potent HIV capsid inhibitors
Academic Article	Sec24C is an HIV-1 host dependency factor crucial for virus replication.
Academic Article	A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
Academic Article	HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.
Academic Article	Identification and Optimization of a Novel HIV-1 Integrase Inhibitor.
Academic Article	Multimodal Functionalities of HIV-1 Integrase.
Academic Article	Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Academic Article	Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Academic Article	The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Academic Article	Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.
Academic Article	HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA.
Academic Article	Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.

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