 Connection
John Kappler to Thymus Gland
This is a "connection" page, showing publications John Kappler has written about Thymus Gland.
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Connection Strength |
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2.709 |
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Marrack P, Kappler JW. Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med. 2012 Sep 01; 2(9):a007765.
Score: 0.356
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Smith JA, Yuen BTK, Purtha W, Balolong JM, Phipps JD, Crawford F, Bluestone JA, Kappler JW, Anderson MS. Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proc Natl Acad Sci U S A. 2024 May 14; 121(20):e2320268121.
Score: 0.200
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Ramos SA, Morton JJ, Yadav P, Reed B, Alizadeh SI, Shilleh AH, Perrenoud L, Jaggers J, Kappler J, Jimeno A, Russ HA. Generation of functional human thymic cells from induced pluripotent stem cells. J Allergy Clin Immunol. 2022 02; 149(2):767-781.e6.
Score: 0.165
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Marrack P, Kappler J. Positive selection of thymocytes bearing alpha beta T cell receptors. Curr Opin Immunol. 1997 Apr; 9(2):250-5.
Score: 0.122
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Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW. Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5608-17.
Score: 0.117
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Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16729-34.
Score: 0.083
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Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. J Immunol. 2010 May 01; 184(9):4592-5.
Score: 0.076
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Finkel TH, Cambier JC, Kubo RT, Born WK, Marrack P, Kappler JW. The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell. 1989 Sep 22; 58(6):1047-54.
Score: 0.072
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Blackman MA, Marrack P, Kappler J. Influence of the major histocompatibility complex on positive thymic selection of V beta 17a+ T cells. Science. 1989 Apr 14; 244(4901):214-7.
Score: 0.070
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Marrack P, McCormack J, Kappler J. Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium. Nature. 1989 Apr 06; 338(6215):503-5.
Score: 0.070
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Scott-Browne JP, White J, Kappler JW, Gapin L, Marrack P. Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature. 2009 Apr 23; 458(7241):1043-6.
Score: 0.070
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Marrack P, Blackman M, Burgert HG, McCormack JM, Cambier J, Finkel TH, Kappler J. T-cell repertoire and thymus. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:105-10.
Score: 0.069
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Marrack P, Lo D, Brinster R, Palmiter R, Burkly L, Flavell RH, Kappler J. The effect of thymus environment on T cell development and tolerance. Cell. 1988 May 20; 53(4):627-34.
Score: 0.066
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Marrack P, Kushnir E, Born W, McDuffie M, Kappler J. The development of helper T cell precursors in mouse thymus. J Immunol. 1988 Apr 15; 140(8):2508-14.
Score: 0.066
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Huseby ES, Kappler JW, Marrack P. Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains. Mol Immunol. 2008 Feb; 45(3):599-606.
Score: 0.065
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McDuffie M, Roehm N, Born W, Marrack P, Kappler JW. T cell receptor/MHC interactions in the thymus and the shaping of the T cell repertoire. Transplant Proc. 1987 Dec; 19(6 Suppl 7):111-6.
Score: 0.064
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Hannum C, Marrack P, Kubo R, Kappler J. Thymocytes with the predicted properties of pre-T cells. J Exp Med. 1987 Oct 01; 166(4):874-89.
Score: 0.063
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Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell. 1987 Apr 24; 49(2):273-80.
Score: 0.061
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Born W, Rathbun G, Tucker P, Marrack P, Kappler J. Synchronized rearrangement of T-cell gamma and beta chain genes in fetal thymocyte development. Science. 1986 Oct 24; 234(4775):479-82.
Score: 0.059
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Marrack P, Born W, Roehm N, Farr A, Kappler J. T cell receptors in the thymus. Biochem Soc Symp. 1986; 51:197-204.
Score: 0.056
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Farr AG, Anderson SK, Marrack P, Kappler J. Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ. Cell. 1985 Dec; 43(2 Pt 1):543-50.
Score: 0.056
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Huseby ES, White J, Crawford F, Vass T, Becker D, Pinilla C, Marrack P, Kappler JW. How the T cell repertoire becomes peptide and MHC specific. Cell. 2005 Jul 29; 122(2):247-60.
Score: 0.054
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Brown AJ, White J, Shaw L, Gross J, Slabodkin A, Kushner E, Greiff V, Matsuda J, Gapin L, Scott-Browne J, Kappler J, Marrack P. MHC heterozygosity limits T cell receptor variability in CD4 T cells. Sci Immunol. 2024 07 12; 9(97):eado5295.
Score: 0.051
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Bender J, Mitchell T, Kappler J, Marrack P. CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J Exp Med. 1999 Aug 02; 190(3):367-74.
Score: 0.036
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Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 04 05; 4(34).
Score: 0.035
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Liu CP, Kappler JW, Marrack P. Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage. J Exp Med. 1996 Nov 01; 184(5):1619-30.
Score: 0.030
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Kappler JW, Hunter PC, Jacobs D, Lord E. Functional heterogeneity among the T-derived lymphocytes of the mouse. I. Analysis by adult thymectomy. J Immunol. 1974 Jul; 113(1):27-38.
Score: 0.025
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Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D. Molecules in medicine mini review: the aß T cell receptor. J Mol Med (Berl). 2014 Jul; 92(7):735-41.
Score: 0.025
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Hugo P, Kappler JW, Godfrey DI, Marrack PC. Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion. J Immunol. 1994 Feb 01; 152(3):1022-31.
Score: 0.025
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Marrack P, Ignatowicz L, Kappler JW, Boymel J, Freed JH. Comparison of peptides bound to spleen and thymus class II. J Exp Med. 1993 Dec 01; 178(6):2173-83.
Score: 0.024
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Hugo P, Kappler JW, Marrack PC. Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? Immunol Rev. 1993 Oct; 135:133-55.
Score: 0.024
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Hugo P, Kappler JW, Godfrey DI, Marrack PC. A cell line that can induce thymocyte positive selection. Nature. 1992 Dec 17; 360(6405):679-82.
Score: 0.023
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Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P. T cells and their eons-old obsession with MHC. Immunol Rev. 2012 Nov; 250(1):49-60.
Score: 0.022
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Finkel TH, Kappler JW, Marrack PC. Immature thymocytes are protected from deletion early in ontogeny. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3372-4.
Score: 0.022
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Hoffmann M, Kappler JW. The antigen specificity of thymus-derived helper cells. J Immunol. 1972 Jan; 108(1):261-3.
Score: 0.021
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McCormack JE, Wade T, Morales H, Kappler J, Marrack P. Analysis of class II MHC structure in thymic nurse cells. Cell Immunol. 1991 Dec; 138(2):413-22.
Score: 0.021
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Scott-Browne JP, Crawford F, Young MH, Kappler JW, Marrack P, Gapin L. Evolutionarily conserved features contribute to aß T cell receptor specificity. Immunity. 2011 Oct 28; 35(4):526-35.
Score: 0.021
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McCormack JE, Kappler J, Marrack P, Westcott JY. Production of prostaglandin E2 and prostacyclin by thymic nurse cells in culture. J Immunol. 1991 Jan 01; 146(1):239-43.
Score: 0.020
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Marrack P, Blackman M, Kushnir E, Kappler J. The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J Exp Med. 1990 Feb 01; 171(2):455-64.
Score: 0.019
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McDuffie M, Roehm N, Kappler JW, Marrack P. Involvement of major histocompatibility complex products in tolerance induction in the thymus. J Immunol. 1988 Sep 15; 141(6):1840-7.
Score: 0.017
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Born W, White J, Kappler J, Marrack P. Rearrangement of IgH genes in normal thymocyte development. J Immunol. 1988 May 01; 140(9):3228-32.
Score: 0.016
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Marrack P, Kappler J. The T cell receptor. Science. 1987 Nov 20; 238(4830):1073-9.
Score: 0.016
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Jorgensen TN, McKee A, Wang M, Kushnir E, White J, Refaeli Y, Kappler JW, Marrack P. Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol. 2007 Sep 15; 179(6):3417-24.
Score: 0.016
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Born W, McDuffie M, Roehm N, Kushnir E, White J, Thorpe D, Stefano J, Kappler J, Marrack P. Expression and role of the T cell receptor in early thymocyte differentiation in vitro. J Immunol. 1987 Feb 15; 138(4):999-1008.
Score: 0.015
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Marrack P, McDuffie M, Born W, Blackman M, Hannum C, Kappler J. The T cell receptor: its repertoire and role in thymocyte development. Adv Exp Med Biol. 1987; 213:1-12.
Score: 0.015
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Marrack P, Kappler J. The antigen-specific, major histocompatibility complex-restricted receptor on T cells. Adv Immunol. 1986; 38:1-30.
Score: 0.014
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Roehm N, Herron L, Cambier J, DiGuisto D, Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell. 1984 Sep; 38(2):577-84.
Score: 0.013
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Myrick C, DiGuisto R, DeWolfe J, Bowen E, Kappler J, Marrack P, Wakeland EK. Linkage analysis of variations in CD4:CD8 T cell subsets between C57BL/6 and DBA/2. Genes Immun. 2002 May; 3(3):144-50.
Score: 0.011
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Liu CP, Lin WJ, Huang M, Kappler JW, Marrack P. Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):616-21.
Score: 0.008
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Kappler JW, Marrack PC. Functional heterogeneity among the T-derived lymphocytes of the mouse. III. Helper and suppressor T-cells activated by concanavalin A. Cell Immunol. 1975 Jul; 18(1):9-20.
Score: 0.007
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Ignatowicz L, Kappler J, Marrack P. The effects of chronic infection with a superantigen-producing virus. J Exp Med. 1992 Apr 01; 175(4):917-23.
Score: 0.005
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Kappler JW, Hoffmann M, Dutton RW. Regulation of the immune response. I. Differential effect of passively administered antibody on the thymus-derived and bone marrow-derived lymphocytes. J Exp Med. 1971 Sep 01; 134(3 Pt 1):577-87.
Score: 0.005
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Blackman M, Kappler J, Marrack P. The role of the T cell receptor in positive and negative selection of developing T cells. Science. 1990 Jun 15; 248(4961):1335-41.
Score: 0.005
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Blackman MA, Burgert HG, Gerhard-Burgert H, Woodland DL, Palmer E, Kappler JW, Marrack P. A role for clonal inactivation in T cell tolerance to Mls-1a. Nature. 1990 Jun 07; 345(6275):540-2.
Score: 0.005
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Fenton RG, Marrack P, Kappler JW, Kanagawa O, Seidman JG. Isotypic exclusion of gamma delta T cell receptors in transgenic mice bearing a rearranged beta-chain gene. Science. 1988 Aug 26; 241(4869):1089-92.
Score: 0.004
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van Ewijk W, Ron Y, Monaco J, Kappler J, Marrack P, Le Meur M, Gerlinger P, Durand B, Benoist C, Mathis D. Compartmentalization of MHC class II gene expression in transgenic mice. Cell. 1988 May 06; 53(3):357-70.
Score: 0.004
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Blackman MA, Kappler JW, Marrack P. T-cell specificity and repertoire. Immunol Rev. 1988 Jan; 101:5-19.
Score: 0.004
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Finkel TH, McDuffie M, Kappler JW, Marrack P, Cambier JC. Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature. 1987 Nov 12-18; 330(6144):179-81.
Score: 0.004
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Hannum C, Freed JH, Tarr G, Kappler J, Marrack P. Biochemistry and distribution of the T cell receptor. Immunol Rev. 1984 Oct; 81:161-76.
Score: 0.003
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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