The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction.
Squires S, Katte JC, Dabelea D, Pihoker C, Divers J, Sobngwi E, Nyirenda MJ, Kreienkamp RJ, Liese AD, Shah AS, Dolan L, Reynolds K, Redondo MJ, Hagopian W, Fatumo S, Dehayem MY, Hattersley A, Weedon MN, Jones A, Oram RA. The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction. medRxiv. 2025 Jul 17.