RebeccaMcCulloughRebecca LeAnne McCullough39.73010690000000-104.937882000000006605McCullough, RebeccaLeAnne303/724-6415Asst Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:orcidIdORCID idvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonElizabethKovacsElizabeth J Kovacs39.74403280000000-104.8408104000000011212Kovacs, Elizabeth0000-0002-9459=9928Professor27124661Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DRPloS oneShearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152.PLoS One2016-04-28T00:00:002016Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.TimothyWaxweilerTimothy V. Waxweiler39.73010690000000-104.9378820000000011604Waxweiler, TimothyAsst Professor1Professor3Asst Professor2Assoc Professor4Instructor21354120Smathers RL, Galligan JJ, Stewart BJ, Petersen DRChemico-biological interactionsSmathers RL, Galligan JJ, Stewart BJ, Petersen DR. Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. Chem Biol Interact. 2011 Jun 30; 192(1-2):107-12.Chem Biol Interact2011-02-24T00:00:002011Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease.21415306Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N, Petersen DRMolecular pharmacologyShearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N, Petersen DR. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. Mol Pharmacol. 2011 Jun; 79(6):941-52.Mol Pharmacol2011-03-17T00:00:002011Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.21504868Smathers RL, Petersen DRHuman genomicsSmathers RL, Petersen DR. The human fatty acid-binding protein family: evolutionary divergences and functions. Hum Genomics. 2011 Mar; 5(3):170-91.Hum Genomics2011-03-01T00:00:002011The human fatty acid-binding protein family: evolutionary divergences and functions.22502949Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DRChemical research in toxicologyGalligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol. 2012 May 21; 25(5):1012-21.Chem Res Toxicol2012-05-01T00:00:002012Protein carbonylation in a murine model for early alcoholic liver disease.22701647Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DRPloS oneSmathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. PLoS One. 2012; 7(6):e38459.PLoS One2012-06-06T00:00:002012Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.23359610Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DRJournal of lipid researchSmathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. J Lipid Res. 2013 May; 54(5):1335-45.J Lipid Res2013-01-28T00:00:002013Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.21449565Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DRChemical research in toxicologyFritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62.Chem Res Toxicol2011-04-14T00:00:0020114-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.21319786Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DRJournal of proteome researchGalligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47.J Proteome Res2011-03-07T00:00:002011Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.22829816Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DRJournal of toxicologyGalligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. J Toxicol. 2012; 2012:207594.J Toxicol2012-07-05T00:00:002012Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.D008099Anatomy52318270.540389Liver12850 E. Montview Bouldervard2SPPSSkaggs School of Pharmacy12850 E. Montview BouldervardAurora80045-2605COAuthorship 1885801Authorship 1886036Authorship 1886352Authorship 1886812Authorship 1887671Authorship 1888861Authorship 188960329597356McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LEAmerican journal of physiology. Gastrointestinal and liver physiologyMcCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE. Complement Factor D protects mice from ethanol-induced inflammation and liver injury. Am J Physiol Gastrointest Liver Physiol. 2018 07 01; 315(1):G66-G79.Am J Physiol Gastrointest Liver Physiol2018-03-29T00:00:002018Complement Factor D protects mice from ethanol-induced inflammation and liver injury.29142263Saikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LEScientific reportsSaikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LE. Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip. Sci Rep. 2017 Nov 15; 7(1):15671.Sci Rep2017-11-15T00:00:002017Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip.27280845McCullough RL, McMullen MR, Das D, Roychowdhury S, Strainic MG, Medof ME, Nagy LEMolecular immunologyMcCullough RL, McMullen MR, Das D, Roychowdhury S, Strainic MG, Medof ME, Nagy LE. Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice. Mol Immunol. 2016 07; 75:122-32.Mol Immunol2016-06-06T00:00:002016Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice.27302422McCullough RL, Saikia P, Pollard KA, McMullen MR, Nagy LE, Roychowdhury SGene expressionMcCullough RL, Saikia P, Pollard KA, McMullen MR, Nagy LE, Roychowdhury S. Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice. Gene Expr. 2016; 17(1):61-77.Gene Expr2016-06-09T00:00:002016Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice.29374837Kim A, McCullough RL, Poulsen KL, Sanz-Garcia C, Sheehan M, Stavitsky AB, Nagy LEHandbook of experimental pharmacologyKim A, McCullough RL, Poulsen KL, Sanz-Garcia C, Sheehan M, Stavitsky AB, Nagy LE. Hepatic Immune System: Adaptations to Alcohol. Handb Exp Pharmacol. 2018; 248:347-367.Handb Exp Pharmacol2018-01-01T00:00:002018Hepatic Immune System: Adaptations to Alcohol.27301788Roychowdhury S, McCullough RL, Sanz-Garcia C, Saikia P, Alkhouri N, Matloob A, Pollard KA, McMullen MR, Croniger CM, Nagy LEHepatology (Baltimore, Md.)Roychowdhury S, McCullough RL, Sanz-Garcia C, Saikia P, Alkhouri N, Matloob A, Pollard KA, McMullen MR, Croniger CM, Nagy LE. Receptor interacting protein 3 protects mice from high-fat diet-induced liver?injury. Hepatology. 2016 11; 64(5):1518-1533.Hepatology2016-07-17T00:00:002016Receptor interacting protein 3 protects mice from high-fat diet-induced liver?injury.Principal InvestigatorAuthorship 189281Authorship 189282Authorship 189283Authorship 189284Authorship 189285Authorship 189286Authorship 1892876Authorship 1892889Authorship 1892895Authorship 1892905Authorship 189291Authorship 1892922Authorship 189293Authorship 1892947Authorship 1892953Authorship 18929612019-01-31NIHSMATHERS MCCULLOUGH, REBECCA LEANNE2017-02-15Altered Treg differentiation in ALD: a novel role for anaphylatoxins C3a and C5aK99AA02538626922040Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LEMolecular immunologySmathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE. Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol. 2016 Apr; 72:9-18.Mol Immunol2016-02-27T00:00:002016Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice.30294325McCullough RL, McMullen MR, Poulsen KL, Kim A, Medof ME, Nagy LEFrontiers in immunologyMcCullough RL, McMullen MR, Poulsen KL, Kim A, Medof ME, Nagy LE. Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome. Front Immunol. 2018; 9:2133.Front Immunol2018-09-20T00:00:002018Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome.D044087Chemicals & Drugs15300.963162Receptor, Anaphylatoxin C5a23465594Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DRThe Journal of nutritional biochemistryShearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem. 2013 Aug; 24(8):1436-45.J Nutr Biochem2013-03-01T00:00:002013Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.Genetics & MetabolismD022781Anatomy1002060.895867HepatocytesD000431Chemicals & Drugs2025840.702423EthanolD008108Disorders29880.921047Liver Diseases, AlcoholicSOM-RADONC General OperationsSOM-MEDSOM-PathologySOM-PEDSSOM-PSYCHSOM-SRGSOP-AdministrationCON-DEAN AdministrationSUBDEPGastroGI ClinicalInfectious DiseaseTS ClinicalUniversity of Colorado Denver - Anschutz Medical CampusDavidOrlickyDavid J Orlicky39.74545800000000-104.839369100000001404Orlicky, DavidAssociate ProfessorRachelMcMahanRachel H. McMahan39.74515960000000-104.840628000000001637McMahan, RachelAssoc Professor-ResearchCarolHeinischCarol Heinisch39.73010690000000-104.937882000000002185Heinisch, CarolClinical InstructorCharlesDinarelloCharles A Dinarello39.74528180000000-104.8375727000000023Dinarello, CharlesDistinguished ProfessorKristoferFritzKristofer S Fritz39.74688660000000-104.838256700000004273Fritz, KristoferAssociate ProfessorKentHutchisonKent Edward Hutchison40.00869130000000-105.26898330000000698Hutchison, KentProfessorCarlyneCoolCarlyne Cool39.73010690000000-104.93788200000000773Cool, CarlyneProfessor-ClinicalBarbaraMartinBarbara Josephine Martin39.73010690000000-104.937882000000003842Martin, BarbaraAsst Professor AdjunctColinShearnColin Tucker Shearn39.74688660000000-104.838256700000004270Shearn, ColinAsst Professor-Research4.631720.0104564206research areas1.295220.029006925coauthor of43.47695.6189760similar to1138selected publicationsAuthorship 2186801032353591McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJAlcohol (Fayetteville, N.Y.)McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJ. Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol. 2020 09; 87:89-95.Alcohol2020-04-28T00:00:002020Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury.Authorship 221922232557728Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LEHepatology (Baltimore, Md.)Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.Hepatology2020-11-22T00:00:002020Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis.Authorship 2253931232799332Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy SHepatology (Baltimore, Md.)Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. Hepatology. 2021 05; 73(5):1892-1908.Hepatology2021-04-20T00:00:002021Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease.Authorship 2279601632961356Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jir?n Tamburini BACellular and molecular gastroenterology and hepatologyBurchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jir?n Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2021; 11(2):573-595.Cell Mol Gastroenterol Hepatol2020-09-19T00:00:002020Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System.Authorship 228676433020981Walrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJJournal of leukocyte biologyWalrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJ. Age-related changes in intestinal immunity and the microbiome. J Leukoc Biol. 2021 06; 109(6):1045-1061.J Leukoc Biol2020-10-05T00:00:002020Age-related changes in intestinal immunity and the microbiome.Authorship 2539181134923085Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KSAlcohol (Fayetteville, N.Y.)Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KS. Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker. Alcohol. 2022 03; 99:35-48.Alcohol2021-12-17T00:00:002021Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker.Authorship 2632881535659577Khair S, Brenner LA, Koval M, Samuelson D, Cucinello-Regland JA, Anton P, Piano MR, Simon L, Crotty K, Sharieh F, Travers JB, Singh V, Cannon A, Kim A, McCullough RL, Yeligar SM, Wyatt TA, McMahan RH, Choudhry MA, Kovacs EJAlcohol (Fayetteville, N.Y.)Khair S, Brenner LA, Koval M, Samuelson D, Cucinello-Regland JA, Anton P, Piano MR, Simon L, Crotty K, Sharieh F, Travers JB, Singh V, Cannon A, Kim A, McCullough RL, Yeligar SM, Wyatt TA, McMahan RH, Choudhry MA, Kovacs EJ. New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2022 09; 103:1-7.Alcohol2022-06-01T00:00:002022New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Authorship 2763465Authorship 2749025Authorship 2716936Authorship 276532436638633Hvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JNJournal of inorganic biochemistryHvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JN. Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement. J Inorg Biochem. 2023 03; 240:112120.J Inorg Biochem2023-01-04T00:00:002023Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement.36338478Goldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJFrontiers in physiologyGoldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJ. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022; 13:1021038.Front Physiol2022-10-19T00:00:002022Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin.36435276Anton P, Rutt LN, Twardy SM, McCullough RLCellular and molecular gastroenterology and hepatologyAnton P, Rutt LN, Twardy SM, McCullough RL. Fatty Acid Ethyl Ethers: New Modulators of Acute Ethanol-Mediated Hepatotoxicity? Cell Mol Gastroenterol Hepatol. 2023; 15(2):505-506.Cell Mol Gastroenterol Hepatol2022-11-23T00:00:002022Fatty Acid Ethyl Ethers: New Modulators of Acute Ethanol-Mediated Hepatotoxicity?36150611Anton PE, Rutt LN, Capper C, Orlicky DJ, McCullough RLAlcohol (Fayetteville, N.Y.)Anton PE, Rutt LN, Capper C, Orlicky DJ, McCullough RL. Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress. Alcohol. 2023 03; 107:119-135.Alcohol2022-09-20T00:00:002022Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress.Authorship 276849236754053Moghimi SM, McCullough R, Simberg DMolecular therapy : the journal of the American Society of Gene TherapyMoghimi SM, McCullough R, Simberg D. Revisiting nanoparticle transendothelial migration in the liver. Mol Ther. 2023 03 01; 31(3):605-606.Mol Ther2023-02-07T00:00:002023Revisiting nanoparticle transendothelial migration in the liver.Authorship 2821861337061143McMahan RH, Anton P, Coleman LG, Cresci GAM, Crews FT, Crotty KM, Luck ME, Molina PE, Vachharajani V, Weinberg J, Yeligar SM, Choudhry MA, McCullough RL, Kovacs EJAlcohol (Fayetteville, N.Y.)McMahan RH, Anton P, Coleman LG, Cresci GAM, Crews FT, Crotty KM, Luck ME, Molina PE, Vachharajani V, Weinberg J, Yeligar SM, Choudhry MA, McCullough RL, Kovacs EJ. Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting. Alcohol. 2023 08; 110:57-63.Alcohol2023-04-13T00:00:002023Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting.true1Distinguished ProfessorDistinguished Professortrue1Assoc Professor-ResearchAssoc Professor-Researchtrue1Asst Professor-ResearchAsst Professor-Researchtrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Clinical InstructorClinical InstructorAuthorship 2941061537873172Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJbioRxiv : the preprint server for biologyTrujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Lactoylglutathione promotes inflammatory signaling in macrophages. bioRxiv. 2023 Oct 10.bioRxiv2023-10-10T00:00:002023Lactoylglutathione promotes inflammatory signaling in macrophages.Authorship 297445638151165Anton PE, Rutt LN, Kaufman ML, Busquet N, Kovacs EJ, McCullough RLBrain, behavior, and immunityAnton PE, Rutt LN, Kaufman ML, Busquet N, Kovacs EJ, McCullough RL. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain Behav Immun. 2024 Feb; 116:303-316.Brain Behav Immun2023-12-25T00:00:002023Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice.true1Asst Professor AdjunctAsst Professor Adjuncttrue1Asst ProfessorAsst Professortrue1Associate ProfessorAssociate Professortrue1Professor-ClinicalProfessor-Clinicaltrue1Asst ProfessorAsst Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor23872024Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DRFree radical biology & medicineShearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR. Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. Free Radic Biol Med. 2013 Dec; 65:680-692.Free Radic Biol Med2013-07-17T00:00:002013Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.PeterKennealeyPeter Thomas Kennealey39.73010690000000-104.937882000000008633Kennealey, PeterAssociate Professor24818992Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DRPloS oneShearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553.PLoS One2014-05-12T00:00:002014Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.24722988Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DRThe Journal of biological chemistryShearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR. Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. J Biol Chem. 2014 May 30; 289(22):15449-62.J Biol Chem2014-04-10T00:00:002014Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.24924946Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DRFree radical biology & medicineGalligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR. Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function. Free Radic Biol Med. 2014 Aug; 73:411-20.Free Radic Biol Med2014-06-09T00:00:002014Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.