 Connection
Co-Authors
This is a "connection" page, showing publications co-authored by Douglas Seals and Zachary Clayton.
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Connection Strength |
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8.584 |
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Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087.
Score: 0.876
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Clayton ZS, Gioscia-Ryan RA, Justice JN, Lubieniecki KL, Hutton DA, Rossman MJ, Zigler MC, Seals DR. Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation. Exp Gerontol. 2022 01; 157:111632.
Score: 0.777
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Clayton ZS, Hutton DA, Mahoney SA, Seals DR. Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging. Aging Cancer. 2021 Jun; 2(1-2):45-69.
Score: 0.755
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Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196.
Score: 0.753
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Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590.
Score: 0.741
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Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488.
Score: 0.716
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Murray KO, Mahoney SA, Ludwig KR, Miyamoto-Ditmon JH, VanDongen NS, Banskota N, Herman AB, Seals DR, Mankowski RT, Rossman MJ, Clayton ZS. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. Aging Cell. 2025 May 28; e70114.
Score: 0.248
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Mahoney SA, Darrah MA, Venkatasubramanian R, Ciotlos S, Rossman MJ, Campisi J, Seals DR, Melov S, Clayton ZS. Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice. Aging Cell. 2025 May 22; e70118.
Score: 0.247
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Venkatasubramanian R, Darrah MA, Mahoney SA, Hutton DA, Maurer GS, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Brunt VE, Singh P, Galligan JJ, Trujillo MN, Kapahi P, Melov S, Campisi J, Rossman MJ, Seals DR, Clayton ZS. Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. bioRxiv. 2025 May 16.
Score: 0.247
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Singh P, Venkatasubramanian R, Mahoney SA, Darrah MA, Ludwig KR, Zhang A, Kaneshiro K, Najera LE, Wimer L, Shanmugam MM, Morazan E, Trujillo M, Galligan J, Sarpong R, Seals DR, Kapahi P, Clayton ZS. Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence. bioRxiv. 2025 Jan 06.
Score: 0.241
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Darrah MA, Longtine AG, Greenberg NT, Mahoney SA, Venkatasubramanian R, VanDongen NS, Reisz JA, D'Alessandro A, Seals DR, de Quiros Miranda YB, Clayton ZS. The influence of a human macronutrient-matched diet on phenotypes in old mice. Geroscience. 2025 Apr; 47(2):2293-2308.
Score: 0.239
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Bernaldo de Quir?s Y, Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Saavedra P, Bossart G, Brunt VE, Clayton ZS, Fern?ndez A, Seals DR. The bottlenose dolphin (Tursiops truncatus): a novel model for studying healthy arterial aging. Am J Physiol Heart Circ Physiol. 2024 Sep 01; 327(3):H660-H665.
Score: 0.234
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Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Rossman MJ, Widlansky ME, Brunt VE, Bernaldo de Quir?s Y, Seals DR, Clayton ZS. Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach. Am J Physiol Heart Circ Physiol. 2024 05 01; 326(5):H1279-H1290.
Score: 0.228
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Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 06; 46(3):3311-3324.
Score: 0.226
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Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 03; 23(3):e14060.
Score: 0.224
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Moreau KL, Clayton ZS, DuBose LE, Rosenberry R, Seals DR. Effects of regular exercise on vascular function with aging: Does sex matter? Am J Physiol Heart Circ Physiol. 2024 01 01; 326(1):H123-H137.
Score: 0.222
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Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H893-H904.
Score: 0.214
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Murray KO, Mahoney SA, Venkatasubramanian R, Seals DR, Clayton ZS. Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions. Exp Gerontol. 2023 03; 173:112105.
Score: 0.211
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Clayton ZS, Craighead DH, Darvish S, Coppock M, Ludwig KR, Brunt VE, Seals DR, Rossman MJ. Promoting healthy cardiovascular aging: emerging topics. J Cardiovasc Aging. 2022; 2.
Score: 0.204
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Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511.
Score: 0.187
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Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice. J Physiol. 2021 02; 599(3):911-925.
Score: 0.180
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Rossman MJ, Gioscia-Ryan RA, Clayton ZS, Murphy MP, Seals DR. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clin Sci (Lond). 2020 06 26; 134(12):1491-1519.
Score: 0.176
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Gioscia-Ryan RA, Clayton ZS, Fleenor BS, Eng JS, Johnson LC, Rossman MJ, Zigler MC, Evans TD, Seals DR. Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening. Geroscience. 2021 02; 43(1):423-432.
Score: 0.176
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Longtine AG, Greenberg NT, Gonzalez A, Lindquist A, VanDongen NS, Mahoney SA, Rahman G, Clayton ZS, Ziemba BP, Ludwig KR, Widlansky ME, Knight R, Seals DR, Brunt VE. Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in Mice. Aging Biol. 2024; 2.
Score: 0.059
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Cavalier AN, Clayton ZS, Wahl D, Hutton DA, McEntee CM, Seals DR, LaRocca TJ. Protective effects of apigenin on the brain transcriptome with aging. Mech Ageing Dev. 2024 Feb; 217:111889.
Score: 0.056
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Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651.
Score: 0.052
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Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848.
Score: 0.049
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Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451.
Score: 0.047
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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