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Connection

Ram Nagaraj to Lens, Crystalline

This is a "connection" page, showing publications Ram Nagaraj has written about Lens, Crystalline.

 
Connection Strength
  
 
 
13.465
  
  1. Panja S, Nahomi RB, Rankenberg J, Michel CR, Gaikwad H, Nam MH, Nagaraj RH. Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia. Aging Cell. 2023 04; 22(4):e13797.
    View in: PubMed
    Score: 0.770
  2. Panja S, Gaikwad H, Rankenberg J, Nam MH, Nagaraj RH. Promotion of Protein Solubility and Reduction in Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. Int J Mol Sci. 2023 Jan 22; 24(3).
    View in: PubMed
    Score: 0.765
  3. Nam MH, Pantcheva MB, Rankenberg J, Nagaraj RH. Transforming growth factor-?2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE. Biochem J. 2021 06 25; 478(12):2285-2296.
    View in: PubMed
    Score: 0.686
  4. Nandi SK, Rankenberg J, Rakete S, Nahomi RB, Glomb MA, Linetsky MD, Nagaraj RH. Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro. Glycoconj J. 2021 06; 38(3):347-359.
    View in: PubMed
    Score: 0.659
  5. Nandi SK, Nahomi RB, Rankenberg J, Glomb MA, Nagaraj RH. Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of a-crystallin: Implications for lens aging and presbyopia. J Biol Chem. 2020 04 24; 295(17):5701-5716.
    View in: PubMed
    Score: 0.628
  6. Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH. Lysine malonylation and propionylation are prevalent in human lens proteins. Exp Eye Res. 2020 01; 190:107864.
    View in: PubMed
    Score: 0.612
  7. Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of a-crystallin in mouse lenses. Exp Eye Res. 2019 05; 182:1-9.
    View in: PubMed
    Score: 0.585
  8. Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH. Succinylation Is a Gain-of-Function Modification in Human Lens aB-Crystallin. Biochemistry. 2019 03 05; 58(9):1260-1274.
    View in: PubMed
    Score: 0.583
  9. Nam MH, Nagaraj RH. Matrix-bound AGEs enhance TGF?2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation. Biochem J. 2018 04 23; 475(8):1427-1440.
    View in: PubMed
    Score: 0.551
  10. Rakete S, Nagaraj RH. UVA Light-mediated Ascorbate Oxidation in Human Lenses. Photochem Photobiol. 2017 07; 93(4):1091-1095.
    View in: PubMed
    Score: 0.508
  11. Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGF?2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 08; 33(4):631-43.
    View in: PubMed
    Score: 0.483
  12. Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-?2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 05 15; 473(10):1455-69.
    View in: PubMed
    Score: 0.476
  13. Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29; 291(18):9596-609.
    View in: PubMed
    Score: 0.475
  14. Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13; 289(24):17111-23.
    View in: PubMed
    Score: 0.418
  15. Nahomi RB, Oya-Ito T, Nagaraj RH. The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human a-crystallin. Biochim Biophys Acta. 2013 Jan; 1832(1):195-203.
    View in: PubMed
    Score: 0.373
  16. Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A. Acetylation of aA-crystallin in the human lens: effects on structure and chaperone function. Biochim Biophys Acta. 2012 Feb; 1822(2):120-9.
    View in: PubMed
    Score: 0.353
  17. Linetsky M, Kaid Johar SR, Meltretter J, Padmanabha S, Parmar T, Vasavada AR, Pischetsrieder M, Nagaraj RH. Determination of dideoxyosone precursors of AGEs in human lens proteins. Arch Biochem Biophys. 2011 Oct; 514(1-2):16-26.
    View in: PubMed
    Score: 0.345
  18. Mailankot M, Howell S, Nagaraj RH. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):609-20.
    View in: PubMed
    Score: 0.318
  19. Mailankot M, Nagaraj RH. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine. Int J Biochem Cell Biol. 2010 Sep; 42(9):1446-54.
    View in: PubMed
    Score: 0.317
  20. Mailankot M, Padmanabha S, Pasupuleti N, Major D, Howell S, Nagaraj RH. Glyoxalase I activity and immunoreactivity in the aging human lens. Biogerontology. 2009 Dec; 10(6):711-20.
    View in: PubMed
    Score: 0.308
  21. Mailankot M, Staniszewska MM, Butler H, Caprara MH, Howell S, Wang B, Doller C, Reneker LW, Nagaraj RH. Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens. Lab Invest. 2009 May; 89(5):498-512.
    View in: PubMed
    Score: 0.293
  22. Mailankot M, Smith D, Howell S, Wang B, Jacobberger JW, Stefan T, Nagaraj RH. Cell cycle arrest by kynurenine in lens epithelial cells. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5466-75.
    View in: PubMed
    Score: 0.281
  23. Puttaiah S, Biswas A, Staniszewska M, Nagaraj RH. Methylglyoxal inhibits glycation-mediated loss in chaperone function and synthesis of pentosidine in alpha-crystallin. Exp Eye Res. 2007 May; 84(5):914-21.
    View in: PubMed
    Score: 0.253
  24. Oya-Ito T, Liu BF, Nagaraj RH. Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27. J Cell Biochem. 2006 Sep 01; 99(1):279-91.
    View in: PubMed
    Score: 0.246
  25. Staniszewska MM, Nagaraj RH. 3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody. J Biol Chem. 2005 Jun 10; 280(23):22154-64.
    View in: PubMed
    Score: 0.223
  26. Padayatti PS, Ng AS, Uchida K, Glomb MA, Nagaraj RH. Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses. Invest Ophthalmol Vis Sci. 2001 May; 42(6):1299-304.
    View in: PubMed
    Score: 0.170
  27. Shamsi FA, Sharkey E, Creighton D, Nagaraj RH. Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res. 2000 Mar; 70(3):369-80.
    View in: PubMed
    Score: 0.157
  28. Shamsi FA, Nagaraj RH. Immunochemical detection of dicarbonyl-derived imidazolium protein crosslinks in human lenses. Curr Eye Res. 1999 Sep; 19(3):276-84.
    View in: PubMed
    Score: 0.151
  29. Nagaraj RH, Shamsi FA, Huber B, Pischetsrieder M. Immunochemical detection of oxalate monoalkylamide, an ascorbate-derived Maillard reaction product in the human lens. FEBS Lett. 1999 Jun 25; 453(3):327-30.
    View in: PubMed
    Score: 0.149
  30. Shamsi FA, Lin K, Sady C, Nagaraj RH. Methylglyoxal-derived modifications in lens aging and cataract formation. Invest Ophthalmol Vis Sci. 1998 Nov; 39(12):2355-64.
    View in: PubMed
    Score: 0.143
  31. Nahomi RB, Nagaraj RH. The role of HIF-1a in the TGF-?2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells. J Cell Biochem. 2018 08; 119(8):6814-6827.
    View in: PubMed
    Score: 0.138
  32. Nagaraj RH, Kern TS, Sell DR, Fogarty J, Engerman RL, Monnier VM. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes. 1996 May; 45(5):587-94.
    View in: PubMed
    Score: 0.120
  33. Nagaraj RH, Sady C. The presence of a glucose-derived Maillard reaction product in the human lens. FEBS Lett. 1996 Mar 18; 382(3):234-8.
    View in: PubMed
    Score: 0.119
  34. Panda AK, Nandi SK, Chakraborty A, Nagaraj RH, Biswas A. Differential role of arginine mutations on the structure and functions of a-crystallin. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):199-210.
    View in: PubMed
    Score: 0.113
  35. Holm T, Raghavan CT, Nahomi R, Nagaraj RH, Kessel L. Effects of photobleaching on selected advanced glycation end products in the human lens. BMC Res Notes. 2015 Jan 16; 8:5.
    View in: PubMed
    Score: 0.110
  36. Nahomi RB, DiMauro MA, Wang B, Nagaraj RH. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem J. 2015 Jan 01; 465(1):115-25.
    View in: PubMed
    Score: 0.109
  37. Nagaraj RH, Sell DR, Prabhakaram M, Ortwerth BJ, Monnier VM. High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10257-61.
    View in: PubMed
    Score: 0.088
  38. Nagaraj RH, Padmanabha S, Mailankot M, Staniszewska M, Mun LJ, Glomb MA, Linetsky MD. Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins. Biochim Biophys Acta. 2010 Apr; 1804(4):829-38.
    View in: PubMed
    Score: 0.077
  39. Nagaraj RH, Biswas A, Miller A, Oya-Ito T, Bhat M. The other side of the Maillard reaction. Ann N Y Acad Sci. 2008 Apr; 1126:107-12.
    View in: PubMed
    Score: 0.069
  40. Staniszewska M, Nagaraj RH. Detection of kynurenine modifications in proteins using a monoclonal antibody. J Immunol Methods. 2007 Jul 31; 324(1-2):63-73.
    View in: PubMed
    Score: 0.065
  41. Padival S, Nagaraj RH. Pyridoxamine inhibits maillard reactions in diabetic rat lenses. Ophthalmic Res. 2006; 38(5):294-302.
    View in: PubMed
    Score: 0.062
  42. Nagaraj RH, Oya-Ito T, Padayatti PS, Kumar R, Mehta S, West K, Levison B, Sun J, Crabb JW, Padival AK. Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification. Biochemistry. 2003 Sep 16; 42(36):10746-55.
    View in: PubMed
    Score: 0.050
  43. Sady C, Jiang CL, Chellan P, Madhun Z, Duve Y, Glomb MA, Nagaraj RH. Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins. Biochim Biophys Acta. 2000 Sep 29; 1481(2):255-64.
    View in: PubMed
    Score: 0.041
  44. Nagaraj RH, Monnier VM. Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose. Biochim Biophys Acta. 1992 Mar 05; 1116(1):34-42.
    View in: PubMed
    Score: 0.022
  45. Monnier VM, Nagaraj RH, Portero-Otin M, Glomb M, Elgawish AH, Sell DR, Friedlander MA. Structure of advanced Maillard reaction products and their pathological role. Nephrol Dial Transplant. 1996; 11 Suppl 5:20-6.
    View in: PubMed
    Score: 0.007
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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