Human articular cartilage is orthotropic where microstructure, micromechanics, and chemistry vary with depth and split-line orientation.
Fischenich KM, Wahlquist JA, Wilmoth RL, Cai L, Neu CP, Ferguson VL. Human articular cartilage is orthotropic where microstructure, micromechanics, and chemistry vary with depth and split-line orientation. Osteoarthritis Cartilage. 2020 10; 28(10):1362-1372.