 Connection
Gregory Downey to Animals
This is a "connection" page, showing publications Gregory Downey has written about Animals.
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Connection Strength |
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0.923 |
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Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 12 15; 206(12):1463-1479.
Score: 0.048
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Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. PTPa promotes fibroproliferative responses after acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L69-L83.
Score: 0.047
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Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Protein tyrosine phosphatase-a amplifies transforming growth factor-?-dependent profibrotic signaling in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L294-L311.
Score: 0.041
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Aschner Y, Downey GP. The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not. Am J Respir Cell Mol Biol. 2018 11; 59(5):535-547.
Score: 0.036
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Aschner Y, Downey GP. Transforming Growth Factor-?: Master Regulator of the Respiratory System in Health and Disease. Am J Respir Cell Mol Biol. 2016 05; 54(5):647-55.
Score: 0.031
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Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73.
Score: 0.030
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Aschner Y, Zemans RL, Yamashita CM, Downey GP. Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest. 2014 Oct; 146(4):1081-1091.
Score: 0.027
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Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-? responsiveness. Am J Pathol. 2014 May; 184(5):1489-502.
Score: 0.026
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Matute-Bello G, Downey GP. Reply: defining lung injury in animals. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):267-8.
Score: 0.024
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Vij N, Downey GP. The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):120-2.
Score: 0.024
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Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP. Role of ?-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15; 304(6):L415-27.
Score: 0.024
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Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47.
Score: 0.022
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Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5.
Score: 0.022
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Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45.
Score: 0.022
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Moraes TJ, Rafii B, Niessen F, Suzuki T, Martin R, Vachon E, Vogel W, Ruf W, O'Brodovich H, Downey GP. Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function. Exp Lung Res. 2009 Mar; 35(2):136-54.
Score: 0.019
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Kwok V, Vachon E, Downey GP. Use of fluorescent probes to detect lipid signaling intermediates in macrophages. Methods Mol Biol. 2009; 531:301-28.
Score: 0.018
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Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 May; 40(5):519-35.
Score: 0.018
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Moraes TJ, Martin R, Plumb JD, Vachon E, Cameron CM, Danesh A, Kelvin DJ, Ruf W, Downey GP. Role of PAR2 in murine pulmonary pseudomonal infection. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L368-77.
Score: 0.017
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Zemans R, Downey GP. Role of caveolin-1 in regulation of inflammation: different strokes for different folks. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L175-7.
Score: 0.017
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Vachon E, Martin R, Kwok V, Cherepanov V, Chow CW, Doerschuk CM, Plumb J, Grinstein S, Downey GP. CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood. 2007 Dec 15; 110(13):4492-502.
Score: 0.017
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Juvet SC, McCormack FX, Kwiatkowski DJ, Downey GP. Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):398-408.
Score: 0.016
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Fialkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 2007 Jan 15; 42(2):153-64.
Score: 0.016
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Herrera Abreu MT, Wang Q, Vachon E, Suzuki T, Chow CW, Wang Y, Hong O, Villar J, McCulloch CA, Downey GP. Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions. J Cell Physiol. 2006 Apr; 207(1):132-43.
Score: 0.015
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Vachon E, Martin R, Plumb J, Kwok V, Vandivier RW, Glogauer M, Kapus A, Wang X, Chow CW, Grinstein S, Downey GP. CD44 is a phagocytic receptor. Blood. 2006 May 15; 107(10):4149-58.
Score: 0.015
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Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006 Jan; 13(1):21-7.
Score: 0.015
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Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97.
Score: 0.015
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Moraes TJ, Downey GP. Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase. Microbes Infect. 2003 Nov; 5(14):1293-8.
Score: 0.013
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Chow CW, Herrera Abreu MT, Suzuki T, Downey GP. Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):427-31.
Score: 0.013
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Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. Clustering of phosphatase RPTPa promotes Src signaling and the arthritogenic action of synovial fibroblasts. Sci Signal. 2023 07 04; 16(792):eabn8668.
Score: 0.013
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MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. J Biol Chem. 2003 Jul 18; 278(29):27190-8.
Score: 0.012
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Kulkarni HS, Lee JS, Downey GP, Matute-Bello G. Reply: Experimental Acute Lung Injury in Animals: With Age Comes Knowledge. Am J Respir Cell Mol Biol. 2022 08; 67(2):267.
Score: 0.012
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Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, No?l A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14.
Score: 0.011
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Berman R, Min E, Huang J, Kopf K, Downey GP, Riemondy K, Smith HA, Rose CS, Seibold MA, Chu HW, Day BJ. Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen. Toxicol Sci. 2021 08 03; 182(2):297-309.
Score: 0.011
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McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, C?t? L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 02 01; 49(2):311-323.
Score: 0.011
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Berman R, Kopf KW, Min E, Huang J, Downey GP, Alam R, Chu HW, Day BJ. IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice. Toxicol Appl Pharmacol. 2020 10 01; 404:115186.
Score: 0.010
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Wang Q, Notay K, Downey GP, McCulloch CA. The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation. Cell Rep. 2020 06 30; 31(13):107781.
Score: 0.010
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Reinhard J, Wiemann S, Joachim SC, Palmhof M, Woestmann J, Denecke B, Wang Y, Downey GP, Faissner A. Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration. Mol Neurobiol. 2019 Jun; 56(6):4322-4345.
Score: 0.009
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Wang Q, Wang Y, Downey GP, Plotnikov S, McCulloch CA. A ternary complex comprising FAK, PTPa and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. Biochem J. 2016 Feb 15; 473(4):397-410.
Score: 0.007
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Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2.
Score: 0.007
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Baral P, Batra S, Zemans RL, Downey GP, Jeyaseelan S. Divergent functions of Toll-like receptors during bacterial lung infections. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):722-32.
Score: 0.007
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Wang Q, Wang Y, Fritz D, Rajshankar D, Downey GP, McCulloch CA. Interactions of the protein-tyrosine phosphatase-a with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts. J Biol Chem. 2014 Jun 27; 289(26):18427-41.
Score: 0.007
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Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37.
Score: 0.007
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Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M, Downey GP, McCulloch CA. Role of PTPa in the destruction of periodontal connective tissues. PLoS One. 2013; 8(8):e70659.
Score: 0.006
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Wang Q, Siminovitch KA, Downey GP, McCulloch CA. Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLC? at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression. Biochem J. 2013 Feb 01; 449(3):771-82.
Score: 0.006
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Rajshankar D, Downey GP, McCulloch CA. IL-1? enhances cell adhesion to degraded fibronectin. FASEB J. 2012 Nov; 26(11):4429-44.
Score: 0.006
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Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med. 2012 Jul 11; 4(142):142ra95.
Score: 0.006
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Finigan JH, Downey GP, Kern JA. Human epidermal growth factor receptor signaling in acute lung injury. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):395-404.
Score: 0.006
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Flannagan RS, Jaumouill? V, Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S. Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42. Cell Microbiol. 2012 Feb; 14(2):239-54.
Score: 0.006
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Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8.
Score: 0.005
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Wang Q, Downey GP, McCulloch CA. Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK. FASEB J. 2011 Oct; 25(10):3448-64.
Score: 0.005
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Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011 May; 44(5):725-38.
Score: 0.005
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Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S. Inactivation of macrophage Rab7 by Burkholderia cenocepacia. J Innate Immun. 2010; 2(6):522-33.
Score: 0.005
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Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey GP, McCulloch CA. Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression. J Biol Chem. 2010 Jul 16; 285(29):22308-17.
Score: 0.005
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Henson PM, Downey GP, Irvin CG. It's much more than just pretty pictures. Am J Respir Cell Mol Biol. 2010 May; 42(5):515-6.
Score: 0.005
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Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86.
Score: 0.005
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Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA. Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling. J Biol Chem. 2009 Jul 31; 284(31):20763-72.
Score: 0.005
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Voglis S, Quinn K, Tullis E, Liu M, Henriques M, Zubrinich C, Pe?uelas O, Chan H, Silverman F, Cherepanov V, Orzech N, Khine AA, Cantin A, Slutsky AS, Downey GP, Zhang H. Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. Am J Respir Crit Care Med. 2009 Jul 15; 180(2):159-66.
Score: 0.005
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Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, Worthen GS. A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction. J Immunol Methods. 2009 Jan 30; 340(2):102-15.
Score: 0.005
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Shalev I, Liu H, Koscik C, Bartczak A, Javadi M, Wong KM, Maknojia A, He W, Liu MF, Diao J, Winter E, Manuel J, McCarthy D, Cattral M, Gommerman J, Clark DA, Phillips MJ, Gorczynski RR, Zhang L, Downey G, Grant D, Cybulsky MI, Levy G. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol. 2008 Jan 01; 180(1):249-60.
Score: 0.004
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De Albuquerque N, Baig E, Ma X, Zhang J, He W, Rowe A, Habal M, Liu M, Shalev I, Downey GP, Gorczynski R, Butany J, Leibowitz J, Weiss SR, McGilvray ID, Phillips MJ, Fish EN, Levy GA. Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol. 2006 Nov; 80(21):10382-94.
Score: 0.004
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Greenwood HL, Singer PA, Downey GP, Martin DK, Thorsteinsd?ttir H, Daar AS. Regenerative medicine and the developing world. PLoS Med. 2006 Sep; 3(9):e381.
Score: 0.004
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Wang Q, Herrera Abreu MT, Siminovitch K, Downey GP, McCulloch CA. Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling. J Biol Chem. 2006 Oct 13; 281(41):31093-105.
Score: 0.004
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Guilbault C, Saeed Z, Downey GP, Radzioch D. Cystic fibrosis mouse models. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):1-7.
Score: 0.004
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Aoki CR, Liu H, Downey GP, Mitchell J, Horner RL. Cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):555-65.
Score: 0.004
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Peterson MD, Vlasova E, Di Ciano-Oliveira C, Downey GP, Cybulsky MI, Kapus A, Waddell TK. Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation. Am J Transplant. 2005 Feb; 5(2):237-47.
Score: 0.004
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Wang Q, Downey GP, Herrera-Abreu MT, Kapus A, McCulloch CA. SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1. J Biol Chem. 2005 Mar 04; 280(9):8397-406.
Score: 0.003
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Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem. 2005 Mar 04; 280(9):7519-29.
Score: 0.003
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Koehler DR, Downey GP, Sweezey NB, Tanswell AK, Hu J. Lung inflammation as a therapeutic target in cystic fibrosis. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):377-81.
Score: 0.003
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Sun CX, Downey GP, Zhu F, Koh AL, Thang H, Glogauer M. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood. 2004 Dec 01; 104(12):3758-65.
Score: 0.003
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Chow CW, Downey GP, Grinstein S. Measurements of phagocytosis and phagosomal maturation. Curr Protoc Cell Biol. 2004 May; Chapter 15:Unit 15.7.
Score: 0.003
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Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003 Jun 01; 170(11):5652-7.
Score: 0.003
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Tabata T, de Perrot M, Keshavjee S, Liu M, Downey GP, Waddell TK. Accommodation after lung xenografting from hamster to rat. Transplantation. 2003 Mar 15; 75(5):607-12.
Score: 0.003
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Luo X, Belcastro R, Cabacungan J, Hannam V, Negus A, Wen Y, Plumb J, Hu J, Steer B, Koehler DR, Downey GP, Tanswell AK. Transfection of lung cells in vitro and in vivo: effect of antioxidants and intraliposomal bFGF. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L817-25.
Score: 0.003
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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