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Connection

Linda Watkins to Pain

This is a "connection" page, showing publications Linda Watkins has written about Pain.

 
Connection Strength
  
 
 
7.563
  
  1. Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends Neurosci. 2016 12; 39(12):862-879.
    View in: PubMed
    Score: 0.336
  2. Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2015 Feb; 44:128-36.
    View in: PubMed
    Score: 0.290
  3. Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nat Rev Immunol. 2014 Apr; 14(4):217-31.
    View in: PubMed
    Score: 0.279
  4. Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May; 30:24-32.
    View in: PubMed
    Score: 0.258
  5. Loram LC, Grace PM, Strand KA, Taylor FR, Ellis A, Berkelhammer D, Bowlin M, Skarda B, Maier SF, Watkins LR. Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy. Brain Behav Immun. 2012 Nov; 26(8):1256-64.
    View in: PubMed
    Score: 0.250
  6. Johnston IN, Maier SF, Rudy JW, Watkins LR. Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat. Behav Brain Res. 2012 Jan 15; 226(2):361-8.
    View in: PubMed
    Score: 0.235
  7. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010 Oct; 11(10):1004-14.
    View in: PubMed
    Score: 0.220
  8. Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, Giffard R, Al-Abed Y, Tracey K, Maier SF, Watkins LR. Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain Behav Immun. 2010 Aug; 24(6):959-67.
    View in: PubMed
    Score: 0.212
  9. Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 2010 Jan 20; 165(2):569-83.
    View in: PubMed
    Score: 0.210
  10. Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 2009 Dec 29; 164(4):1821-32.
    View in: PubMed
    Score: 0.205
  11. Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci. 2009 Jan; 10(1):23-36.
    View in: PubMed
    Score: 0.195
  12. Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun. 2008 Nov; 22(8):1178-89.
    View in: PubMed
    Score: 0.188
  13. Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci. 2008 Jul; 28(1):20-9.
    View in: PubMed
    Score: 0.188
  14. Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev. 2007 Nov; 56(1):148-69.
    View in: PubMed
    Score: 0.176
  15. Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun. 2007 Feb; 21(2):131-46.
    View in: PubMed
    Score: 0.169
  16. Wieseler-Frank J, Jekich BM, Mahoney JH, Bland ST, Maier SF, Watkins LR. A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus. Brain Behav Immun. 2007 Jul; 21(5):711-8.
    View in: PubMed
    Score: 0.166
  17. Banks WA, Watkins LR. Mediation of chronic pain: not by neurons alone. Pain. 2006 Sep; 124(1-2):1-2.
    View in: PubMed
    Score: 0.161
  18. Hodges PW, Fiore NT, Watkins LR, Klyne DM, Coppieters MW, Grace PM. Pain and the immune system. Musculoskelet Sci Pract. 2026 04; 82:103484.
    View in: PubMed
    Score: 0.159
  19. Milligan E, Zapata V, Schoeniger D, Chacur M, Green P, Poole S, Martin D, Maier SF, Watkins LR. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J Neurosci. 2005 Dec; 22(11):2775-82.
    View in: PubMed
    Score: 0.157
  20. Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counter-regulators of opioid analgesia. Trends Neurosci. 2005 Dec; 28(12):661-9.
    View in: PubMed
    Score: 0.156
  21. Wieseler-Frank J, Maier SF, Watkins LR. Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain Behav Immun. 2005 Mar; 19(2):104-11.
    View in: PubMed
    Score: 0.149
  22. Watkins LR, Maier SF. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J Intern Med. 2005 Feb; 257(2):139-55.
    View in: PubMed
    Score: 0.149
  23. Wieseler-Frank J, Maier SF, Watkins LR. Central proinflammatory cytokines and pain enhancement. Neurosignals. 2005; 14(4):166-74.
    View in: PubMed
    Score: 0.148
  24. Milligan ED, Zapata V, Chacur M, Schoeniger D, Biedenkapp J, O'Connor KA, Verge GM, Chapman G, Green P, Foster AC, Naeve GS, Maier SF, Watkins LR. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur J Neurosci. 2004 Nov; 20(9):2294-302.
    View in: PubMed
    Score: 0.146
  25. Spataro LE, Sloane EM, Milligan ED, Wieseler-Frank J, Schoeniger D, Jekich BM, Barrientos RM, Maier SF, Watkins LR. Spinal gap junctions: potential involvement in pain facilitation. J Pain. 2004 Sep; 5(7):392-405.
    View in: PubMed
    Score: 0.144
  26. Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004 Aug; 110(3):517-530.
    View in: PubMed
    Score: 0.144
  27. Wieseler-Frank J, Maier SF, Watkins LR. Glial activation and pathological pain. Neurochem Int. 2004 Jul-Aug; 45(2-3):389-95.
    View in: PubMed
    Score: 0.143
  28. Watkins LR, Maier SF. Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov. 2003 Dec; 2(12):973-85.
    View in: PubMed
    Score: 0.137
  29. Maier SF, Watkins LR. Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain Behav Immun. 2003 Feb; 17 Suppl 1:S125-31.
    View in: PubMed
    Score: 0.129
  30. Watkins LR, Maier SF. Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002 Oct; 82(4):981-1011.
    View in: PubMed
    Score: 0.126
  31. Watkins LR, Milligan ED, Maier SF. Spinal cord glia: new players in pain. Pain. 2001 Sep; 93(3):201-205.
    View in: PubMed
    Score: 0.117
  32. Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci. 2001 Aug; 24(8):450-5.
    View in: PubMed
    Score: 0.117
  33. Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR. Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci. 2001 Apr 15; 21(8):2808-19.
    View in: PubMed
    Score: 0.114
  34. Kwilasz AJ, Green Fulgham SM, Duran-Malle JC, Schrama AEW, Mitten EH, Todd LS, Patel HP, Larson TA, Clements MA, Harris KM, Litwiler ST, Harvey LO, Maier SF, Chavez RA, Rice KC, Van Dam AM, Watkins LR. Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain. Brain Behav Immun. 2021 03; 93:80-95.
    View in: PubMed
    Score: 0.112
  35. Watkins LR, Chavez RA, Landry R, Fry M, Green-Fulgham SM, Coulson JD, Collins SD, Glover DK, Rieger J, Forsayeth JR. Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments. Brain Behav Immun. 2020 11; 90:155-166.
    View in: PubMed
    Score: 0.109
  36. Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol. 2000; 51:29-57.
    View in: PubMed
    Score: 0.104
  37. Watkins LR, Maier SF. Implications of immune-to-brain communication for sickness and pain. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7710-3.
    View in: PubMed
    Score: 0.101
  38. Watkins LR, Maier SF, Goehler LE. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 1995 Dec; 63(3):289-302.
    View in: PubMed
    Score: 0.079
  39. Sutton LC, Fleshner M, Mazzeo R, Maier SF, Watkins LR. A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release. Brain Res. 1994 Nov 07; 663(1):19-29.
    View in: PubMed
    Score: 0.073
  40. Grace PM, Strand KA, Maier SF, Watkins LR. Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. J Pain. 2014 Feb; 15(2):121-8.
    View in: PubMed
    Score: 0.068
  41. Douglass DK, Carstens E, Watkins LR. Spatial summation in human thermal pain perception: comparison within and between dermatomes. Pain. 1992 Aug; 50(2):197-202.
    View in: PubMed
    Score: 0.062
  42. Watkins LR, Wiertelak EP, Maier SF. Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels. Brain Res. 1992 Jun 05; 582(1):10-21.
    View in: PubMed
    Score: 0.062
  43. Watkins LR, Wiertelak EP, Maier SF. Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels. Brain Res. 1992 Jun 05; 582(1):1-9.
    View in: PubMed
    Score: 0.062
  44. Bastos LF, de Oliveira AC, Watkins LR, Moraes MF, Coelho MM. Tetracyclines and pain. Naunyn Schmiedebergs Arch Pharmacol. 2012 Mar; 385(3):225-41.
    View in: PubMed
    Score: 0.060
  45. Wieseler J, Sprunger D, Ellis A, Maier SF, Watkins LR. Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing. Methods Mol Biol. 2012; 851:99-107.
    View in: PubMed
    Score: 0.060
  46. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60.
    View in: PubMed
    Score: 0.059
  47. Campbell IG, Carstens E, Watkins LR. Comparison of human pain sensation and flexion withdrawal evoked by noxious radiant heat. Pain. 1991 Jun; 45(3):259-268.
    View in: PubMed
    Score: 0.058
  48. Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ. PEGylation of interleukin-10 for the mitigation of enhanced pain states. J Biomed Mater Res A. 2010 Jun 01; 93(3):1169-79.
    View in: PubMed
    Score: 0.054
  49. Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. J Neurosci. 2009 Nov 04; 29(44):14015-25.
    View in: PubMed
    Score: 0.052
  50. Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci. 2009 Nov; 30(11):581-91.
    View in: PubMed
    Score: 0.051
  51. Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun. 2008 Nov; 22(8):1248-56.
    View in: PubMed
    Score: 0.047
  52. Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal. 2007 Nov 02; 7:98-111.
    View in: PubMed
    Score: 0.045
  53. Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun. 2007 Jul; 21(5):660-7.
    View in: PubMed
    Score: 0.042
  54. Ledeboer A, Gamanos M, Lai W, Martin D, Maier SF, Watkins LR, Quan N. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci. 2005 Oct; 22(8):1977-86.
    View in: PubMed
    Score: 0.039
  55. Milligan ED, Langer SJ, Sloane EM, He L, Wieseler-Frank J, O'Connor K, Martin D, Forsayeth JR, Maier SF, Johnson K, Chavez RA, Leinwand LA, Watkins LR. Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci. 2005 Apr; 21(8):2136-48.
    View in: PubMed
    Score: 0.038
  56. Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci. 2004 Sep; 20(5):1150-60.
    View in: PubMed
    Score: 0.036
  57. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004 Aug 18; 24(33):7353-65.
    View in: PubMed
    Score: 0.036
  58. Watkins LR, Wiertelak EP, McGorry M, Martinez J, Schwartz B, Sisk D, Maier SF. Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behav Neurosci. 1998 Apr; 112(2):360-78.
    View in: PubMed
    Score: 0.023
  59. Wiertelak EP, Maier SF, Watkins LR. Cholecystokinin antianalgesia: safety cues abolish morphine analgesia. Science. 1992 May 08; 256(5058):830-3.
    View in: PubMed
    Score: 0.015
  60. Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. J Neurochem. 2010 Jul; 114(1):13-27.
    View in: PubMed
    Score: 0.013
  61. Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, Watkins LR, Leinwand L, Milligan E. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Ther. 2009 Oct; 16(10):1210-22.
    View in: PubMed
    Score: 0.013
  62. Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun. 2009 Feb; 23(2):240-50.
    View in: PubMed
    Score: 0.012
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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