VitalyKheyfetsVitaly Oleg Kheyfets39.74773620000000-104.839213600000007984Kheyfets, VitalyOlegAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:descriptiondescriptionDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 120192123699723Kheyfets VO, O'Dell W, Smith T, Reilly JJ, Finol EAJournal of biomechanical engineeringKheyfets VO, O'Dell W, Smith T, Reilly JJ, Finol EA. Considerations for numerical modeling of the pulmonary circulation--a review with a focus on pulmonary hypertension. J Biomech Eng. 2013 Jun; 135(6):61011-15.J Biomech Eng2013-06-01T00:00:002013Considerations for numerical modeling of the pulmonary circulation--a review with a focus on pulmonary hypertension.Authorship 1252351Authorship 125381125975872Kheyfets VO, Rios L, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Zikos A, Spotti J, Reilly JJ, Finol EAComputer methods and programs in biomedicineKheyfets VO, Rios L, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Zikos A, Spotti J, Reilly JJ, Finol EA. Patient-specific computational modeling of blood flow in the pulmonary arterial circulation. Comput Methods Programs Biomed. 2015 Jul; 120(2):88-101.Comput Methods Programs Biomed2015-04-28T00:00:002015Patient-specific computational modeling of blood flow in the pulmonary arterial circulation.25992274Kheyfets V, Thirugnanasambandam M, Rios L, Evans D, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Spotti J, Finol EPulmonary circulationKheyfets V, Thirugnanasambandam M, Rios L, Evans D, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Spotti J, Finol E. The role of wall shear stress in the assessment of right ventricle hydraulic workload. Pulm Circ. 2015 Mar; 5(1):90-100.Pulm Circ2015-03-01T00:00:002015The role of wall shear stress in the assessment of right ventricle hydraulic workload.Authorship 130901326376972Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter KJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceTruong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16; 17:81.J Cardiovasc Magn Reson2015-09-16T00:00:002015Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension.Authorship 135969126697173Kheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas RPulmonary circulationKheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas R. Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):658-66.Pulm Circ2015-12-01T00:00:002015Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension.Authorship 140456227076906Sch?fer M, Kheyfets VO, Schroeder JD, Dunning J, Shandas R, Buckner JK, Browning J, Hertzberg J, Hunter KS, Fenster BEPulmonary circulationSch?fer M, Kheyfets VO, Schroeder JD, Dunning J, Shandas R, Buckner JK, Browning J, Hertzberg J, Hunter KS, Fenster BE. Main pulmonary arterial wall shear stress correlates with invasive hemodynamics and stiffness in pulmonary hypertension. Pulm Circ. 2016 Mar; 6(1):37-45.Pulm Circ2016-03-01T00:00:002016Main pulmonary arterial wall shear stress correlates with invasive hemodynamics and stiffness in pulmonary hypertension.Authorship 141680527162613Sch?fer M, Browning J, Schroeder JD, Shandas R, Kheyfets VO, Buckner JK, Hunter KS, Hertzberg JR, Fenster BEPulmonary circulationSch?fer M, Browning J, Schroeder JD, Shandas R, Kheyfets VO, Buckner JK, Hunter KS, Hertzberg JR, Fenster BE. Vorticity is a marker of diastolic ventricular interdependency in pulmonary hypertension. Pulm Circ. 2016 Mar; 6(1):46-54.Pulm Circ2016-03-01T00:00:002016Vorticity is a marker of diastolic ventricular interdependency in pulmonary hypertension.Authorship 148881127173445Kheyfets VO, Schafer M, Podgorski CA, Schroeder JD, Browning J, Hertzberg J, Buckner JK, Hunter KS, Shandas R, Fenster BEJournal of magnetic resonance imaging : JMRIKheyfets VO, Schafer M, Podgorski CA, Schroeder JD, Browning J, Hertzberg J, Buckner JK, Hunter KS, Shandas R, Fenster BE. 4D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension. J Magn Reson Imaging. 2016 10; 44(4):914-22.J Magn Reson Imaging2016-05-13T00:00:0020164D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension.Authorship 151371125309029Kheyfets VO, Kieweg SLJournal of non-Newtonian fluid mechanicsKheyfets VO, Kieweg SL. Gravity-Driven Thin Film Flow of an Ellis Fluid. J Nonnewton Fluid Mech. 2013 Dec 01; 202:88-98.J Nonnewton Fluid Mech2013-12-01T00:00:002013Gravity-Driven Thin Film Flow of an Ellis Fluid.Authorship 155366127684888Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas RJournal of biomechanical engineeringKheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A Zero-Dimensional Model and Protocol for Simulating Patient-Specific Pulmonary Hemodynamics From Limited Clinical Data. J Biomech Eng. 2016 12 01; 138(12).J Biomech Eng2016-12-01T00:00:002016A Zero-Dimensional Model and Protocol for Simulating Patient-Specific Pulmonary Hemodynamics From Limited Clinical Data.5Other Faculty1Professor3Asst Professor2Assoc Professor4InstructorAuthorship 158983427444679Sch?fer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong UEuropean heart journal. Cardiovascular ImagingSch?fer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2017 Apr 01; 18(4):424-431.Eur Heart J Cardiovasc Imaging2017-04-01T00:00:002017Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension.Authorship 159399728193613Sch?fer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong UCirculation. Cardiovascular imagingSch?fer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong U. Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency? Circ Cardiovasc Imaging. 2017 02; 10(2).Circ Cardiovasc Imaging2017-02-01T00:00:002017Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency?Authorship 167897128819545Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas ROxidative medicine and cellular longevityKheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017; 2017:4957147.Oxid Med Cell Longev2017-07-27T00:00:002017Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function.Authorship 170626228986100Sch?fer M, Kheyfets VO, Barker AJ, Stenmark K, Hunter KS, McClatchey PM, Buckner JK, Reece TB, Jazaeri O, Fenster BEJournal of vascular surgerySch?fer M, Kheyfets VO, Barker AJ, Stenmark K, Hunter KS, McClatchey PM, Buckner JK, Reece TB, Jazaeri O, Fenster BE. Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease. J Vasc Surg. 2018 07; 68(1):246-253.J Vasc Surg2017-10-03T00:00:002017Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease.Authorship 171082829043395Sch?fer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson NPediatric cardiologySch?fer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson N. Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI. Pediatr Cardiol. 2018 Feb; 39(2):268-274.Pediatr Cardiol2017-10-17T00:00:002017Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI.Authorship 1736342Authorship 173891329245182Kong F, Kheyfets V, Finol E, Cai XCInternational journal for numerical methods in biomedical engineeringKong F, Kheyfets V, Finol E, Cai XC. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. Int J Numer Method Biomed Eng. 2018 04; 34(4):e2952.Int J Numer Method Biomed Eng2018-02-02T00:00:002018An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery.29263034Sch?fer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KSJournal of the American Heart AssociationSch?fer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KS. Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J Am Heart Assoc. 2017 Dec 20; 6(12).J Am Heart Assoc2017-12-20T00:00:002017Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations.Authorship 177986428460004Sch?fer M, Humphries S, Stenmark KR, Kheyfets VO, Buckner JK, Hunter KS, Fenster BEEuropean heart journal. Cardiovascular ImagingSch?fer M, Humphries S, Stenmark KR, Kheyfets VO, Buckner JK, Hunter KS, Fenster BE. 4D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease. Eur Heart J Cardiovasc Imaging. 2018 04 01; 19(4):415-424.Eur Heart J Cardiovasc Imaging2018-04-01T00:00:0020184D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease.Authorship 181462329786774Bordones AD, Leroux M, Kheyfets VO, Wu YA, Chen CY, Finol EAAnnals of biomedical engineeringBordones AD, Leroux M, Kheyfets VO, Wu YA, Chen CY, Finol EA. Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation. Ann Biomed Eng. 2018 Sep; 46(9):1309-1324.Ann Biomed Eng2018-05-21T00:00:002018Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation.D019028Procedures551540.907004Magnetic Resonance Imaging, CineMichalSchaferMichal Schafer39.74403510000000-104.8360594000000014370Schafer, MichalResearch InstructorAuthorship 184030630003835Dufva MJ, Truong U, Tiwari P, Ivy DD, Shandas R, Kheyfets VOPulmonary circulationDufva MJ, Truong U, Tiwari P, Ivy DD, Shandas R, Kheyfets VO. Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2018 Jul-Sep; 8(3):2045894018791352.Pulm Circ2018-07-13T00:00:002018Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension.MorrisHuangMorris Huang39.74773620000000-104.8392136000000014525Huang, MorrisAsst Professor-ResearchD003198Activities & Behaviors4349450.702261Computer SimulationAuthorship 195302130714069Kheyfets VO, Truong U, Ivy D, Shandas RJournal of biomechanical engineeringKheyfets VO, Truong U, Ivy D, Shandas R. Structural and Biomechanical Adaptations of Right Ventricular Remodeling-In Pulmonary Arterial Hypertension-Reduces Left Ventricular Rotation During Contraction: A Computational Study. J Biomech Eng. 2019 May 01; 141(5).J Biomech Eng2019-05-01T00:00:002019Structural and Biomechanical Adaptations of Right Ventricular Remodeling-In Pulmonary Arterial Hypertension-Reduces Left Ventricular Rotation During Contraction: A Computational Study.D006976Disorders26219000.426501Hypertension, PulmonaryAuthorship 1964461730822118Sch?fer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong UAmerican journal of physiology. Heart and circulatory physiologySch?fer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong U. Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies. Am J Physiol Heart Circ Physiol. 2019 05 01; 316(5):H1091-H1104.Am J Physiol Heart Circ Physiol2019-03-01T00:00:002019Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies.D011651Anatomy17510970.626036Pulmonary ArteryAuthorship 199278230989794Kong F, Kheyfets V, Finol E, Cai XCInternational journal for numerical methods in biomedical engineeringKong F, Kheyfets V, Finol E, Cai XC. Simulation of unsteady blood flows in a patient-specific compliant pulmonary artery with a highly parallel monolithically coupled fluid-structure interaction algorithm. Int J Numer Method Biomed Eng. 2019 07; 35(7):e3208.Int J Numer Method Biomed Eng2019-05-20T00:00:002019Simulation of unsteady blood flows in a patient-specific compliant pulmonary artery with a highly parallel monolithically coupled fluid-structure interaction algorithm.D018497Disorders792320.789031Ventricular Dysfunction, RightAuthorship 200808431109778Breeman KTN, Dufva M, Ploegstra MJ, Kheyfets V, Willems TP, Wigger J, Hunter KS, Ivy DD, Berger RMF, Truong UInternational journal of cardiologyBreeman KTN, Dufva M, Ploegstra MJ, Kheyfets V, Willems TP, Wigger J, Hunter KS, Ivy DD, Berger RMF, Truong U. Right ventricular-vascular coupling ratio in pediatric pulmonary arterial hypertension: A comparison between cardiac magnetic resonance and right heart catheterization measurements. Int J Cardiol. 2019 10 15; 293:211-217.Int J Cardiol2019-05-10T00:00:002019Right ventricular-vascular coupling ratio in pediatric pulmonary arterial hypertension: A comparison between cardiac magnetic resonance and right heart catheterization measurements.CARD CVP LABORATORYCEDC-BioengineeringPUL GENERAL OPERATIONSPULM&SLEEPMEDSOM-MEDSOM-PEDSSOM-SRGCritical CareCT ClinicalCardiologyUniversity of Colorado Denver - Anschutz Medical CampusKurtStenmarkKurt R Stenmark39.74515960000000-104.840628000000001165Stenmark, KurtProfessorEmilyGibsonEmily A Gibson39.74773620000000-104.839213600000001009Gibson, EmilyAssociate ProfessorRobinShandasRobin Shandas39.74403510000000-104.836059400000001367Shandas, RobinDistinguished ProfessorRubinTuderRubin M Tuder39.74515960000000-104.840628000000001369Tuder, RubinProfessorKendallHunterKendall S Hunter39.74403510000000-104.836059400000001402Hunter, KendallAssociate ProfessorDae WonParkDae Won Park39.74773620000000-104.839213600000004067Park, Dae WonAssociate ProfessorRichardWeirRichard F Weir39.74773620000000-104.839213600000003756Weir, RichardAssoc Professor-ResearchJeffreyJacotJeffrey Jacot39.74773620000000-104.839213600000005515Jacot, JeffreyAssociate ProfessorStevenAbmanSteven H Abman39.74403510000000-104.83605940000000518Abman, StevenProfessorDavidIvyDavid D Ivy39.74403510000000-104.83605940000000683Ivy, DavidProfessorAuthorship 2121471131738411Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter ECardiovascular researchBoehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding. Cardiovasc Res. 2020 08 01; 116(10):1700-1709.Cardiovasc Res2020-08-01T00:00:002020Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.Authorship 217785632206308Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SMPulmonary circulationKopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar; 10(1):2045894020912937.Pulm Circ2020-03-13T00:00:002020Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice.Authorship 220066132367677Kheyfets VO, Dufva MJ, Boehm M, Tian X, Qin X, Tabakh JE, Truong U, Ivy D, Spiekerkoetter EPhysiological reportsKheyfets VO, Dufva MJ, Boehm M, Tian X, Qin X, Tabakh JE, Truong U, Ivy D, Spiekerkoetter E. The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload. Physiol Rep. 2020 05; 8(9):e14347.Physiol Rep2020-05-01T00:00:002020The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload.2022-07-31NIHKHEYFETS, VITALY2017-08-01Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertensionK25HL133481Principal Investigator12700 E. 19th Ave.2RBResearch Bridge12700 E. 19th Ave.Aurora80045-2560CO2.461270.0144426185research areas2.962760.039876349coauthor of96.53037.7942960similar to1152selected publicationsAuthorship 224392132712582Kheyfets VO, Lammers SR, Wagner J, Bartels K, Piccoli J, Smith BJRespiratory careKheyfets VO, Lammers SR, Wagner J, Bartels K, Piccoli J, Smith BJ. PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response. Respir Care. 2020 08; 65(8):1094-1103.Respir Care2020-08-01T00:00:002020PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response.Authorship 1006711Authorship 1009342Authorship 1009563123445061Steinman DA, Hoi Y, Fahy P, Morris L, Walsh MT, Aristokleous N, Anayiotos AS, Papaharilaou Y, Arzani A, Shadden SC, Berg P, Janiga G, Bols J, Segers P, Bressloff NW, Cibis M, Gijsen FH, Cito S, Pallar?s J, Browne LD, Costelloe JA, Lynch AG, Degroote J, Vierendeels J, Fu W, Qiao A, Hodis S, Kallmes DF, Kalsi H, Long Q, Kheyfets VO, Finol EA, Kono K, Malek AM, Lauric A, Menon PG, Pekkan K, Esmaily Moghadam M, Marsden AL, Oshima M, Katagiri K, Peiffer V, Mohamied Y, Sherwin SJ, Schaller J, Goubergrits L, Usera G, Mendina M, Valen-Sendstad K, Habets DF, Xiang J, Meng H, Yu Y, Karniadakis GE, Shaffer N, Loth FJournal of biomechanical engineeringSteinman DA, Hoi Y, Fahy P, Morris L, Walsh MT, Aristokleous N, Anayiotos AS, Papaharilaou Y, Arzani A, Shadden SC, Berg P, Janiga G, Bols J, Segers P, Bressloff NW, Cibis M, Gijsen FH, Cito S, Pallar?s J, Browne LD, Costelloe JA, Lynch AG, Degroote J, Vierendeels J, Fu W, Qiao A, Hodis S, Kallmes DF, Kalsi H, Long Q, Kheyfets VO, Finol EA, Kono K, Malek AM, Lauric A, Menon PG, Pekkan K, Esmaily Moghadam M, Marsden AL, Oshima M, Katagiri K, Peiffer V, Mohamied Y, Sherwin SJ, Schaller J, Goubergrits L, Usera G, Mendina M, Valen-Sendstad K, Habets DF, Xiang J, Meng H, Yu Y, Karniadakis GE, Shaffer N, Loth F. Variability of computational fluid dynamics solutions for pressure and flow in a giant aneurysm: the ASME 2012 Summer Bioengineering Conference CFD Challenge. J Biomech Eng. 2013 Feb; 135(2):021016.J Biomech Eng2013-02-01T00:00:002013Variability of computational fluid dynamics solutions for pressure and flow in a giant aneurysm: the ASME 2012 Summer Bioengineering Conference CFD Challenge.23608300Zhang H, Kheyfets VO, Finol EAMedical engineering & physicsZhang H, Kheyfets VO, Finol EA. Robust infrarenal aortic aneurysm lumen centerline detection for rupture status classification. Med Eng Phys. 2013 Sep; 35(9):1358-67.Med Eng Phys2013-04-20T00:00:002013Robust infrarenal aortic aneurysm lumen centerline detection for rupture status classification.23699721Kheyfets VO, Kieweg SLJournal of biomechanical engineeringKheyfets VO, Kieweg SL. Experimental and numerical models of three-dimensional gravity-driven flow of shear-thinning polymer solutions used in vaginal delivery of microbicides. J Biomech Eng. 2013 Jun; 135(6):61009-14.J Biomech Eng2013-06-01T00:00:002013Experimental and numerical models of three-dimensional gravity-driven flow of shear-thinning polymer solutions used in vaginal delivery of microbicides.2025-06-30NIHSTENMARK, KURT R.2020-08-01Complement Mediated Remodeling in Pulmonary Vascular DiseaseP01HL152961Authorship 2379403Authorship 2378772Authorship 2382301031771999Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh IThe European respiratory journalHeerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. Eur Respir J. 2020 03; 55(3).Eur Respir J2020-03-12T00:00:002020A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept.33749613Stroh JN, Bennett TD, Kheyfets V, Albers DJMIR medical informaticsStroh JN, Bennett TD, Kheyfets V, Albers D. Clinical Decision Support for Traumatic Brain Injury: Identifying a Framework for Practical Model-Based Intracranial Pressure Estimation at Multihour Timescales. JMIR Med Inform. 2021 Mar 22; 9(3):e23215.JMIR Med Inform2021-03-22T00:00:002021Clinical Decision Support for Traumatic Brain Injury: Identifying a Framework for Practical Model-Based Intracranial Pressure Estimation at Multihour Timescales.33821682Sch?fer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong UJournal of the American Heart AssociationSch?fer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong U. Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 04 20; 10(8):e020548.J Am Heart Assoc2021-04-06T00:00:002021Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension.Authorship 2399761233938785Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter EAmerican journal of respiratory cell and molecular biologyBoehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Improving Right Ventricular Function by Increasing BMP Signaling with FK506. Am J Respir Cell Mol Biol. 2021 09; 65(3):272-287.Am J Respir Cell Mol Biol2021-09-01T00:00:002021Improving Right Ventricular Function by Increasing BMP Signaling with FK506.Authorship 2415491034078382Dufva MJ, Boehm M, Ichimura K, Truong U, Qin X, Tabakh J, Hunter KS, Ivy D, Spiekerkoetter E, Kheyfets VOJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceDufva MJ, Boehm M, Ichimura K, Truong U, Qin X, Tabakh J, Hunter KS, Ivy D, Spiekerkoetter E, Kheyfets VO. Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2021 06 03; 23(1):66.J Cardiovasc Magn Reson2021-06-03T00:00:002021Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension.Authorship 244171434251418Walter R, Hunter K, Stenmark K, Kheyfets VOJournal of biomechanical engineeringWalter R, Hunter K, Stenmark K, Kheyfets VO. Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study. J Biomech Eng. 2022 02 01; 144(2).J Biomech Eng2022-02-01T00:00:002022Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study.Authorship 250500934583983Dufva MJ, Ivy D, Campbell K, Lam A, Rauff A, Breeman KTN, Douwes JM, Berger RMF, Kheyfets VO, Hunter KOpen heartDufva MJ, Ivy D, Campbell K, Lam A, Rauff A, Breeman KTN, Douwes JM, Berger RMF, Kheyfets VO, Hunter K. Ventricular-vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension. Open Heart. 2021 09; 8(2).Open Heart2021-09-01T00:00:002021Ventricular-vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension.2022-08-31NIHKHEYFETS, VITALY2021-09-15Cause and effect of transient changes in stress, gene expression, and RV fiber orientation during RV remodeling, and its impact on RV function and inter-ventricular coupling in pulmonary hypertensionR56HL152250Principal InvestigatorAuthorship 258585435150211Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello KESC heart failureHeerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure-based estimation of right ventricular ejection fraction. ESC Heart Fail. 2022 04; 9(2):1436-1443.ESC Heart Fail2022-02-12T00:00:002022Pressure-based estimation of right ventricular ejection fraction.Authorship 259039235486078Mickael C, Kheyfets VO, Langou?t-Astri? C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RMAmerican journal of respiratory cell and molecular biologyMickael C, Kheyfets VO, Langou?t-Astri? C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 05; 66(5):580-581.Am J Respir Cell Mol Biol2022-05-01T00:00:002022Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.Authorship 2628921035608266Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KRAmerican journal of physiology. Lung cellular and molecular physiologyCampbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L58-L68.Am J Physiol Lung Cell Mol Physiol2022-05-24T00:00:002022Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia.Authorship 264564435812239McConnell BV, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Sillau SH, Pulver RL, Bettcher BMFrontiers in neuroscienceMcConnell BV, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Sillau SH, Pulver RL, Bettcher BM. The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep. Front Neurosci. 2022; 16:915934.Front Neurosci2022-06-23T00:00:002022The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep.Authorship 2706304Authorship 273044336339935Javadi E, Laudenschlager S, Kheyfets V, Di Maria M, Stone M, Jamali S, Powell AJ, Moghari MHJournal of clinical images and medical case reportsJavadi E, Laudenschlager S, Kheyfets V, Di Maria M, Stone M, Jamali S, Powell AJ, Moghari MH. Predicting Hemodynamic Performance of Fontan Operation for Glenn Physiology using Computational Fluid Dynamics: Ten Patient-specific Cases. J Clin Images Med Case Rep. 2022 Jun; 3(6).J Clin Images Med Case Rep2022-06-29T00:00:002022Predicting Hemodynamic Performance of Fontan Operation for Glenn Physiology using Computational Fluid Dynamics: Ten Patient-specific Cases.36715285Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KRComprehensive PhysiologyGu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 01 30; 13(1):4295-4319.Compr Physiol2023-01-30T00:00:002023Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension.Authorship 277001136776484Kheyfets VO, Sweatt AJ, Gomberg-Maitland M, Ivy DD, Condliffe R, Kiely DG, Lawrie A, Maron BA, Zamanian RT, Stenmark KRERJ open researchKheyfets VO, Sweatt AJ, Gomberg-Maitland M, Ivy DD, Condliffe R, Kiely DG, Lawrie A, Maron BA, Zamanian RT, Stenmark KR. Computational platform for doctor-artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study. ERJ Open Res. 2023 Jan; 9(1).ERJ Open Res2023-02-06T00:00:002023Computational platform for doctor-artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study.Authorship 277420436824720Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BVbioRxiv : the preprint server for biologyPulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping Sleep's Oscillatory Events as a Biomarker of Alzheimer's Disease. bioRxiv. 2023 Feb 16.bioRxiv2023-02-16T00:00:002023Mapping Sleep's Oscillatory Events as a Biomarker of Alzheimer's Disease.36944195Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KRAmerican journal of respiratory cell and molecular biologyHu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 07; 69(1):73-86.Am J Respir Cell Mol Biol2023-07-01T00:00:002023The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.36961489Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KRAmerican journal of physiology. Heart and circulatory physiologyBrown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820.Am J Physiol Heart Circ Physiol2023-03-24T00:00:002023Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model.Authorship 2804088Authorship 28054219Principal InvestigatorIdentify transcriptomic signature driving fiber re-orientation during myocardial remodeling and how it impacts pumping function and inter-ventricular couplingCo-InvestigatorConsultantCo-InvestigatorConsultant2025-09-30DODLEE2022-10-01The pathobiological role of dysregulated pulmonary vascular metabolism in systemic sclerosis-associated pulmonary arterial hypertension.SL2100062027-02-28NIH/NHLBIKHEYFETS, VITALY2023-03-01What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?R01HL1522502023-11-30NIH/NHLBIHEDJAZI2022-12-01Developing a computational platform for in silico surgical intervention for Fontan surgery.25B17162025-05-31NIHSPIEKERKOETTER, EDDA FRAUKE2021-07-25Understanding and targeting molecular as well as structural events governing right ventricular adaptation, failure and recovery in pulmonary hypertension using repurposed drugsR01HL158868Authorship 281840837063750Ichimura K, Santana EJ, Kuznetsova T, Cauwenberghs N, Sabovcik F, Chun L, Francisco NLC, Kheyfets VO, Salerno M, Zamanian RT, Spiekerkoetter E, Haddad FPulmonary circulationIchimura K, Santana EJ, Kuznetsova T, Cauwenberghs N, Sabovcik F, Chun L, Francisco NLC, Kheyfets VO, Salerno M, Zamanian RT, Spiekerkoetter E, Haddad F. Novel left ventricular mechanical index in pulmonary arterial hypertension. Pulm Circ. 2023 Apr; 13(2):e12216.Pulm Circ2023-04-01T00:00:002023Novel left ventricular mechanical index in pulmonary arterial hypertension.37298696Kheyfets VO, Kumar S, Heerdt PM, Ichimura K, Brown RD, Lucero M, Essafri I, Williams S, Stenmark KR, Spiekerkoetter EInternational journal of molecular sciencesKheyfets VO, Kumar S, Heerdt PM, Ichimura K, Brown RD, Lucero M, Essafri I, Williams S, Stenmark KR, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. Int J Mol Sci. 2023 Jun 05; 24(11).Int J Mol Sci2023-06-05T00:00:002023Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload.Authorship 2842841TimLahmTim Lahm28673Lahm, TimAffiliate - NJHtrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 288748437610059Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BVAlzheimer's & dementia : the journal of the Alzheimer's AssociationPulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease. Alzheimers Dement. 2024 Jan; 20(1):301-315.Alzheimers Dement2023-08-23T00:00:002023Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease.true1ProfessorProfessortrue1ProfessorProfessortrue1Affiliate - NJHAffiliate - NJHtrue1Research InstructorResearch Instructor2026-12-31NIHKHEYFETS, VITALY2023-05-01What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?R01HL152250Principal Investigatortrue1Associate ProfessorAssociate Professortrue1Assoc Professor-ResearchAssoc Professor-Researchtrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Asst Professor-ResearchAsst Professor-Researchtrue1Associate ProfessorAssociate Professortrue1Distinguished ProfessorDistinguished ProfessorAuthorship 110072124718322Kheyfets VO, Thornton RC, Kowal M, Finol EAJournal of biomechanical engineeringKheyfets VO, Thornton RC, Kowal M, Finol EA. A protocol for measuring pull-off stress of wound-treatment polymers. J Biomech Eng. 2014 Jul; 136(7).J Biomech Eng2014-07-01T00:00:002014A protocol for measuring pull-off stress of wound-treatment polymers.