In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.
Wang D, Piknova B, Solomon SB, Cortes-Puch I, Kern SJ, Sun J, Kanias T, Gladwin MT, Helms C, Kim-Shapiro DB, Schechter AN, Natanson C. In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion. 2013 Dec; 53(12):3149-63.