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Connection

Paul Buehler to Animals

This is a "connection" page, showing publications Paul Buehler has written about Animals.

 
Connection Strength
  
 
 
1.140
  
  1. Lamb DR, Greenfield A, Thangaraju K, Setua S, Eiker G, Wang Q, Vahedi A, Khan MA, Yahya A, Cabrales P, Palmer AF, Buehler PW. The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and Resuscitation. Mol Pharm. 2023 11 06; 20(11):5739-5752.
    View in: PubMed
    Score: 0.046
  2. Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 11 01; 175:95-107.
    View in: PubMed
    Score: 0.040
  3. Baek JH, Shin HKH, Koo SM, Gao Y, Qu H, Feng X, Xu X, Pinto J, Katneni U, Kimchi-Sarfaty C, Buehler PW. Polyethylene Oxide Molecular Size Determines the Severity of Atypical Thrombotic Microangiopathy in a Guinea Pig Model of Acute Intravenous Exposure. Toxicol Sci. 2020 09 01; 177(1):235-247.
    View in: PubMed
    Score: 0.037
  4. Buehler PW, Humar R, Schaer DJ. Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity. Trends Mol Med. 2020 07; 26(7):683-697.
    View in: PubMed
    Score: 0.036
  5. Tarandovskiy ID, Shin HKH, Baek JH, Karnaukhova E, Buehler PW. Interspecies comparison of simultaneous thrombin and plasmin generation. Sci Rep. 2020 03 03; 10(1):3885.
    View in: PubMed
    Score: 0.036
  6. Baek JH, Shin HKH, Gao Y, Buehler PW. Ferroportin inhibition attenuates plasma iron, oxidant stress, and renal injury following red blood cell transfusion in guinea pigs. Transfusion. 2020 03; 60(3):513-523.
    View in: PubMed
    Score: 0.036
  7. Baek JH, Buehler PW. Can molecular markers of oxygen homeostasis and the measurement of tissue oxygen be leveraged to optimize red blood cell transfusions? Curr Opin Hematol. 2019 11; 26(6):453-460.
    View in: PubMed
    Score: 0.035
  8. Hou H, Baek JH, Zhang H, Wood F, Gao Y, Flood AB, Swartz HM, Buehler PW. Electron paramagnetic resonance oximetry as a novel approach to monitor the effectiveness and quality of red blood cell transfusions. Blood Transfus. 2019 07; 17(4):296-306.
    View in: PubMed
    Score: 0.034
  9. Baek JH, Yalamanoglu A, Brown RP, Saylor DM, Malinauskas RA, Buehler PW. Renal Toxicodynamic Effects of Extracellular Hemoglobin After Acute Exposure. Toxicol Sci. 2018 11 01; 166(1):180-191.
    View in: PubMed
    Score: 0.033
  10. Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schaer DJ, Buehler PW. Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L765-L774.
    View in: PubMed
    Score: 0.032
  11. Baek JH, Yalamanoglu A, Moon SE, Gao Y, Buehler PW. Evaluation of renal oxygen homeostasis in a preclinical animal model to elucidate difference in blood quality after transfusion. Transfusion. 2018 06; 58(6):1474-1485.
    View in: PubMed
    Score: 0.031
  12. Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 May; 82:50-62.
    View in: PubMed
    Score: 0.025
  13. Gelderman MP, Baek JH, Yalamanoglu A, Puglia M, Vallelian F, Burla B, Vostal J, Schaer DJ, Buehler PW. Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice. Haematologica. 2015 May; 100(5):611-22.
    View in: PubMed
    Score: 0.025
  14. Schaer DJ, Buehler PW. Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harb Perspect Med. 2013 Jun 01; 3(6).
    View in: PubMed
    Score: 0.022
  15. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26.
    View in: PubMed
    Score: 0.021
  16. Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest. 2012 Apr; 122(4):1444-58.
    View in: PubMed
    Score: 0.021
  17. Baek JH, Zhou Y, Harris DR, Schaer DJ, Palmer AF, Buehler PW. Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicol Sci. 2012 Jun; 127(2):567-81.
    View in: PubMed
    Score: 0.021
  18. Buehler PW, Butt OI, D'Agnillo F. Sodium nitrite induces acute central nervous system toxicity in guinea pigs exposed to systemic cell-free hemoglobin. Biochem Biophys Res Commun. 2011 Jun 10; 409(3):412-7.
    View in: PubMed
    Score: 0.019
  19. Buehler PW, Karnaukhova E, Gelderman MP, Alayash AI. Blood aging, safety, and transfusion: capturing the "radical" menace. Antioxid Redox Signal. 2011 May 01; 14(9):1713-28.
    View in: PubMed
    Score: 0.019
  20. Buehler PW, D'Agnillo F, Schaer DJ. Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med. 2010 Oct; 16(10):447-57.
    View in: PubMed
    Score: 0.018
  21. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35.
    View in: PubMed
    Score: 0.018
  22. Buehler PW, D'Agnillo F. Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives. Antioxid Redox Signal. 2010 Feb; 12(2):275-91.
    View in: PubMed
    Score: 0.018
  23. Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ. Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood. 2009 Mar 12; 113(11):2578-86.
    View in: PubMed
    Score: 0.017
  24. Cooper CE, Silaghi-Dumitrescu R, Rukengwa M, Alayash AI, Buehler PW. Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC). Biochim Biophys Acta. 2008 Oct; 1784(10):1415-20.
    View in: PubMed
    Score: 0.016
  25. Buehler PW, D'Agnillo F, Hoffman V, Alayash AI. Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther. 2007 Oct; 323(1):49-60.
    View in: PubMed
    Score: 0.015
  26. Schaer DJ, Alayash AI, Buehler PW. Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal. 2007 Jul; 9(7):991-9.
    View in: PubMed
    Score: 0.015
  27. Alayash AI, D'Agnillo F, Buehler PW. First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther. 2007 May; 7(5):665-75.
    View in: PubMed
    Score: 0.015
  28. Buehler PW, Alayash AI. Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity. Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1755-60.
    View in: PubMed
    Score: 0.013
  29. Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem. 2005 Jun 01; 77(11):3466-78.
    View in: PubMed
    Score: 0.013
  30. Rana NK, Lisk C, Cendali F, Lucero MJ, Grier A, Setua S, Thangaraju K, Khan A, Reisz JA, Dzieciatkowska M, Pak DI, Swindle D, Danaher MX, Khan S, Westover N, Carter M, Hassell K, Nuss R, George G, Buehler PW, D'Alessandro A, Irwin DC. Metabolic and Proteomic Divergence is Present in Spleens and Livers from Berkeley Sickle Cell Anemia and ?-Thalassemia Mice. J Proteome Res. 2025 Mar 07; 24(3):1306-1316.
    View in: PubMed
    Score: 0.013
  31. Cendali FI, Lisk C, Dzieciatkowska M, LaCroix IS, Reisz JA, Harral J, Stephenson D, Hay AM, Wartchow EP, Darehshouri A, Dziewulska-Cronk KH, Buehler PW, Norris PJ, Deng X, Busch MP, Earley EJ, Page GP, Hansen KC, Zimring JC, Irwin DC, Nemkov T, D'Alessandro A. Increased exercise tolerance in humanized G6PD-deficient mice. Blood Adv. 2025 Jan 28; 9(2):321-334.
    View in: PubMed
    Score: 0.013
  32. Lucero MJ, Lisk C, Cendali F, Swindle D, Setua S, Thangaraju K, Pak DI, O'Boyle Q, Lu S, Tolson R, Zaeske S, Rana N, Khan S, Westover N, DavizonCastillo P, George G, Hassell K, Nuss R, Brinkman N, Gentinetta T, Palmer AF, D'Alessandro A, Buehler PW, Irwin DC. Targeting lung heme iron by aerosol hemopexin adminstration in sickle cell disease pulmonary hypertension. Free Radic Biol Med. 2025 Mar 01; 229:458-473.
    View in: PubMed
    Score: 0.013
  33. Buehler PW, Alayash AI. Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature. Antioxid Redox Signal. 2004 Dec; 6(6):1000-10.
    View in: PubMed
    Score: 0.012
  34. Buehler PW, Alayash AI. Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion. 2004 Oct; 44(10):1516-30.
    View in: PubMed
    Score: 0.012
  35. Dziewulska-Cronk KH, Reisz JA, Hay AM, Nemkov T, Cendali FI, Issaian A, Lamb DR, Palha MS, Legenzov EA, Kao JPY, Walker LA, Tekwani BL, Buehler PW, D'Alessandro A, Zimring JC. Primaquine-5,6-Orthoquinone Is Directly Hemolytic to Older G6PD Deficient RBCs in a Humanized Mouse Model. J Pharmacol Exp Ther. 2024 Sep 18; 391(1):119-129.
    View in: PubMed
    Score: 0.012
  36. Baek JH, Shin HKH, Xu F, Zhang X, Williams MC, Gao Y, Vostal JG, Buehler PW, Villa C, D'Agnillo F. Ultraviolet light and riboflavin accelerates red blood cell dysfunction in vitro and in a guinea pig transfusion model. Blood Transfus. 2024 Jul 15; 22(4):316-327.
    View in: PubMed
    Score: 0.012
  37. Buehler PW, Haney CR, Gulati A, Ma L, Hsia CJ. Polynitroxyl hemoglobin: a pharmacokinetic study of covalently bound nitroxides to hemoglobin platforms. Free Radic Biol Med. 2004 Jul 01; 37(1):124-35.
    View in: PubMed
    Score: 0.012
  38. Cuddington C, Greenfield A, Lee YG, Kim JL, Lamb D, Buehler PW, Black SM, Palmer AF, Whitson BA. Polymerized Human Hemoglobin-Based Oxygen Carrier Preserves Lung Allograft Function During Normothermic Ex Vivo Lung Perfusion. ASAIO J. 2024 05 01; 70(5):442-450.
    View in: PubMed
    Score: 0.012
  39. Kim CY, Larsen HJ, Spitalnik SL, Hod EA, Francis RO, Hudson KE, Gordy DE, Stone EF, Peltier S, Amireault P, D'Alessandro A, Zimring JC, Buehler PW, Fu X, Thomas T. Low-Dose Dietary Fish Oil Improves RBC Deformability without Improving Post-Transfusion Recovery in Mice. Nutrients. 2023 Oct 20; 15(20).
    View in: PubMed
    Score: 0.012
  40. Lisk C, Cendali F, Setua S, Thangaraju K, Pak DI, Swindle D, Dzieciatkowska M, Gamboni F, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Metabolic and Proteomic Divergence Is Present in Circulating Monocytes and Tissue-Resident Macrophages from Berkeley Sickle Cell Anemia and ?-Thalassemia Mice. J Proteome Res. 2023 09 01; 22(9):2925-2935.
    View in: PubMed
    Score: 0.011
  41. Greenfield A, Lamb DR, Gu X, Thangaraju K, Setua S, Yahya A, Vahedi A, Khan MA, Wang Q, Buehler PW, Palmer AF. Biophysical Analysis and Preclinical Pharmacokinetics-Pharmacodynamics of Tangential Flow Filtration Fractionated Polymerized Human Hemoglobin as a Red Blood Cell Substitute. Biomacromolecules. 2023 04 10; 24(4):1855-1870.
    View in: PubMed
    Score: 0.011
  42. Nyffenegger N, Zennadi R, Kalleda N, Flace A, Ingoglia G, Buzzi RM, Doucerain C, Buehler PW, Schaer DJ, D?rrenberger F, Manolova V. The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease. Blood. 2022 08 18; 140(7):769-781.
    View in: PubMed
    Score: 0.011
  43. Miglio A, Maslanka M, Di Tommaso M, Rocconi F, Nemkov T, Buehler PW, Antognoni MT, Spitalnik SL, D'Alessandro A. ZOOMICS : comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days. Blood Transfus. 2023 07; 21(4):314-326.
    View in: PubMed
    Score: 0.011
  44. Chiou WL, Buehler PW. Comparison of oral absorption and bioavailablity of drugs between monkey and human. Pharm Res. 2002 Jun; 19(6):868-74.
    View in: PubMed
    Score: 0.010
  45. Buzzi RM, Owczarek CM, Akeret K, Tester A, Pereira N, Butcher R, Br?gger-Verdon V, Hardy MP, Illi M, Wassmer A, Vallelian F, Humar R, Hugelshofer M, Buehler PW, Gentinetta T, Schaer DJ. Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics. Mol Pharm. 2021 08 02; 18(8):3158-3170.
    View in: PubMed
    Score: 0.010
  46. Thomas T, Cendali F, Fu X, Gamboni F, Morrison EJ, Beirne J, Nemkov T, Antonelou MH, Kriebardis A, Welsby I, Hay A, Dziewulska KH, Busch MP, Kleinman S, Buehler PW, Spitalnik SL, Zimring JC, D'Alessandro A. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. Transfusion. 2021 06; 61(6):1867-1883.
    View in: PubMed
    Score: 0.010
  47. Yalamanoglu A, Dubach IL, Schulthess N, Ingoglia G, Swindle DC, Humar R, Schaer DJ, Buehler PW, Irwin DC, Vallelian F. Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice. Front Immunol. 2021; 12:627944.
    View in: PubMed
    Score: 0.010
  48. Katneni UK, Alexaki A, Hunt RC, Schiller T, DiCuccio M, Buehler PW, Ibla JC, Kimchi-Sarfaty C. Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost. 2020 Dec; 120(12):1668-1679.
    View in: PubMed
    Score: 0.009
  49. Ferguson SK, Redinius KM, Harral JW, Pak DI, Swindle DC, Hirai DM, Blackwell JR, Jones AM, Stenmark KR, Buehler PW, Irwin DC. The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease. J Appl Physiol (1985). 2020 09 01; 129(3):474-482.
    View in: PubMed
    Score: 0.009
  50. Munoz CJ, Pires IS, Baek JH, Buehler PW, Palmer AF, Cabrales P. Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme. Am J Physiol Heart Circ Physiol. 2020 05 01; 318(5):H1296-H1307.
    View in: PubMed
    Score: 0.009
  51. Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ. Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. J Clin Invest. 2019 12 02; 129(12):5219-5235.
    View in: PubMed
    Score: 0.009
  52. Stefanoni D, Shin HKH, Baek JH, Champagne DP, Nemkov T, Thomas T, Francis RO, Zimring JC, Yoshida T, Reisz JA, Spitalnik SL, Buehler PW, D'Alessandro A. Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage. Haematologica. 2020 08; 105(8):2174-2186.
    View in: PubMed
    Score: 0.009
  53. Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 08 08; 4(15).
    View in: PubMed
    Score: 0.009
  54. Edmondson M, Jana S, Meng F, Strader MB, Baek JH, Gao Y, Buehler PW, Alayash AI. Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts. Free Radic Biol Med. 2019 09; 141:348-361.
    View in: PubMed
    Score: 0.009
  55. Saylor DM, Buehler PW, Brown RP, Malinauskas RA. Predicting Plasma Free Hemoglobin Levels in Patients Due to Medical Device-Related Hemolysis. ASAIO J. 2019 Mar/Apr; 65(3):207-218.
    View in: PubMed
    Score: 0.008
  56. Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2019 02; 597(4):1073-1085.
    View in: PubMed
    Score: 0.008
  57. Vallelian F, Schaer CA, Deuel JW, Ingoglia G, Humar R, Buehler PW, Schaer DJ. Revisiting the putative role of heme as a trigger of inflammation. Pharmacol Res Perspect. 2018 04; 6(2):e00392.
    View in: PubMed
    Score: 0.008
  58. Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ. Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics. BMC Biotechnol. 2018 03 15; 18(1):15.
    View in: PubMed
    Score: 0.008
  59. Ferguson SK, Harral JW, Pak DI, Redinius KM, Stenmark KR, Schaer DJ, Buehler PW, Irwin DC. Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics. Nitric Oxide. 2018 06 01; 76:29-36.
    View in: PubMed
    Score: 0.008
  60. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 01; 58(1):255-266.
    View in: PubMed
    Score: 0.008
  61. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(2):e0171219.
    View in: PubMed
    Score: 0.007
  62. Hunt R, Yalamanoglu A, Tumlin J, Schiller T, Baek JH, Wu A, Fogo AB, Yang H, Wong E, Miller P, Buehler PW, Kimchi-Sarfaty C. A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER. Blood. 2017 02 16; 129(7):896-905.
    View in: PubMed
    Score: 0.007
  63. Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 05 15; 193(10):1111-22.
    View in: PubMed
    Score: 0.007
  64. Baek JH, Zhang X, Williams MC, Hicks W, Buehler PW, D'Agnillo F. Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs. Toxicology. 2015 Jul 03; 333:89-99.
    View in: PubMed
    Score: 0.006
  65. Vallelian F, Gelderman-Fuhrmann MP, Schaer CA, Puglia M, Opitz L, Baek JH, Vostal J, Buehler PW, Schaer DJ. Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia. J Proteome Res. 2015 Feb 06; 14(2):1089-100.
    View in: PubMed
    Score: 0.006
  66. Baek JH, Zhang X, Williams MC, Schaer DJ, Buehler PW, D'Agnillo F. Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin. Toxins (Basel). 2014 Mar 31; 6(4):1244-59.
    View in: PubMed
    Score: 0.006
  67. Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ. Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. Antioxid Redox Signal. 2013 Nov 10; 19(14):1619-33.
    View in: PubMed
    Score: 0.006
  68. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013 Feb 21; 121(8):1276-84.
    View in: PubMed
    Score: 0.005
  69. Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1a) and induces hepcidin (Hamp) in rat kidney. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):421-6.
    View in: PubMed
    Score: 0.005
  70. Zhou Y, Jia Y, Buehler PW, Chen G, Cabrales P, Palmer AF. Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnol Prog. 2011 Jul; 27(4):1172-84.
    View in: PubMed
    Score: 0.005
  71. Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Induction of hypoxia inducible factor (HIF-1a) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):262-8.
    View in: PubMed
    Score: 0.005
  72. Butt OI, Buehler PW, D'Agnillo F. Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol. 2011 Mar; 178(3):1316-28.
    View in: PubMed
    Score: 0.005
  73. Elmer J, Buehler PW, Jia Y, Wood F, Harris DR, Alayash AI, Palmer AF. Functional comparison of hemoglobin purified by different methods and their biophysical implications. Biotechnol Bioeng. 2010 May 01; 106(1):76-85.
    View in: PubMed
    Score: 0.005
  74. Butt OI, Buehler PW, D'Agnillo F. Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin. Antioxid Redox Signal. 2010 Feb; 12(2):199-208.
    View in: PubMed
    Score: 0.004
  75. Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest. 2009 Aug; 119(8):2271-80.
    View in: PubMed
    Score: 0.004
  76. Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):200-9.
    View in: PubMed
    Score: 0.004
  77. Manalo DJ, Buehler PW, Baek JH, Butt O, D'agnillo F, Alayash AI. Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats. Biochem J. 2008 Sep 15; 414(3):461-9.
    View in: PubMed
    Score: 0.004
  78. Dunne J, Caron A, Menu P, Alayash AI, Buehler PW, Wilson MT, Silaghi-Dumitrescu R, Faivre B, Cooper CE. Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochem J. 2006 Nov 01; 399(3):513-24.
    View in: PubMed
    Score: 0.004
  79. Haney CR, Buehler PW, Gulati A. Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier. Biochim Biophys Acta. 2005 Oct 10; 1725(3):358-69.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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