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Connection

Paul Buehler to Humans

This is a "connection" page, showing publications Paul Buehler has written about Humans.

 
Connection Strength
  
 
 
0.269
  
  1. Baek JH, Buehler PW. Can molecular markers of oxygen homeostasis and the measurement of tissue oxygen be leveraged to optimize red blood cell transfusions? Curr Opin Hematol. 2019 11; 26(6):453-460.
    View in: PubMed
    Score: 0.019
  2. Baek JH, Yalamanoglu A, Brown RP, Saylor DM, Malinauskas RA, Buehler PW. Renal Toxicodynamic Effects of Extracellular Hemoglobin After Acute Exposure. Toxicol Sci. 2018 11 01; 166(1):180-191.
    View in: PubMed
    Score: 0.017
  3. Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schaer DJ, Buehler PW. Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L765-L774.
    View in: PubMed
    Score: 0.017
  4. Schaer DJ, Buehler PW. Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harb Perspect Med. 2013 Jun 01; 3(6).
    View in: PubMed
    Score: 0.012
  5. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26.
    View in: PubMed
    Score: 0.011
  6. Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest. 2012 Apr; 122(4):1444-58.
    View in: PubMed
    Score: 0.011
  7. Buehler PW, Karnaukhova E, Gelderman MP, Alayash AI. Blood aging, safety, and transfusion: capturing the "radical" menace. Antioxid Redox Signal. 2011 May 01; 14(9):1713-28.
    View in: PubMed
    Score: 0.010
  8. Buehler PW, D'Agnillo F, Schaer DJ. Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med. 2010 Oct; 16(10):447-57.
    View in: PubMed
    Score: 0.010
  9. Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ. Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood. 2009 Mar 12; 113(11):2578-86.
    View in: PubMed
    Score: 0.009
  10. Buehler PW, Vallelian F, Mikolajczyk MG, Schoedon G, Schweizer T, Alayash AI, Schaer DJ. Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxid Redox Signal. 2008 Aug; 10(8):1449-62.
    View in: PubMed
    Score: 0.009
  11. Cooper CE, Silaghi-Dumitrescu R, Rukengwa M, Alayash AI, Buehler PW. Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC). Biochim Biophys Acta. 2008 Oct; 1784(10):1415-20.
    View in: PubMed
    Score: 0.008
  12. Buehler PW, Alayash AI. All hemoglobin-based oxygen carriers are not created equally. Biochim Biophys Acta. 2008 Oct; 1784(10):1378-81.
    View in: PubMed
    Score: 0.008
  13. Schaer DJ, Alayash AI, Buehler PW. Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal. 2007 Jul; 9(7):991-9.
    View in: PubMed
    Score: 0.008
  14. Alayash AI, D'Agnillo F, Buehler PW. First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther. 2007 May; 7(5):665-75.
    View in: PubMed
    Score: 0.008
  15. Buehler PW, Alayash AI. Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity. Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1755-60.
    View in: PubMed
    Score: 0.007
  16. Buehler PW, Alayash AI. Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature. Antioxid Redox Signal. 2004 Dec; 6(6):1000-10.
    View in: PubMed
    Score: 0.007
  17. Buehler PW, Alayash AI. Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion. 2004 Oct; 44(10):1516-30.
    View in: PubMed
    Score: 0.007
  18. Buehler PW, Haney CR, Gulati A, Ma L, Hsia CJ. Polynitroxyl hemoglobin: a pharmacokinetic study of covalently bound nitroxides to hemoglobin platforms. Free Radic Biol Med. 2004 Jul 01; 37(1):124-35.
    View in: PubMed
    Score: 0.006
  19. Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ. Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. J Clin Invest. 2019 12 02; 129(12):5219-5235.
    View in: PubMed
    Score: 0.005
  20. Pires IS, Belcher DA, Hickey R, Miller C, Badu-Tawiah AK, Baek JH, Buehler PW, Palmer AF. Novel manufacturing method for producing apohemoglobin and its biophysical properties. Biotechnol Bioeng. 2020 01; 117(1):125-145.
    View in: PubMed
    Score: 0.005
  21. Stefanoni D, Shin HKH, Baek JH, Champagne DP, Nemkov T, Thomas T, Francis RO, Zimring JC, Yoshida T, Reisz JA, Spitalnik SL, Buehler PW, D'Alessandro A. Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage. Haematologica. 2020 08; 105(8):2174-2186.
    View in: PubMed
    Score: 0.005
  22. Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 08 08; 4(15).
    View in: PubMed
    Score: 0.005
  23. Edmondson M, Jana S, Meng F, Strader MB, Baek JH, Gao Y, Buehler PW, Alayash AI. Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts. Free Radic Biol Med. 2019 09; 141:348-361.
    View in: PubMed
    Score: 0.005
  24. Vallelian F, Schaer CA, Deuel JW, Ingoglia G, Humar R, Buehler PW, Schaer DJ. Revisiting the putative role of heme as a trigger of inflammation. Pharmacol Res Perspect. 2018 04; 6(2):e00392.
    View in: PubMed
    Score: 0.004
  25. Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ. Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics. BMC Biotechnol. 2018 03 15; 18(1):15.
    View in: PubMed
    Score: 0.004
  26. Belcher DA, Ju JA, Baek JH, Yalamanoglu A, Buehler PW, Gilkes DM, Palmer AF. The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study. PLoS One. 2018; 13(2):e0191275.
    View in: PubMed
    Score: 0.004
  27. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 01; 58(1):255-266.
    View in: PubMed
    Score: 0.004
  28. Hunt R, Yalamanoglu A, Tumlin J, Schiller T, Baek JH, Wu A, Fogo AB, Yang H, Wong E, Miller P, Buehler PW, Kimchi-Sarfaty C. A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER. Blood. 2017 02 16; 129(7):896-905.
    View in: PubMed
    Score: 0.004
  29. Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 05 15; 193(10):1111-22.
    View in: PubMed
    Score: 0.004
  30. Deuel JW, Vallelian F, Schaer CA, Puglia M, Buehler PW, Schaer DJ. Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Radic Biol Med. 2015 Dec; 89:931-43.
    View in: PubMed
    Score: 0.004
  31. Vallelian F, Garcia-Rubio I, Puglia M, Kahraman A, Deuel JW, Engelsberger WR, Mason RP, Buehler PW, Schaer DJ. Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex. Free Radic Biol Med. 2015 Aug; 85:259-68.
    View in: PubMed
    Score: 0.003
  32. Jia Y, Wood F, Buehler PW, Alayash AI. Haptoglobin preferentially binds ? but not a subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions. PLoS One. 2013; 8(3):e59841.
    View in: PubMed
    Score: 0.003
  33. Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ. Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. Antioxid Redox Signal. 2013 Nov 10; 19(14):1619-33.
    View in: PubMed
    Score: 0.003
  34. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013 Feb 21; 121(8):1276-84.
    View in: PubMed
    Score: 0.003
  35. Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI. Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine ?145. Antioxid Redox Signal. 2013 Jun 10; 18(17):2264-73.
    View in: PubMed
    Score: 0.003
  36. Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Induction of hypoxia inducible factor (HIF-1a) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):262-8.
    View in: PubMed
    Score: 0.003
  37. Elmer J, Buehler PW, Jia Y, Wood F, Harris DR, Alayash AI, Palmer AF. Functional comparison of hemoglobin purified by different methods and their biophysical implications. Biotechnol Bioeng. 2010 May 01; 106(1):76-85.
    View in: PubMed
    Score: 0.002
  38. Widmer CC, Pereira CP, Gehrig P, Vallelian F, Schoedon G, Buehler PW, Schaer DJ. Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxid Redox Signal. 2010 Feb; 12(2):185-98.
    View in: PubMed
    Score: 0.002
  39. Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Free Radic Biol Med. 2008 Oct 15; 45(8):1150-8.
    View in: PubMed
    Score: 0.002
  40. Jia Y, Buehler PW, Boykins RA, Venable RM, Alayash AI. Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway. J Biol Chem. 2007 Feb 16; 282(7):4894-4907.
    View in: PubMed
    Score: 0.002
  41. Dunne J, Caron A, Menu P, Alayash AI, Buehler PW, Wilson MT, Silaghi-Dumitrescu R, Faivre B, Cooper CE. Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochem J. 2006 Nov 01; 399(3):513-24.
    View in: PubMed
    Score: 0.002
  42. Haney CR, Buehler PW, Gulati A. Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier. Biochim Biophys Acta. 2005 Oct 10; 1725(3):358-69.
    View in: PubMed
    Score: 0.002
  43. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A. CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood. 2006 Jan 01; 107(1):373-80.
    View in: PubMed
    Score: 0.002
  44. Boykins RA, Buehler PW, Jia Y, Venable R, Alayash AI. O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification. Proteins. 2005 Jun 01; 59(4):840-55.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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